Minocycline Hypersensitivity With Respiratory Failure

Clayton, Beth D.; Hitchcock, Michael G.; Williford, Phillip M.

doi:10.1001/archderm.135.2.139

Cited by 13 publications

(2 citation statements)

References 11 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 1975, exanthema was reported in 86 of the 22,500 patients taking minocycline by Lederle Laboratories, the original manufacturer of minocycline [32]. Minocycline has been associated with a 13.6% incidence of adverse effects, ranging from nausea and vomiting to drug-hypersensitivity syndrome [33]. Between 1998 and 2003, 72 adverse events per million prescriptions of minocycline were reported by the FDA.…”

Section: Resultsmentioning

confidence: 99%

Tetracycline Allergy

Hamilton

Guarascio

2019

Pharmacy

View full text Add to dashboard Cite

Despite the widespread use of tetracycline antibiotics since the late 1940s, tetracycline hypersensitivity reactions have rarely been described in the literature. A comprehensive PubMed search was performed, including allergic and serious adverse reactions attributed to the tetracyclines class of antibiotics. Of the evaluated tetracycline analogs, minocycline was attributed to the greatest overall number and severity of serious adverse events reported in the literature, with notable reactions primarily reported as respiratory and dermatologic in nature. Reactions to tetracycline have also been well described in the literature, and although dermatologic reactions are typically less severe in comparison with minocycline and doxycycline, various reports of anaphylactic reactions exist. Although doxycycline has been noted to have had the fewest reports of severe allergic reactions, rare descriptions of life-threatening reactions are still reported in the literature. Allergic reactions regarding tetracyclines are rare; however, adverse reaction type, severity, and frequency among different tetracycline analogs is somewhat variable. A consideration of hypersensitivity and adverse reaction incidence should be performed prior to the selection of individual tetracycline entities.

show abstract

Section: Resultsmentioning

confidence: 99%

Tetracycline Allergy

Hamilton

Guarascio

2019

Pharmacy

View full text Add to dashboard Cite

show abstract

“…Common adverse effects of minocycline include gastrointestinal disturbances (nausea and vomiting), vestibular disturbance (dizziness), and cutaneous symptoms (hyperpigmentation of skin and mucous membranes, pruritis, urticaria, and photosensitive rash). Serious but rare adverse effects of minocycline include pneumonitis, hepatitis, pancreatitis, nephritis, polyarthritis, serum sickness-like reaction, drug-induced lupus erythematosus-like eruption, and hypersensitivity syndrome (6, 7). …”

Section: Introductionmentioning

confidence: 99%

A Case of Anaphylaxis to Oral Minocycline

et al. 2010

View full text Add to dashboard Cite

Minocycline is a semisynthetic tetracycline derivative that is often used in the treatment of acne vulgaris. To date, there has been only one case report of anaphylaxis to minocycline. We report here a case of anaphylaxis to oral minocycline. A 56-yr-old woman visited our hospital after three episodes of recurrent anaphylaxis. We performed an oral challenge test, the standard method for diagnosing drug allergies, with minocycline, one of the drugs she had taken previously. She developed urticaria, angioedema, nausea, vomiting, hypotension, and dyspnea within 4 min and was treated with intramuscular epinephrine, intravenous antihistamine and systemic corticosteroid. However, she presented similar symptoms at 50 min and at 110 min. In prescribing oral minocycline, physicians should consider the possibility of serious adverse reactions, such as anaphylaxis.

show abstract