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Cited by 382 publications
(281 citation statements)
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“…Transitions among different conformations are regulated by endogenous molecules such as ATP and may be affected by synthetic molecules such as minocycline. Minocycline has been shown to have neuroprotective effects in animal models of neurodegenerative diseases [7,25,26]. Our findings suggest as minocycline may have a twofold effect on cyt c apoptotic role: a former effect due to its potency in avoiding or decreasing the peroxidase activity of cyt c in the early stages of apoptosis and a later effect related to its competition in cyt c-Apaf-1 binding interaction in the cytosol.…”
Section: Discussionmentioning
confidence: 67%
See 1 more Smart Citation
“…Transitions among different conformations are regulated by endogenous molecules such as ATP and may be affected by synthetic molecules such as minocycline. Minocycline has been shown to have neuroprotective effects in animal models of neurodegenerative diseases [7,25,26]. Our findings suggest as minocycline may have a twofold effect on cyt c apoptotic role: a former effect due to its potency in avoiding or decreasing the peroxidase activity of cyt c in the early stages of apoptosis and a later effect related to its competition in cyt c-Apaf-1 binding interaction in the cytosol.…”
Section: Discussionmentioning
confidence: 67%
“…Thus, the capability of minocycline to affect the peroxidase activity of cyt c may be proposed as a biochemical mechanism involved along with other factors and in combination with other mechanisms, in its neuroprotective effect. [25][26][27].…”
Section: Induction and Inhibition Of Peroxidase Activitymentioning
confidence: 99%
“…Support for this new application of a time-tested antibiotic comes from observations that minocycline readily crosses the blood-brain barrier to the greatest extent of all of the tetracyclines and is well tolerated. It affords neuroprotection in experimental models of Parkinson's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), and acute inflammation after brain trauma or cerebral ischemia [1,3]. Although there are inconsistent reports that show detrimental effects in different models of neurodegeneration [4,5], numerous studies have focused on the mechanisms underlying minocycline-mediated cell protection.…”
Section: Introductionmentioning
confidence: 99%
“…Neuroprotective effect of minocycline may be attributable to its antiapoptotic, antioxidative and anti-inflammatory actions [18,22]. In the experimental models of intracerebral haemorrhage models minocycline was shown to inhibit some inflammatory-related genes [42] as well as microglial/macrophage activation in peri-infarct region [43].…”
Section: Discussionmentioning
confidence: 99%