2022
DOI: 10.3389/fonc.2022.957511
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Abstract: IntroductionAdenylyl cyclase isoform 6 (ADCY6) is a member of membrane-bound adenylate cyclase family that converts adenosine triphosphate (ATP) into cAMP and pyrophosphate. An increasing number of researchers have studied the role of ADCY6 in cancer. However, its specific role in breast cancer remains unknown.MethodsBioinformatics and clinical data were used to analyse the expression of ADCY6 in breast cancer. ADCY6 DNA methylation was analysed using DNA methylation-specific PCR and Bisulfite Sanger sequencin… Show more

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Cited by 5 publications
(2 citation statements)
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“…12 In breast cancer, ADCY6 is regulated by DNA methylation of miR-27a-3p/TET1 regulatory axis, which affects malignant biological behavior of tumor cells through EMT. 13 However, the role of ADCY6 in a variety of malignant tumors is still unknown, and its role in OTSCC has not been reported.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…12 In breast cancer, ADCY6 is regulated by DNA methylation of miR-27a-3p/TET1 regulatory axis, which affects malignant biological behavior of tumor cells through EMT. 13 However, the role of ADCY6 in a variety of malignant tumors is still unknown, and its role in OTSCC has not been reported.…”
Section: Introductionmentioning
confidence: 99%
“…Increasing evidence has proven that ADCY6 is involved in pathophysiological processes of the body, such as the stability of cardiovascular system function, glucose and lipid metabolism, and even carcinogenesis 12 . In breast cancer, ADCY6 is regulated by DNA methylation of miR‐27a‐3p/TET1 regulatory axis, which affects malignant biological behavior of tumor cells through EMT 13 . However, the role of ADCY6 in a variety of malignant tumors is still unknown, and its role in OTSCC has not been reported.…”
Section: Introductionmentioning
confidence: 99%