“…In the present study, we identified the adverse effects of NRTIs, the most common class of ART in HIV infection, on vascular growth and development. In addition to the endothelial injury in arteriosclerosis, as the major concern of ART treatment, recent studies have also demonstrated other side effects of ART, such as endothelial cell senescence, renal endothelial dysfunction, endothelial activation and effects on endothelial progenitor cells (Zhan et al, ; Zungsontiporn et al, ; Echeverria et al, ; Meneses et al, ). However, few studies have referred to the effect of ART on angiogenic capability of endothelial cells.…”