MiR-375 delivered by lipid-coated doxorubicin-calcium carbonate nanoparticles overcomes chemoresistance in hepatocellular carcinoma

Zhao, Pengxuan; Wu, Shifan; Cheng, Yao; You, Jia; Yan, Chen; Li, Minsi; He, Chuanchuan; Zhang, Xiaojuan; Tan, Yang; Lu, Yao; Lee, Robert J.; He, Xingxing; Xiang, Guangya

doi:10.1016/j.nano.2017.05.010

Cited by 46 publications

(35 citation statements)

References 30 publications

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“…70 The FDA has approved the use of CaCO 3 (without specifying its polymorphism) as a food additive ( §582.1191), a dietary supplement ( §582.5191), a direct food substance ( §184.1191), and a colour additive for food ( §73. 70 to macromolecules (proteins, 77,81,82 growth factors, 83 genes 84,85 ) and inorganic nanoparticles (Ag, 86 ). Importantly, multicomponent encapsulation into VCC is also possible and has been reported (e.g.…”

Section: Caco 3 and Its Polymorphsmentioning

confidence: 99%

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Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

et al. 2020

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Section: Caco 3 and Its Polymorphsmentioning

confidence: 99%

“…Importantly, multicomponent encapsulation into VCC is also possible and has been reported (e.g. doxorubicin and tumour-supressing microRNA 84 ).…”

Section: Caco 3 and Its Polymorphsmentioning

confidence: 99%

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

et al. 2020

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“…The entire application of nanotechnology from the synthesis processes, control release profiling, monitoring of biological processes and diagnosis is referred to as "Nano-medicine" [8]. This comprehensively means a process of transformation and encapsulation of a drug's molecules using nanostructures with or without the help of a carrier materials, masking some inherent drawbacks and limitations of free drugs such as poor bioavailability, hydrophobicity, high dosages, rapid assimilation, short half-life of photo degradation, poor selectivity as well as off targeted effects [28]. Conventional utilization of free drugs portrays poor bioavailability, low efficacy, non-selectivity and undesirable side effects [8,29].…”

Section: Nanotechnology and Nanomedicinementioning

confidence: 99%

Cockle Shell-Derived Calcium Carbonate (Aragonite) Nanoparticles: A Dynamite to Nanomedicine

et al. 2019

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Cockle shell is an external covering of small, salt water edible clams (Anadara granosa) that dwells in coastal area. This abundant biomaterial is hard, cheap and readily available with high content of calcium carbonate in aragonite polymorphic form. At present, cockle shell-derived calcium carbonate nanoparticles (CSCaCO3NPs) with dual applications has remarkably drawn significant attention of researchers in nanotechnology as a nanocarrier for delivery of different categories of drugs and as bone scaffold due to its beneficial potentials such as biocompatibility, osteoconductivity, pH sensitivity, slow biodegradation, hydrophilic nature and a wide safety margin. In addition, CSCaCO3NP possesses structural porosity, a large surface area and functional group endings for electrostatic ion bonds with high loading capacity. Thus, it maintains great potential in the drug delivery system and a large number of biomedical utilisations. The pioneering researchers adopted a non-hazardous top-down method for the synthesis of CSCaCO3NP with subsequent improvements that led to the better spherical diameter size obtained recently which is suitable for drug delivery. The method is therefore a simple, low cost and environmentally friendly, which involves little procedural steps without stringent temperature management and expensive hazardous chemicals or any carbonation methods. This paper presents a review on a few different types of nanoparticles with emphasis on the versatile most recent advancements and achievements on the synthesis and developments of CSCaCO3NP aragonite with its applications as a nanocarrier for drug delivery in nanomedicine.

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“…Nevertheless, DOX also causes toxicity in the liver, kidney and heart. Meanwhile, the damaging effects of DOX to the cardiac muscle are cumulative and irreversible, which restricted the use of DOX [29,30]. Rhein (RHE), the bioactive molecules derived from the herb rhubarb, exhibits potent anti-inflammatory and antioxidant activity, which is safe even at high doses.…”

Section: Introductionmentioning

confidence: 99%

Synergistic inhibition of metastatic breast cancer by dual-chemotherapy with excipient-free rhein/DOX nanodispersions

Wang

Yang

Yuan

et al. 2020

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Background: The treatment of metastatic cancer continues to be very challenging worldwide. Notably, excipient-free nanodispersions that are entirely composed of pharmaceutically active molecules are regarded as promising candidates for the next generation of drug formulations. These molecules are mainly formulated from the self-assembly of drug molecules that enable the safe and effective delivery of therapeutic drugs to local diseased lesions. Herein, we developed a novel and green approach for preparing nanoparticles via the self-assembly of rhein (RHE) and doxorubicin (DOX) molecules, named RHE/DOX nanoparticles (RD NPs); this assembly was associated with π−π stacking interactions and did not involve any organic solvents. Results：Molecular dynamics (MD) simulations showed that DOX molecules tend to assemble around RHE molecules through intermolecular forces. With the advantage of nanosizing, RD NPs improved the intracellular drug retention of DOX. As a dual-drug-loaded nanoformulation, the toxicity of RD NPs to tumor cells in vitro was synergistically enhanced. The combination of DOX and RHE in nanoparticles exhibited a synergistic effect with a combination index (CI) value of 0.51 and showed a stronger ability to induce cell apoptosis compared to that of free DOX. Furthermore, RD NPs treatment not only effectively suppressed primary tumor growth but also successfully inhibited tumor metastasis both in vitro and in vivo, with a good safety profile. Conclusion: The generation of pure nanodrugs via a self-assembly approach might be an option and may provide inspiration for the fabrication of new excipient-free nanodispersions, especially for two small molecular antitumor drugs that could potentially have synergistic antiproliferation effects against metastatic breast cancer.

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MiR-375 delivered by lipid-coated doxorubicin-calcium carbonate nanoparticles overcomes chemoresistance in hepatocellular carcinoma

Cited by 46 publications

References 30 publications

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

Cockle Shell-Derived Calcium Carbonate (Aragonite) Nanoparticles: A Dynamite to Nanomedicine

Synergistic inhibition of metastatic breast cancer by dual-chemotherapy with excipient-free rhein/DOX nanodispersions

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