miR-375 Inhibits Autophagy and Reduces Viability of Hepatocellular Carcinoma Cells Under Hypoxic Conditions

MicroRNA

“…In vivo mouse xenograft studies demonstrated that miR-375 expression reduced tumor growth compared with controls. 35 Similar results were found looking at hypoxia in cardiomyocytes. Jian et al found that miR-204 is downregulated by hypoxia-reoxygenation treatment, but when overexpressed, reduced the conversion of LC3I to LC3II.…”

“…21 miR-375 has been reported to inhibit autophagy through its target, ATG7, in hepatocellular carcinoma (HCC) cells. 22 miR-376b expression targets ATG4C and beclin-1, which, in turn, downregulate autophagy induced by nutrition starvation and rapamycin in breast cancer cells. 23 On the other hand, ectopic expression of miR-7 in human lung cancer and esophageal cancer cell lines enhances autophagy by suppressing epidermal growth factor receptor (EGFR) expression.…”

microRNA-17 regulates the expression of ATG7 and modulates the autophagy process, improving the sensitivity to temozolomide and low-dose ionizing radiation treatments in human glioblastoma cells

“…To date, an increasing number of miRNAs are being discovered as key regulators of many different cellular processes, in particular those related to autophagy death in cells of different tumor, like melanoma, 37 hepatocellular carcinoma, 38 myelogenous leukemia, 39 colon, 40 cervical, 41 and breast cancer; 42 however, to date, only few reports identified miRNA sequences (i.e., miR-30a, miR-21, and miR10b) directly involved in the regulation of the autophagic process in glioma cells. [43][44][45] Among oncogenic miRNAs, one of the best-characterized is miR-17-92, a polycistronic miRNA cluster, designated as OncomiR-1.…”

HepatomiRNoma: The proposal of a new network of targets for diagnosis, prognosis and therapy in hepatocellular carcinoma

“…miR-375 inhibits autophagy through the regulation of ATG7, a gene responsible for auto-phagocytosis (Chang et al, 2012). Liu et al (2010) showed that the expression of this miRNA is reduced in tissue of patients with hepatocellular carcinoma.…”