2016
DOI: 10.18632/aging.101118
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Abstract: Both HIV and antiretroviral therapy could induce vascular aging with unclear mechanisms. In this study, via microarray analysis, we identified, for the first time, that miR-34a expression was significantly increased in both HIV-infected, and antiretroviral agents-treated vessels and vascular endothelial cells (ECs) from these vessels. In cultured ECs, miR-34a expression was significantly increased by HIV-Tat protein and by the antiretroviral agents, lopinavir/ritonavir. Both HIV-Tat protein and antiretroviral … Show more

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Cited by 21 publications
(30 citation statements)
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References 29 publications
(30 reference statements)
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“…Our finding in HAECs that Tat induces endothelial senescence and increased expression of miR‐34a compliment and extend the results of Zhan et al. () who demonstrated increased miR‐34a expression in senescent endothelial cells from HIV‐1 Tat transgenic mice. Similar to miR‐34a, miR‐217 also induces endothelial senescence through inhibition of SIRT1 (Menghini et al.…”
Section: Discussionsupporting
confidence: 91%
“…underlying the proatherogenic vascular effects of gp120 and Tat (Wang et al 2015;Zhan et al 2016;Haser and Sumpio 2017). Future studies are needed to elucidate how these HIV-1 proteins differentially disrupt cellular miR expression patterns and, in turn, compromise target proteins that regulate endothelial cell viability and function.…”
Section: Discussionmentioning
confidence: 99%
“…In the present study, we identified the adverse effects of NRTIs, the most common class of ART in HIV infection, on vascular growth and development. In addition to the endothelial injury in arteriosclerosis, as the major concern of ART treatment, recent studies have also demonstrated other side effects of ART, such as endothelial cell senescence, renal endothelial dysfunction, endothelial activation and effects on endothelial progenitor cells (Zhan et al, ; Zungsontiporn et al, ; Echeverria et al, ; Meneses et al, ). However, few studies have referred to the effect of ART on angiogenic capability of endothelial cells.…”
Section: Discussionmentioning
confidence: 99%
“…Tat has also been shown to affect the expression of some miRNAs in neurons. For instance, Tat upregulates the expression of miR-34a, a miRNA that targets CREB (Zhang et al, 2012;Zhan et al, 2016). The upregulation of miR-34a leads to the promotion of neuronal dysfunction (Hu et al, 2017;Periyasamy et al, 2019).…”
Section: Mechanism Of Neurotoxicitymentioning
confidence: 99%
“…Mir-34a up-regulation, the reciprocal decline of its target SIRT1, is the biomarker for aging in the brain and a good predictor of deterioration of the brain function. The miR-34a expression is significantly increased in HIV-infected vascular endothelial cells (ECs) [126] as well as in primary neuronal cultures and neuronal cell lines [127]. MiR-146a was also up-regulated in these cells.…”
Section: Micrornamentioning
confidence: 99%