MiR-425 expression profiling in acute myeloid leukemia might guide the treatment choice between allogeneic transplantation and chemotherapy

Yang, Chong‐Ren; Shao, Tingting; Zhang, Huihui; Zhang, Ninghan; Shi, Xiaoying; Liu, Xuejiao; Yao, Yao; Xu, Linyan; Zhu, Sipin; Cao, Jiang; Cheng, Hai; Zhang, Yan; Li, Zhenyu; Niu, Mingshan; Xu, Kailin

doi:10.1186/s12967-018-1647-8

Cited by 17 publications

(14 citation statements)

References 34 publications

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“…Clear evidence suggests that miRNAs play a role in many aspects of AML development, including maintenance of hematopoietic stem cells, growth, proliferation, differentiation, and apoptosis . Moreover, changes in the expression of different types of microRNA have been correlated with prognosis in cases of AML . Gaining the ability to reverse these changes may have therapeutic implications and improve the outcome for these patients…”

Section: Discussionsupporting

confidence: 90%

“…16 Moreover, changes in the expression of different types of microRNA have been correlated with prognosis in cases of AML. 26 Gaining the ability to reverse these changes may have therapeutic implications and improve the outcome for these patients. 15 Among the different types of miRNAs, miR-204 has been the subject of numerous studies in solid cancers.…”

Section: Discussionmentioning

confidence: 99%

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Low expression of miR‐204 is associated with expression of CD34 and poor performance status in denovo AML

Abdelhafiz

El-Sayed

Saber

et al. 2020

Int J Lab Hematology

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AML is the most common type of acute leukemia in adults, accounting for approximately 80% of adult cases of acute leukemia. 1 AML is generally recognized as disease of late age, with first-time diagnoses of AML made at 68 years of age on average. 2 Still, children account for 6% to 7% of cases of AML and have a biology that is quite different from that of adult patients. 3The disease arises from bone marrow stem cells which proliferate uncontrollably with impaired differentiation capacity, leading Abstract Introduction: Acute myeloid leukemia (AML) is the most common acute leukemia in adults. There is growing evidence that microRNAs (miRNAs) provide prognostic information in AML. MiR-204 has a tumor suppressor function, and several studies have proven its role in solid cancers. The aim of this work is to evaluate the level of expression of miR-204 in adults newly diagnosed with AML with normal karyotype and to correlate its level of expression with disease outcome and different prognostic factors. Patients and methods: The study included 87 adult patients newly diagnosed with AML. Detection of miR-204 was done using RT-PCR in patients and seven agematched controls. Results: Acute myeloid leukemia patients showed significantly lower miR-204 expression, compared to control group (P = .029). Low miR-204 expression was significantly associated with positive CD34 (P = .017), with poor performance status (PS) (P = .009), and with the presence of diabetes mellitus (DM) (P = .014). Low expression of miR-204 was also significantly associated with shorter overall survival (OS) (P = .020) and disease-free survival (DFS) (P = .013). Low miR-204 expression was identified as an independent prognostic factor for prediction of shorter OS (P = .034) and DFS (P = .027) in AML. Conclusion: To the best of our knowledge; this is the first time to prove the correlation between miR-204 expression and CD34 expression. Further study of this correlation is needed to confirm the role of miR-204 in CD34-positive cells, including leukemic stem cells. This correlation may have therapeutic implications. MiR-204 can be used as a biomarker for PS in AML patients. K E Y W O R D S acute myeloid leukemia, CD34, leukemic stem cells, miR-204, performance status S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Abdelhafiz AS, Elsayed GM, Saber MM, Gameel A, Hamdy N. Low expression of miR-204 is associated with expression of CD34 and poor performance status in denovo AML. Int J Lab Hematol. 2020;42:263-269.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Low expression of miR‐204 is associated with expression of CD34 and poor performance status in denovo AML

Abdelhafiz

El-Sayed

Saber

et al. 2020

Int J Lab Hematology

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“…The encoded proteins fulfil a wide range of functions with signaling (7 genes), transcription (8 genes) and metabolism (10 genes) being the most prominent (Supplementary Table S9). Five of these genes have been studied in AML (see [16,18,19,20,21,22]).…”

Section: Resultsmentioning

confidence: 99%

The Capacity of Long-Term In Vitro Proliferation of Acute Myeloid Leukemia Cells Supported Only by Exogenous Cytokines Is Associated with a Patient Subset with Adverse Outcome

Brenner

Aasebø

Hernandez-Valladares

et al. 2019

Cancers

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Acute myeloid leukemia (AML) is an aggressive malignancy, which is highly heterogeneous with regard to chemosensitivity and biological features. The AML cell population is organized in a hierarchy that is reflected in the in vitro growth characteristics, with only a minority of cells being able to proliferate for more than two weeks. In this study, we investigated the ability of AML stem cells to survive and proliferate in suspension cultures in the presence of exogenous mediators but without supporting non-leukemic cells. We saw that a high number of maintained stem cells (i.e., a large number of clonogenic cells after five weeks of culture) was associated with decreased overall survival for patients receiving intensive chemotherapy; this prognostic impact was also detected in the multivariate/adjusted analysis. Furthermore, the patients with many clonogenic cells presented more frequently with mutations in transcription-related genes, and also showed a higher abundance of proteins involved in transcription at the time of diagnosis. In conclusion, the growth characteristics of the long-term proliferating leukemic stem cells seem to have an independent prognostic impact in human AML, and these characteristics appear to be reflected by the mutational landscape and the proteome of the patients at the time of diagnosis.

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“…High miR-425 level was associated with significantly longer OS and event-free survival (EFS) in non-transplant patients, but this association was not observed in post allo-HSCT patients. Instead, patients with downregulated miR-425 did better if they had allo-HSCT, suggesting that low miR-425 level might be an indication for transplant [79]. Overexpression of miR-99a predicted adverse prognosis in AML patients irrespective of transplant status, necessitating the investigation of novel alternative treatment in miR-99a overexpressors [80].…”

Section: Micrornas As Biomarkers For Prognosis In Acute Myeloid Leukemiamentioning

confidence: 99%

Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia

et al. 2019

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Acute myeloid leukemia (AML) is a malignant tumor of the immature myeloid hematopoietic cells in the bone marrow (BM). It is a highly heterogeneous disease, with rising morbidity and mortality in older patients. Although researches over the past decades have improved our understanding of AML, its pathogenesis has not yet been fully elucidated. Long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) are three noncoding RNA (ncRNA) molecules that regulate DNA transcription and translation. With the development of RNA-Seq technology, more and more ncRNAs that are closely related to AML leukemogenesis have been discovered. Numerous studies have found that these ncRNAs play an important role in leukemia cell proliferation, differentiation, and apoptosis. Some may potentially be used as prognostic biomarkers. In this systematic review, we briefly described the characteristics and molecular functions of three groups of ncRNAs, including lncRNAs, miRNAs, and circRNAs, and discussed their relationships with AML in detail.

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MiR-425 expression profiling in acute myeloid leukemia might guide the treatment choice between allogeneic transplantation and chemotherapy

Cited by 17 publications

References 34 publications

Low expression of miR‐204 is associated with expression of CD34 and poor performance status in denovo AML

Low expression of miR‐204 is associated with expression of CD34 and poor performance status in denovo AML

The Capacity of Long-Term In Vitro Proliferation of Acute Myeloid Leukemia Cells Supported Only by Exogenous Cytokines Is Associated with a Patient Subset with Adverse Outcome

Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia

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