miR-339-3p Is a Tumor Suppressor in Melanoma

Weber, Claudia E.M.; Luo, Chonglin; Hotz‐Wagenblatt, Agnes; Gardyan, Adriane; Kordaß, Theresa; Holland‐Letz, Tim; Osen, Wolfram; Eichmüller, Stefan B.

doi:10.1158/0008-5472.can-15-2932

Cited by 71 publications

(67 citation statements)

References 56 publications

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“…Aberrant expression of 5 miRNAs reported in this study (miRNA-3615, miRNA-342, miRNA-339, miRNA-182, and miRNA-4485) has been previously reported in relation to liver cirrhosis or HCC malignancy (29) as well as some other cancers such as lung adenocarcinoma (30) , melanoma (31) , colorectal cancer (32) (33) , gastric cancer (34) (35) , intrahepatic cholangiocarcinoma (36) , colon cancer (37) , and breast cancer (38) (39) . Recently Wojcicka et al employed next generation sequencing to investigate the expression of microRNA in tissue samples of HBV/HCV infected with liver cirrhosis and HCC.…”

Section: Discussionsupporting

confidence: 76%

Circulating microRNA as a marker for predicting liver disease progression in patients with chronic hepatitis B

Riazalhosseini

Mohamed

Apalasamy

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: Hepatitis B virus (HBV) constitutes an important risk factor for cirrhosis and hepatocellular carcinoma (HCC). The link between circulating microRNAs and HBV has been previously reported, although not as a marker of liver disease progression in chronic hepatitis B (CHB). The aim of this study was to characterize miRNA expression profiles between CHB with and without cirrhosis or HCC. Methods: A total of 12 subjects were recruited in this study. We employed an Affymetrix Gene Chip miRNA 3.0 Array to provide universal miRNA coverage. We compared microRNA expression profiles between CHB with and without cirrhosis/HCC to discover possible prognostic markers associated with the progression of CHB. Results: Our results indicated 8 differently expressed microRNAs, of which miRNA-935, miRNA-342, miRNA-339, miRNA-4508, miRNA-3615, and miRNA-3200 were up-regulated, whereas miRNA-182 and miRNA-4485 were down-regulated in patients with CHB who progressed to cirrhosis/HCC as compared to those without progression. Conclusions: We demonstrated the differential expression of between patients with HBV without cirrhosis/HCC and those who had progressed to these more severe conditions. These miRNAs may serve as novel and non-invasive prognostic markers for early detection of CHB-infected patients who are at risk of progression to cirrhosis and/or HCC.

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Section: Discussionsupporting

confidence: 76%

Circulating microRNA as a marker for predicting liver disease progression in patients with chronic hepatitis B

Riazalhosseini

Mohamed

Apalasamy

et al. 2017

Rev. Soc. Bras. Med. Trop.

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“…Many studies have shown that miRNAs can act either as tumor suppressors or oncogenes in various cancers through regulating target gene expression by binding 3′ untranslated regions and repressing transcription [6, 7]. Recently, lncRNAs have drawn attention as potential biological regulators involved in a wide range of cellular activities such as cell proliferation, apoptosis, migration, and invasion [8].…”

Section: Introductionmentioning

confidence: 99%

Long intergenic non-coding RNA 00152 promotes lung adenocarcinoma proliferation via interacting with EZH2 and repressing IL24 expression

et al. 2017

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BackgroundNumerous studies have shown that long non-coding RNAs (lncRNAs) behave as a novel class of transcript during multiple cancer processes, such as cell proliferation, apoptosis, migration, and invasion. LINC00152 is located on chromosome 2p11.2, and has a transcript length of 828 nucleotides. The biological role of LINC00152 in LAD(lung adenocarcinoma) remains unknown.MethodsQuantitative reverse transcription PCR(qRT-PCR) was used to detect LINC00152 expression in 60 human LAD tissues and paired normal tissues. In vitro and in vivo studies showed the biological function of LINC00152 in tumour progression. RNA transcriptome sequencing technology was performed to identify the downstream suppressor IL24(interleukin 24) which was further examined by qRT-PCR, western bolt and rescue experiments. RNA immunoprecipitation (RIP), RNA pulldown, and Chromatin immunoprecipitation (ChIP) assays were carried out to reveal the interaction between LINC00152, EZH2 and IL24.ResultsLINC00152 expression was upregulated in 60 human LAD tissues and paired normal tissues. High levels of LINC00152 expression were correlated with advanced TNM stage, larger tumor size, and lymph node metastasis, as well as shorter survival time. Silencing of LINC00152 suppressed cell growth and induced cell apoptosis. LINC00152 knockdown altered the expression of many downstream genes, including IL24. LINC00152 could interact with EZH2 and inhibit IL24 transcription. Moreover, the ectopic expression of IL24 repressed cell proliferation and partly reversed LINC00152 overexpression-induced promotion of cell growth in LAD.ConclusionsOur study reveals an oncogenic role for LINC00152 in LAD tumorigenesis, suggesting that it could be used as a therapeutic target in LAD treatment.Electronic supplementary materialThe online version of this article (doi:10.1186/s12943-017-0581-3) contains supplementary material, which is available to authorized users.

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“…Generally, miRNAs bind to messenger RNAs’ (mRNAs) 3′ untranslated region (3′ UTR), which result in the degradation or translated inhibition of mRNA [5]. Emerging evidence suggests that altered expressions of miRNAs are implicated in various tumor biological process, such as cell growth, proliferation, angiogenesis, migration, invasion and so forth, via regulating targeted genes, [6–8]. Kong et al demonstrated that miR-511, acting as tumor suppressor, could inhibited the abilities of proliferation of GC via targeting TRIM24 [9].…”

Section: Introductionmentioning

confidence: 99%

miR-509-3-5P inhibits the invasion and lymphatic metastasis by targeting PODXL and serves as a novel prognostic indicator for gastric cancer

Zhang

Zhu

Sheng³

et al. 2017

Oncotarget

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BackgroundOur study aimed to investigate the clinicopathological feature and prognostic role of miR-509-3-5P in gastric cancer, to determine the invasive and metastatic role of miR-509-3-5P in vitro and in vivo and to explore the molecular mechanism between miR-509-3-5P and PODXL.ResultsStrikingly lower miR-509-3-5P expression was detected in gastric cancer tissues with advanced tumor stage, poor differentiation and advanced pT stage, and was regarded as an independent prognostic role for poor prognosis. MiR-509-3-5P expression was markedly down-regulated in gastric cancer cell lines and tissues comparing with normal gastric cell and adjacent normal tissues, respectively. Decreased expression of miR-509-3-5P promoted the colony, migration and invasion abilities of gastric cancer cells in vitro as well as tumorigenesis and lymph node metastasis in vivo. Based on the luciferase assay and tissue microarray, PODXL was regarded as a target gene of miR-509-3-5P.Materials and MethodsThe expression of miR-509-3-5P in gastric cancer patients and its clinicopathological relationships as well as prognostic role was studied employing tissue microarray; qRT-PCR was applied to explore miR-509-3-5P expression in gastric cancer cell lines and samples. Moreover, public database was used to analyze the expression of miR-509-3-5P and PODXL. Functional and molecular mechanism experiments were performed in vitro and in vivo.ConclusionsOverexpression of miR-509-3-5P inhibits the invasion and metastasis of gastric cancer in vitro and in vivo, functioning as a tumor suppressor, by targeting PODXL. More importantly, miR-509-3-5P was downregulated in gastric cancer tissues and may serve as a novel prognostic indicator for gastric cancer.

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miR-339-3p Is a Tumor Suppressor in Melanoma

Cited by 71 publications

References 56 publications

Circulating microRNA as a marker for predicting liver disease progression in patients with chronic hepatitis B

Circulating microRNA as a marker for predicting liver disease progression in patients with chronic hepatitis B

Long intergenic non-coding RNA 00152 promotes lung adenocarcinoma proliferation via interacting with EZH2 and repressing IL24 expression

miR-509-3-5P inhibits the invasion and lymphatic metastasis by targeting PODXL and serves as a novel prognostic indicator for gastric cancer

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