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Cited by 50 publications
(27 citation statements)
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“…Shamsi Fatemeh et al found that minocycline distinctly inhibits the proliferation of neural stem/progenitor cells (NS/PC), but has little effect on cell differentiation (Fatemeh et al, 2019). Minocycline treatment reduces brain damage in the animal cerebral cortex, brain stem, and dampens tumor necrosis factor, interferon-γ, interleukin-6, interleukin-10, and interleukin-12 (Camargos et al, 2020). The above results suggest that MC is an analgesic for NP, and the mechanism may be related to the inhibition of inflammatory factors.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Shamsi Fatemeh et al found that minocycline distinctly inhibits the proliferation of neural stem/progenitor cells (NS/PC), but has little effect on cell differentiation (Fatemeh et al, 2019). Minocycline treatment reduces brain damage in the animal cerebral cortex, brain stem, and dampens tumor necrosis factor, interferon-γ, interleukin-6, interleukin-10, and interleukin-12 (Camargos et al, 2020). The above results suggest that MC is an analgesic for NP, and the mechanism may be related to the inhibition of inflammatory factors.…”
Section: Discussionmentioning
confidence: 99%
“…Zhang et al found that microglia and its IL-18 signaling pathway are related to mechanical pain, and intrathecal injection of minocycline blocks IL-18 signaling and weakens pain perception. Other researchers also found minocycline reduces the release of glutamate and blocks the sodium channel to relieve pain (Camargos et al, 2020). Therefore, minocycline has a good analgesic effect on NP by attenuating the inflammatory response of glial cells.…”
Section: Introductionmentioning
confidence: 95%
“…The knockdown of IL 1β expression in the hippocampus with a virus encoded shRNA reduced the signs of the depression like behavior and anxiety and alleviated memory loss induced by LPS [51]. Administration of tetracycline antibiotic minocy cline to mice with ischemia interfered with neuroinflam mation and alleviated depression like behavior and anxi ety in the animals [52].…”
Section: Role Of Neuroinflammation In Post Stroke Disordersmentioning
confidence: 99%
“…The antioxidant components of Green tea such as polyphenol, theanine, glutamine and caffeine have also been shown to be beneficial for PSD [234]. Minocycline, on the other hand, has also been studied for the treatment of depression in mice with global cerebral ischemia [235]. This is likely secondary to the upregulation of neuroprotective cytokines and the reduction of hippocampal degeneration [235].…”
Section: Antioxidants and Other Anti-inflammatory Medications For Psdmentioning
confidence: 99%
“…Minocycline, on the other hand, has also been studied for the treatment of depression in mice with global cerebral ischemia [235]. This is likely secondary to the upregulation of neuroprotective cytokines and the reduction of hippocampal degeneration [235]. These observations and theoretical…”
Section: Antioxidants and Other Anti-inflammatory Medications For Psdmentioning
confidence: 99%