Arthritis Res Ther 2018 DOI: 10.1186/s13075-018-1550-y View full text Has correction 2018-08-14
Qibin Yang, Quanbo Zhang, Yufeng Qing, Li Zhou, Qingsheng Mi, Jingguo Zhou

Abstract: BackgroundThe findings of a previous study by Jin et al. have shown that microRNA (miR)-155 was upregulated in patients with acute gouty arthritis and enhanced the proinflammatory cytokines. There is no direct evidence to support that miR-155 is indeed involved in monosodium urate (MSU)-induced inflammatory responses in vivo. The aim of this study was to investigate the role of miR-155 knock-out (KO) or knock-in (KI) mice in MSU-induced animal models to mimic acute gout.MethodsMiR-155 expression in cultured bo…

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