2016
DOI: 10.18632/aging.100876 View full text |Buy / Rent full text
Has erratum 2021-6-30
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Abstract: BackgroundVascular homeostasis abnormalities may involve in doxorubicin induced cardiotoxicity.MethodsEnhanced cardiac miR-320a expression, reduced cardiac microvessel density and impaired cardiac function were observed in mice treated by anthracycline doxorubicin. To further explore the role of miR-320a in doxorubicin induced cardiotoxicity, microRNA mimics/inhibitor in vitro and rAAV administration in vivo were employed in mice.ResultsKnockdown of miR-320a not only resulted in enhanced proliferation and inhi… Show more

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