Minimally Invasive Treatment of the Nasal Inverted Papilloma

Llorente, José Luís; Deleyiannis, Fred; Rodrigo, Juan P.; Núñez, Faustino; Ablanedo, P; Melón, Santiago; Suárez, Carlos

doi:10.1177/194589240301700604

Cited by 31 publications

(24 citation statements)

References 15 publications

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“…Pasquini et al [11] reported lower recurrence rate of 3% with endoscopic procedure and 24% with traditional approaches. Endoscopic approaches have low recurrence rate as also evidenced by other studies [11][12][13]. If inverted papilloma involves inferomedial wall of frontal sinus, modified Lothrop procedure should be done, whereas in cases of lateral or more superior involvement of the frontal sinus, an osteoplastic flap may be additionally needed to gain adequate exposure [7].…”

Section: Discussionmentioning

confidence: 89%

Inverted Papilloma: A Clinico-Pathological Dilemma with Special Reference to Recurrence and Malignant Transformation

Ghosh

Sen

Chandra

et al. 2010

Indian J Otolaryngol Head Neck Surg

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To study the clinicopathological profile, recurrence and malignant potential of the inverted papilloma of nose and paranasal sinuses in relation to the definitive diagnosis and the management undertaken. A total number of 52 cases of histologically proven inverted papilloma managed in our department of otolaryngology over a 10-year period (May 1998-April 2008) were followed up (until October 2009) and the results were analyzed retrospectively to find out any incidence of recurrence of these tumours. A total of 52 inverted papilloma cases were managed with different surgical interventions. Male:female ratio was found to be 10:1. The mean follow up period was 74 months (range 16 months-11 years). Recurrence was observed in 20 (38%) cases. 23% had recurrence without any specific histological pattern, 12% had recurrence with focal dysplasia and 4% had recurrence with malignant transformation into squamous cell carcinoma (SCC). Post-operative radiotherapy was given to 8% (four cases) with malignant transformation. The management of inverted papilloma depends on its size and extension. Recurrence can be minimized by an appropriate surgical planning. Careful endoscopic assessment is essential to detect early recurrence. Recurrent inverted papilloma should be treated more aggressively. Malignant transformation in inverted papilloma should be managed like any aggressive sino-nasal malignancy.

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Section: Discussionmentioning

confidence: 89%

Inverted Papilloma: A Clinico-Pathological Dilemma with Special Reference to Recurrence and Malignant Transformation

Ghosh

Sen

Chandra

et al. 2010

Indian J Otolaryngol Head Neck Surg

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“…Whether traditional open surgical approaches afford any advantage in this respect when compared with modern endoscopic techniques is a subject of controversy. A number of series [3][4][5][6][7] have been reported in the literature in the past 5 years demonstrating the feasibility of endoscopic resection with long-term follow-up. A particularly large series of 160 patients reported by Lawson et al in 2003 [8] demonstrated a low recurrence rate (12%) for endoscopic procedures performed when the inverted papillomas originated from the ethmoid, sphenoid, or medial wall of the maxillary sinus.…”

Section: Surgical Management Of Inverted Papillomamentioning

confidence: 98%

Endoscopic management of inverted papilloma

Lane

Bolger

2006

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Growth in experience with the endoscopic management of inverted papillomas has led to evolving technical improvements and innovations. In most tumor locations, the completeness of resection achieved by a skilled endoscopic surgeon is equivalent, if not superior, to that attained with an open approach. In some instances, an endoscopic exploration with tumor resection may help define the site of tumor attachment and direct adjunctive open procedures when indicated. Long-term outcomes studies with sizeable patient cohorts will be needed to define the role of various surgical strategies in the optimal management of inverted papilloma.

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“…There is little consensus regarding the incidence or role of Epstein-Barr virus (EBV) in IP [119, 120] which is further questioned by other studies [121, 122]. Human papilloma virus (HPV) infection is responsible for 15 to 35 percent of head and neck cancers worldwide [123–130].…”

Section: Etiology and Pathogenesismentioning

confidence: 99%

“…Significant association has been identified between the presence of human papilloma virus DNA in inverted papilloma and recurrence after surgical excision [144, 147, 148]. Some authors argued against the role of HPV in the pathogenesis of exophytic papilloma while others denied its association with developing malignancy and recurrence [121, 149–151]. HPV serotypes 6 and 11 are associated with the fungiform papilloma, and to a lesser degree, with inverted papillomas [37, 120, 152–156].…”

Section: Etiology and Pathogenesismentioning

confidence: 99%

Skull Base Inverted Papilloma: A Comprehensive Review

2012

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Skull base inverted papilloma (IP) is an unusual entity for many neurosurgeons. IP is renowned for its high rate of recurrence, its ability to cause local destruction, and its association with malignancy. This paper is a comprehensive review of the reports, studies, and reviews published in the current biomedical literature from 1947 to September 2010 and synthesize this information to focus on its potential invasion to the base of the skull and possible intradural extension. The objective is to familiarize the clinician with the different aspects of this unusual disease. The role of modern diagnostic tools in medical imaging in order to assess clearly the limits of the tumors and to enhance the efficiency and the safety in the choice of a surgical approach is pointed out. The treatment guidelines for IP have undergone a complex evolution that continues today. Radical excision of the tumour is technically difficult and often incomplete. Successful management of IP requires resection of the affected mucosa which could be achieved with open surgery, endoscopic, or combined approach. Radio and chemotherapy were used for certain indications. More optimally research would be a multicenter randomized trials with large size cohorts.

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Minimally Invasive Treatment of the Nasal Inverted Papilloma

Abstract: According to the literature and our own experience, we believe that the initial surgical management of primary and recurrent inverted papillomas limited to the nasal cavity and paranasal sinuses should be endoscopic sinus surgery.

Cited by 31 publications

References 15 publications

Inverted Papilloma: A Clinico-Pathological Dilemma with Special Reference to Recurrence and Malignant Transformation

Inverted Papilloma: A Clinico-Pathological Dilemma with Special Reference to Recurrence and Malignant Transformation

Endoscopic management of inverted papilloma

Skull Base Inverted Papilloma: A Comprehensive Review

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