Minocycline attenuates noise-induced hearing loss in rats

Zhang, Jing; Song, Yongli; Tian, Keyong; Qiu, Jianhua

doi:10.1016/j.neulet.2016.12.039

Cited by 11 publications

(10 citation statements)

References 29 publications

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“…Similar to our finding, other study also reported minocycline protecting cochlear damage in gerbils in chemical induced hearing loss ( Robinson et al., 2015 ) and also in noise-induced hearing loss (NIHL) ( Zhang et al., 2017 ). What's more, minocycline treatment can also reduce noisy environment induces neuroinflammation ( Lin et al., 2020 ).…”

Section: Resultssupporting

confidence: 92%

“…Another potential drug for treating hearing loss is Minocycline, an FDA approved semi-synthetic tetracycline derivative, has both anti-inflammatory and neuroprotective properties ( Zhang et al., 2017 ; Gupta et al., 2020 ). It is tetracycline derivative that has antimicrobial, anti-inflammatory, anti-oxidant, antiapoptotic properties and identified with various neuroprotective properties ( Camargos et al., 2020 ; Hiskens et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Effect of minocycline and its nano-formulation on central auditory system in blast-induced hearing loss rat model

Perumal¹,

Ravula²,

Shao³

et al. 2023

Journal of Otology

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Effect of minocycline and its nano-formulation on central auditory system in blast-induced hearing loss rat model

Perumal¹,

Ravula²,

Shao³

et al. 2023

Journal of Otology

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“…Metabolic theory is recognized as one of the three main mechanisms of noise-induced damage to the auditory system. Noise exposure leads to excessive free radicals, lipid peroxidation, glutamic acid excitatory toxicity, and calcium overload, resulting in mitochondrial damage; protein, lipid, and DNA damage; serious disorders of hair cells and Sertoli cell enzymes; oxygen and energy metabolism disorders; cell necrosis and apoptosis; all these factors ultimately lead to degeneration, death, and loss of inner ear cells and neurons (Zhang et al, 2017). Several studies have confirmed that noise-induced excessive free radicals in the cochlea and auditory cortex play an important role in the occurrence and development of NIHL (Tuerdi et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rd Ameliorates Auditory Cortex Injury Associated With Military Aviation Noise-Induced Hearing Loss by Activating SIRT1/PGC-1α Signaling Pathway

Chen

Liu

et al. 2020

Front. Physiol.

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Free radicals and oxidative stress play an important role in the pathogenesis of noiseinduced hearing loss (NIHL). Some ginseng monomers showed certain therapeutic effects in NIHL by scavenging free radicals. Therefore, we hypothesized that ginsenoside Rd (GSRd) may exert neuroprotective effects after noise-induced auditory system damage through a mechanism involving the SIRT1/PGC-1α signaling pathway. Fortyeight guinea pigs were randomly divided into four equal groups (normal control group, noise group, experimental group that received GSRd dissolved in glycerin through an intraperitoneal injection at a dose of 30 mg/kg body weight from 5 days before noise exposure until the end of the noise exposure period, and experimental control group). Hearing levels were examined by auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). Hematoxylin-eosin and Nissl staining were used to examine neuron morphology. RT-qPCR and western blotting analysis were used to examine SIRT1/PGC-1α signaling and apoptosis-related genes, including Bax and Bcl-2, in the auditory cortex. Bax and Bcl-2 expression was assessed via immunohistochemistry analysis. Superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH-Px) levels were determined using a commercial testing kit. Noise exposure was found to up-regulate ABR threshold and down-regulate DPOAE amplitudes, with prominent morphologic changes and apoptosis of the auditory cortex neurons (p < 0.01). GSRd treatment restored hearing loss and remarkably alleviated morphological changes or apoptosis (p < 0.01), concomitantly increasing Bcl-2 expression and decreasing Bax expression (p < 0.05). Moreover, GSRd increased SOD and GSH-Px levels and decreased MDA levels, which alleviated oxidative stress

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“…1). NIHL is a type of illness characterized by oxidative stress damage and apoptosis progression [42]. Previous results have demonstrated that GSRd can signi cantly reverse the increase in the auditory brainstem response threshold caused by noise stimulation (Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

Protective Effect of Ginsenoside Rd on Military Aviation Noise-Induced Cochlear Hair Cell Damage

Chen

Y²,

et al. 2021

Preprint

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Background Soldiers are often exposed to high-intensity noise produced by military weapons and equipment during activities, and the incidence of noise-induced hearing loss (NIHL) in many arms is high. Oxidative stress has a significant role in the pathogenesis of NIHL, and research has confirmed that ginsenoside Rd (GSRd) suppresses oxidative stress. Therefore, we hypothesized that GSRd may attenuate NIHL and cochlear hair cell loss, induced by military aviation noise stimulation, through the Sirtuin1/proliferator-activated receptor-gamma coactivator 1α (SIRT1/PGC-1α) signaling pathway.Methods Forty-eight male guinea pigs were randomly divided into four groups: control, noise stimulation, GSRd, and glycerol. The experimental groups received military helicopter noise stimulation at 115 dB (A) for 4 h daily for five consecutive days. Hair cell damage was evaluated by using inner ear basilar membrane preparation and scanning electron microscopy. Terminal dUTP nick end labeling and immunofluorescence staining were conducted. Changes in the SIRT1/PGC-1α signaling pathway and other apoptosis-related markers in the cochleae, as well as oxidative stress parameters were used as readouts.Results Loss of outer hair cells, more disordered cilia, prominent apoptosis, and elevated free radical levels were observed in the experimental groups. GSRd treatment markedly improved morphological changes and apoptosis through decreasing Bcl-2 associated X protein (Bax) expression and increasing Bcl-2 expression. In addition, GSRd upregulated superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels, decreased malondialdehyde (MDA) levels, and enhanced the activity of SIRT1 and PGC-1α messenger ribonucleic acid and protein expression.Conclusion GSRd can improve structural and functional damage to the cochleae caused by noise. The underlying mechanisms may be associated with the SIRT1/PGC-1α signaling pathway.

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Minocycline attenuates noise-induced hearing loss in rats

Cited by 11 publications

References 29 publications

Effect of minocycline and its nano-formulation on central auditory system in blast-induced hearing loss rat model

Effect of minocycline and its nano-formulation on central auditory system in blast-induced hearing loss rat model

Ginsenoside Rd Ameliorates Auditory Cortex Injury Associated With Military Aviation Noise-Induced Hearing Loss by Activating SIRT1/PGC-1α Signaling Pathway

Protective Effect of Ginsenoside Rd on Military Aviation Noise-Induced Cochlear Hair Cell Damage

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