MiR-150-5p protects against septic acute kidney injury via repressing the MEKK3/JNK pathway

Shi, Lang; Zhang, Yafei; Xia, Yao; Li, Chenglong; Song, Zhixia; Zhu, Jiefu

doi:10.1016/j.cellsig.2021.110101

Cited by 42 publications

(36 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This review did not identify direct analyses of inflammasome components in human S-AKI. Increased concentrations of serum IL-1β protein concentration in S-AKI have been reported [ 172 , 173 ]. On the other hand, elevations of IL-1β serum concentrations in human sepsis can be mild [ 174 ] or irregular [ 175 ], are dependent on the phase of septic state [ 176 ], and, in addition, the kidney has a role in IL-1β removal in sepsis as long as diuresis is preserved [ 177 ].…”

Section: Inflammasome Components In Akimentioning

confidence: 99%

Involvement of Inflammasome Components in Kidney Disease

et al. 2022

View full text Add to dashboard Cite

Inflammasomes are multiprotein complexes with an important role in the innate immune response. Canonical activation of inflammasomes results in caspase-1 activation and maturation of cytokines interleukin-1β and -18. These cytokines can elicit their effects through receptor activation, both locally within a certain tissue and systemically. Animal models of kidney diseases have shown inflammasome involvement in inflammation, pyroptosis and fibrosis. In particular, the inflammasome component nucleotide-binding domain-like receptor family pyrin domain containing 3 (NLRP3) and related canonical mechanisms have been investigated. However, it has become increasingly clear that other inflammasome components are also of importance in kidney disease. Moreover, it is becoming obvious that the range of molecular interaction partners of inflammasome components in kidney diseases is wide. This review provides insights into these current areas of research, with special emphasis on the interaction of inflammasome components and redox signalling, endoplasmic reticulum stress, and mitochondrial function. We present our findings separately for acute kidney injury and chronic kidney disease. As we strictly divided the results into preclinical and clinical data, this review enables comparison of results from those complementary research specialities. However, it also reveals that knowledge gaps exist, especially in clinical acute kidney injury inflammasome research. Furthermore, patient comorbidities and treatments seem important drivers of inflammasome component alterations in human kidney disease.

show abstract

Section: Inflammasome Components In Akimentioning

confidence: 99%

Involvement of Inflammasome Components in Kidney Disease

et al. 2022

View full text Add to dashboard Cite

show abstract

“…miR-150-5p interacts with X-inactive specific transcript lncRNA to regulate the c-Fos axis, thioredoxin-interacting protein-mediated pyroptosis and sepsis-induced myocardial injury (157). In sepsis mice with acute kidney injury (AKI), miR-150 targets MEKK3, inhibits LPS-induced c-Jun Nterminal kinase (JNK) pathway, apoptosis and inflammation (156). miR-150 -/mice show increased mortality from LPS and CLP.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Modes of action and diagnostic value of miRNAs in sepsis

et al. 2022

View full text Add to dashboard Cite

Sepsis is a clinical syndrome defined as a dysregulated host response to infection resulting in life-threatening organ dysfunction. Sepsis is a major public health concern associated with one in five deaths worldwide. Sepsis is characterized by unbalanced inflammation and profound and sustained immunosuppression, increasing patient susceptibility to secondary infections and mortality. microRNAs (miRNAs) play a central role in the control of many biological processes, and deregulation of their expression has been linked to the development of oncological, cardiovascular, neurodegenerative and metabolic diseases. In this review, we discuss the role of miRNAs in sepsis pathophysiology. Overall, miRNAs are seen as promising biomarkers, and it has been proposed to develop miRNA-based therapies for sepsis. Yet, the picture is not so straightforward because of the versatile and dynamic features of miRNAs. Clearly, more research is needed to clarify the expression and role of miRNAs in sepsis, and to promote the use of miRNAs for sepsis management.

show abstract

“…Lang Shi and colleagues identified the MEKK3/JNK pathway as a target of miR-150-5p, eliciting a protective effect against LPS-mediated HK-2 cell apoptosis. During AKI with sepsis, Stat-3 activation mediated the decrease in miR-150-5p, which enhanced renal injury [ 270 ].…”

Section: Resultsmentioning

confidence: 99%

Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review

Maiese

Scatena

Costantino

et al. 2022

IJMS

View full text Add to dashboard Cite

Sepsis is a critical condition characterized by increased levels of pro-inflammatory cytokines and proliferating cells such as neutrophils and macrophages in response to microbial pathogens. Such processes lead to an abnormal inflammatory response and multi-organ failure. MicroRNAs (miRNA) are single-stranded non-coding RNAs with the function of gene regulation. This means that miRNAs are involved in multiple intracellular pathways and thus contribute to or inhibit inflammation. As a result, their variable expression in different tissues and organs may play a key role in regulating the pathophysiological events of sepsis. Thanks to this property, miRNAs may serve as potential diagnostic and prognostic biomarkers in such life-threatening events. In this narrative review, we collect the results of recent studies on the expression of miRNAs in heart, blood, lung, liver, brain, and kidney during sepsis and the molecular processes in which they are involved. In reviewing the literature, we find at least 122 miRNAs and signaling pathways involved in sepsis-related organ dysfunction. This may help clinicians to detect, prevent, and treat sepsis-related organ failures early, although further studies are needed to deepen the knowledge of their potential contribution.

show abstract

MiR-150-5p protects against septic acute kidney injury via repressing the MEKK3/JNK pathway

Cited by 42 publications

References 22 publications

Involvement of Inflammasome Components in Kidney Disease

Involvement of Inflammasome Components in Kidney Disease

Modes of action and diagnostic value of miRNAs in sepsis

Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review

Contact Info

Product

Resources

About