J. Neurosci. Res. volume 85, issue 11, P2450-2459 2007 DOI: 10.1002/jnr.21380 View full text
Sergey G. Kremlev, Rebecca L. Roberts, Charles Palmer

Abstract: Hypoxic-ischemic (HI) brain injury in the perinatal period causes significant morbidity. Minocycline (MN) is a tetracycline derivative that has reduced brain injury in various animal models of neurodegeneration, including perinatal ischemia. To determine whether MN can modulate the expression of chemokine receptors and interleukin-10 (IL10) in a model of neonatal brain injury, we produced an HI insult to the right cerebral hemisphere (ipsilateral) of the 7-day-old rat (PD7) by right common carotid artery ligat…

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