Minimally Invasive Ablative Therapies for Definitive Treatment of Localized Prostate Cancer in the Primary Setting

Lee, Eugene W.; Huang, William C.

doi:10.1155/2011/394182

Cited by 3 publications

(1 citation statement)

References 59 publications

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“…According to the above mentioned definition of the International Task Force on Prostate Cancer and the Focal Lesion Paradigm, focal therapy may have a role as local ablative therapies for minimally invasive definitive treatment of localised PC. These treatments are well tolerated with decreased morbidity in association with improvements in technology; however, none of these therapies has enough data available to support their use as an alternative to established therapies (surgery, radiation) for localised PC (3,4). Another potential role of focal therapy could be the management of locally recurrent PC.…”

Section: Introductionmentioning

confidence: 99%

Focal Salvage Therapy for Locally Recurrent Prostate Cancer: A Review

2012

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Objectives: To evaluate the current status of focal therapy as the salvage treatment option for patients with recurrent prostate cancer after established therapy (radiation, surgery) failure for localized tumor. Methods: A MedLine search using specified search terms was done on December 23, 2011. This research rendered 346 papers related to High-Intensity Focused Ultrasound (HIFU), 644 papers related to cryosurgery, 180 related to photodynamic therapy and 3 articles related to radio frequency ablation. Very few of these papers presented original outcome data and are included in the present review. Results: No controlled trial was available for analysis.  Conclusions: Salvage HIFU in patients with local recurrence of prostate cancer after radical EBRT indicate is a reasonable treatment option, but better patient selection criteria are needed. It is a promising treatment option for local recurrence after radiation therapy, with morbidity comparable with other forms of salvage treatment. The side effects are not negligible but comparable with other forms of salvage treatment. Photodynamic therapy is a new option that could be suitable for organ-confined PC recurrence after radiotherapy, but the data are very few.

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Section: Introductionmentioning

confidence: 99%

Focal Salvage Therapy for Locally Recurrent Prostate Cancer: A Review

2012

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Review of the Different Treatments and Management for Prostate Cancer and Fertility

Tran

Boissier

Perrin

et al. 2015

Urology

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Optimization of HIFU monotherapy for prostate cancer

2022

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Introduction. One of the most researched alternative treatments for localized prostate cancer (PCa) is ultrasound ablation (HIFU ¾ High-intensity Focused Ultrasound). Although the world history of the application of this method of PCa treatment is more than 15 years old, the scope of the application of the method has not finally been determined.Purpose of the study. To study the results of the application of ultrasound ablation in the treatment of patients with localized and locally advanced PCa.Materials and methods. The study included 147 patients with PCa who underwent HIFU treatment using the AblathermÒ device («EDAP TMS», Vaulx-en-Velin, Lyon, France). Group 1 included patients with localized and locally advanced PCa treated at the stage of gaining experience and evaluating the results of treatment (n = 82). Group 2 consisted of patients with localized PCa of low and moderate oncological risk (n = 65). The number of sessions in group 1 varied from 1 (65) to 2 (17). The need to perform a second session was associated with the ineffectiveness of the first. HIFU was also performed after the failure of external beam radiation (2), and photodynamic (1) therapy. In group 2, 61 patients received one treatment session, 4 patients received 2 sessions each. The mean follow-up time for the patients in group 1 was 17.4 ± 5.2 (3 – 29) months, for group 2 was 18.2 ± 7.3 (3 – 29) months.Results. In group 1 of patients with a low degree of oncological risk, a decrease in blood prostate-specific antigen (PSA) below the threshold value and the absence of its significant increase during the observation period was noted in 87.5% of cases (28 patients), with an average degree of oncological risk in 65.6% of cases (21 patients), with a high degree in 27.7% of cases (5 patients). In 34.1% (28 patients), the treatment was ineffective, 21 of them underwent repeated ultrasound ablation of the prostate, and 7 patients received subsequent external beam radiation therapy. These results led us to abandon the use of HIFU in patients with baseline blood PSA levels greater than 20 ng/ml and locally advanced disease. In group 2, biochemical recurrence was noted in 9 patients. A control biopsy in 6 patients confirmed local recurrence, which became the basis for a second HIFU session (4). Five patients received adjuvant hormonal therapy. The total effectiveness of the treatment in group 2 was 86.2%.Conclusion. The results support the notion that HIFU is a treatment option for localized PCa only. The evaluation of the initial results led us to abandon treatment with this method in patients with locally advanced and high-risk localized PCa.

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Minimally Invasive Ablative Therapies for Definitive Treatment of Localized Prostate Cancer in the Primary Setting

Cited by 3 publications

References 59 publications

Focal Salvage Therapy for Locally Recurrent Prostate Cancer: A Review

Focal Salvage Therapy for Locally Recurrent Prostate Cancer: A Review

Review of the Different Treatments and Management for Prostate Cancer and Fertility

Optimization of HIFU monotherapy for prostate cancer

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