RETRACTED: MiR-211 plays a dual role in cancer development: From tumor suppressor to tumor enhancer

Shirvani, Hanieh; Ghanavi, Jalaledin; Aliabadi, Amin; Mousavinasab, Fatemehsadat; Talebi, Mehrdad; Majidpour, Jamal; Najafi, Sajad; Miryounesi, Seyyed Mohammad; Zarch, Seyed Mohsen Aghaei

doi:10.1016/j.cellsig.2022.110504

Cited by 29 publications

(12 citation statements)

References 85 publications

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“…MiRNAs have recently been suggested as prospective therapeutic candidates as cancer therapy [ 95 ]. Tumor repressor miRNAs are a promising candidate for developing cancer treatments due to their regulatory capacity, which permits modulation of whole signaling pathways inside the cells.…”

Section: Mir-122 and Cancer Stem Cellmentioning

confidence: 99%

“…MicroRNAs (miRNAs) are small noncoding RNAs of approximately 22 nucleotide (nt) that are known to have a significant role in the regulation of the post-transcriptional level of messenger RNAs (mRNAs) [ 1 , 2 ]. MiRNAs are 22 nt noncoding RNAs recognized to play a crucial function in the post-transcriptional control of mRNA [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

et al. 2023

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MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological functions, and abnormal miRNA expression has been linked to various illnesses, including cancer. Among the miRNAs, miR-122, miR-206, miR-21, miR-210, miR-223, and miR-424 have been extensively studied in various cancers. Although research in miRNAs has grown considerably over the last decade, much is yet to be discovered, especially regarding their role in cancer therapies. Several kinds of cancer have been linked to dysregulation and abnormal expression of miR-122, indicating that miR-122 may serve as a diagnostic and/or prognostic biomarker for human cancer. Consequently, in this review literature, miR-122 has been analyzed in numerous cancer types to sort out the function of cancer cells miR-122 and enhance patient response to standard therapy.

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Section: Mir-122 and Cancer Stem Cellmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

et al. 2023

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“…It can target the specific sequence of 3 ‘-UTRs of mRNA and inhibit mRNA expression, thus playing an important role in various human tumor diseases [ 10 , 12 ]. Because the expression profile of miRNA is more successful in classifying tumors that are close in composition than mRNA expression profiles [ 13 ], miRNA can be used as a biomarker for the diagnosis and prognosis of tumors [ 12 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…MicroRNAs are endogenous non-coding RNAs, which lead to the target gene mRNA degradation or restrain their translation via specific mRNA complementary pairing of target genes [ 13 , 29 ]. miRNAs modulate multiple pivotal biological functions, including differentiation, drug resistance proliferation, apoptosis, migration, as well as invasion via mediating gene expression [ 30 – 32 ].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, miRNAs can be used as one of the indicators of tumor detection [ 35 ]. Because RNAs are easily degraded outside the cell [ 36 ], and miRNAs are not one-to-one corresponding to tumors [ 13 ], further research in this field is limited. It is worth noting that there are many kinds of exosomal RNAs, among which miRNAs are the most abundant [ 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

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Advances of exosomal miRNAs in the diagnosis and treatment of ovarian cancer

Xiong

et al. 2023

Discov Onc

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Ovarian cancer is a tumor with the highest fatalities among female malignant tumors. This disease has no typical symptoms in its early stage, and most of the patients are in an advanced stage when being treated. The treatment effect is poor and it is easy to develop chemotherapy resistance. Therefore, it is particularly urgent to clarify the pathogenesis of ovarian cancer, explore its early diagnosis of biomarkers, and discover new treatment methods. As a carrier of intercellular information and genetic material transfer, exosomes are widely distributed in body fluids (e.g. blood and urine), which are regarded as latent tumor markers and take effects on tumor occurrence and invasion. Several articles have recently signified that exosomal miRNAs are widely implicated in the formation of the ovarian cancer tumor microenvironment, disease initiation and progression, and the generation of chemotherapy resistance. This article reviews the research on exosomal miRNAs in ovarian cancer.

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