miR-320a mediates doxorubicin-induced cardiotoxicity by targeting VEGF signal pathway

Abstract

BackgroundVascular homeostasis abnormalities may involve in doxorubicin induced cardiotoxicity.MethodsEnhanced cardiac miR-320a expression, reduced cardiac microvessel density and impaired cardiac function were observed in mice treated by anthracycline doxorubicin. To further explore the role of miR-320a in doxorubicin induced cardiotoxicity, microRNA mimics/inhibitor in vitro and rAAV administration in vivo were employed in mice.ResultsKnockdown of miR-320a not only resulted in enhanced proliferation and inhi…