Am J Dis Child
 1987
DOI: 10.1001/archpedi.1987.04460090024014
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Minor Malformations

H. Eugene Hoyme1
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Cited by 16 publications

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“…We excluded patients with preterm birth, small for gestational age, and significant signs of malformation, including severe malformation, microcephaly, neurodevelopmental delay, intellectual disability, or skeletal dysplasia [ 11 ]. We did not exclude patients with minor malformations, defined as unusual morphological features found in the general population that have no serious medical or cosmetic significance for the affected individual [ 12 ]. In addition, participants with identified causes of short stature or chromosomal abnormalities or those for which DNA samples were not available were excluded from this study Figs.…”
Section: Methodsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…We excluded patients with preterm birth, small for gestational age, and significant signs of malformation, including severe malformation, microcephaly, neurodevelopmental delay, intellectual disability, or skeletal dysplasia [ 11 ]. We did not exclude patients with minor malformations, defined as unusual morphological features found in the general population that have no serious medical or cosmetic significance for the affected individual [ 12 ]. In addition, participants with identified causes of short stature or chromosomal abnormalities or those for which DNA samples were not available were excluded from this study Figs.…”
Section: Methodsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Patients with several dysmorphic features or major malformations, indicative of a syndrome were excluded from this study. 'Minor malformations' refers to unusual morphologic features found in the general population causing no serious medical or cosmetic significance to the affected individual (17). Following this concept, we define mild skeletal defects as unusual skeletal features both unpainful and non-disabling for the affected individual (see list in Supplementary Table 1, see section on supplementary materials given at the end of this article).…”
Section: Study Subjectsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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