Mineral Metabolism Disturbances and Arteriovenous Fistula Maturation

Kubiak, Rachel W.; Zelnick, Leila R.; Hoofnagle, Andy; Boer, Ian H. de; Robinson‐Cohen, Cassianne; Kestenbaum, Bryan; Feldman, Harold I.; Dember, Laura M.; Farber, Alik; Kaufman, James M.; Stern, Leonard; Lesage, Pauline; Kivork, C.; Soares, Douglas de Sousa; Malikova, Marina; Allon, Michael; Young, Carlton J.; Taylor, Mark A.; Woodard, L.; Mangadi, K.; Roy‐Chaudhury, Prabir; Munda, Rino; Lee, T.; Alloway, Rita R.; El-Khatib, Mahmoud; Canaan, T.; Pflum, Adam; Thieken, L.; Campos-Naciff, Begona; Huber, Thomas S.; Berceli, Scott A.; Jansen, M.; McCaslin, G.; Trahan, Y.; Vázquez, Miguel A.; Vongpatanasin, Wanpen; Davidson, Ingemar; Hwang, Chin Chang; Lightfoot, T.; Livingston, Charles; Valencia, Ana Lucía; Dolmatch, Bart L.; Fenves, Andrew Z.; Hawkins, Nessa; Cheung, Alfred K.; Kraiss, Larry W.; Kinikini, Daniel V.; Treiman, Gerald S.; Ihnat, Daniel M.; Sarfati, Mark R.; Shiu, Yan-Ting; Terry, Christi M.; Lavasani, Iran; Maloney, Michaella E.; Schlotfeldt, L.; Himmelfarb, Jonathan; Buchanan, Charlotte; Clark, Christopher J.; Crawford, C.; Hamlett, Jane; Kundzins, John; Manahan, L.; Wise, J.; Beck, Gerald J.; Gassman, Jennifer; Greene, Tom; Imrey, Peter B.; Li, L.; Alster, Joan M.; Li, M.; Mackrell, John; Radeva, Milena; Weiss, Brian; Wiggins, Kerri L.; Alpers, Charles E.; Hudkins, Kelly L.; Wietecha, Tomasz; Robbin, Michelle L.; Umphrey, Heidi; Alexander, Lauren; Abts, C.; Belt, L.; Vita, Joseph A.; Hamburg, Naomi M.; Duess, Mai‐Ann; Левит, А Л; Higgins, H. William; Ke, Seiffert; Mandaci, O.; Snell, Christopher R.; Gravley, J.; Behnken, S.; Mortensen, Rikke Nørmark; Chertow, Glenn M.; Besarab, Anatole; Brayman, Kenneth L.; Diener‐West, Marie; Harrison, Donald L.; Inker, Lesley A.; Louis, T.; McClellan, William; Rubin, Jeffrey R.; Kusek, John W.; Star, Robert A.

doi:10.1016/j.ejvs.2019.01.022

Cited by 9 publications

(4 citation statements)

References 36 publications

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“…Without Doppler ultrasound, stenosis leading to AVF failures may be misdiagnosed as thrombosis. Secondly, the impact of mineral metabolism disturbances on AVF maturation remains controversial [ 44 , 45 ]. Despite this, the potential association between the measurable markers of mineral metabolism and functional AVF maturation was not examined in this study.…”

Section: Discussionmentioning

confidence: 99%

Arteriovenous fistula creation by nephrologist and its outcomes: a prospective cohort study from Vietnam

et al. 2023

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Background Arteriovenous fistula (AVF) is the gold standard vascular access for effective hemodialysis. There is a growing interest in AVF creations performed by nephrologists to help reduce vascular surgeons’ workload and enhance the timely treatment of patients with end-stage renal disease (ESRD). However, little is known about the feasibility and effectiveness of this approach in the low-resource settings. We examined the AVF surgical success and failure rates and associated predictors as well as early complications of AVF creations by a trained nephrologist with supports from vascular surgeons in Vietnam. Methods A prospective cohort study was conducted on all adult ESRD patients at the Hemodialysis Department of Thong Nhat Hospital between April 2018 and October 2020. Information on demographic characteristics, comorbidities, and AVF creations was collected using a standardized questionnaire. All patients were followed up until 18 weeks post-surgery. Results Among 100 patients with a mean age of 61.22 ± 17.11 years old, male accounted for 54%. Common causes of ESRD included hypertension (57%) and diabetes (32%). Just more than half (52%) of them reported having an AVF creation prior to ESRD. The successful first-time AVF creation rate was 98% (13/99, 95%CI: 8.74–21.18%). The primary and secondary AVF failure rates were 13.13% (13/99, 95%CI: 8.74–21.18%) and 16.87% (14/83, 95%CI: 10.32–26.25%), respectively. Early complications included bleeding (1%) and early thrombosis of the anastomosis (2%). There was a statistically significant association between age and primary AVF failure (P = 0.005) and between operation time and secondary AVF failure (P = 0.038). Conclusions AVF creations performed by well-trained and skilled interventional nephrologists with supports from vascular surgeons can result in favorable short- and long-term outcomes. It is important to follow up older patients and those with a long operation time to detect AVF failures. A standardized AVF creation training program and practice for nephrologists is needed to increase successful rates.

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Section: Discussionmentioning

confidence: 99%

Arteriovenous fistula creation by nephrologist and its outcomes: a prospective cohort study from Vietnam

et al. 2023

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“…25(OH)D fundamentally helps maintain human skeleton [ 19 ]. As suggested by existing studies, the repair process of ONFH is similar to the mechanism of microfracture repair, which is a high rate of the bone turnover process [ 22 ]. As reported from this study, the non-collapsed group t-P1NP and β-CTx were significantly higher than the collapsed group.…”

Section: Discussionmentioning

confidence: 99%

“…This study found that the non-collapsed group CSI, BSI and ISI were significantly larger than the collapsed group. CSI, constructed from structural engineering principles, measures the maximum compressing load that the femoral neck could withstand per unit thickness cross-sectional slice and the unit of normal compression load exerted on the femoral neck [ 22 ]. As indicated by the calculation formulas of CSI, BSI and ISI, when BMD, weight and height are identical, the larger the FNW, the larger CSI, BSI and ISI will be [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Composite indices of femoral neck strength predicts the collapse of steroid-associated osteonecrosis of the femoral head: a retrospective study

Lin

Cai

Yang³

et al. 2022

BMC Musculoskelet Disord

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Purposes The purpose of this study was to investigate the predictive effect exerted by composite indices of femoral neck strength (compressive strength index (CSI), bending strength index (BSI) and impact strength index (ISI) on the femoral head collapse in steroid-associated ONFH patients. Methods Nonoperative steroid-associated osteonecrosis of the femoral head (ONFH) patients from 2017 to 2019 were selected. The patients fell into the collapsed group and the non-collapsed group according to whether the femoral head collapsed. CSI, BSI and ISI were calculated. Moreover, bone turnover markers were measured. The statistical analysis was conducted on the predictive effects of composite indices of femoral neck strength and bone turnover index on ONFH collapse. Results A total of 62 patients were included. The mean CSI, BSI and ISI were significantly lower in the collapsed group than those in the non-collapsed group (P < 0.05). CSI, ISI,t-P1NP and β-CTx were suggested as the protective risk factors for the femoral head collapse in ONFH patients. The ISI area under the curve values was 0. 878.The mean survival time of the hips of patients with ISI greater than 0.435 was greater (P < 0.05) than that of patients with ISI less than 0.435. Conclusion The composite indices of femoral neck strength can predict steroid-associated ONFH femoral head collapse more effectively than the bone turnover markers. The ISI value of 0.435 is a potential cut-off value, lower than this value can predict the early collapse of steroid-associated ONFH.

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“…Other vascular calcification markers such as fetuin-A, osteopontin, and bone morphogenetic protein-7 were also associated with the development of AVF complications in a cohort of dialysis patients ( 96 ). However, a prospective clinical study came to the opposite conclusion ( 97 ). The study concluded that serum concentrations of mineral metabolites in patients were not substantially related to AVF failure.…”

Section: Molecular Mechanism Of Arteriovenous Fistula Failurementioning

confidence: 99%

Oxidative stress: An essential factor in the process of arteriovenous fistula failure

Guo

et al. 2022

Front. Cardiovasc. Med.

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For more than half a century, arteriovenous fistula (AVFs) has been recognized as a lifeline for patients requiring hemodialysis (HD). With its higher long-term patency rate and lower probability of complications, AVF is strongly recommended by guidelines in different areas as the first choice for vascular access for HD patients, and its proportion of application is gradually increasing. Despite technological improvements and advances in the standards of postoperative care, many deficiencies are still encountered in the use of AVF related to its high incidence of failure due to unsuccessful maturation to adequately support HD and the development of neointimal hyperplasia (NIH), which narrows the AVF lumen. AVF failure is linked to the activation and migration of vascular cells and the remodeling of the extracellular matrix, where complex interactions between cytokines, adhesion molecules, and inflammatory mediators lead to poor adaptive remodeling. Oxidative stress also plays a vital role in AVF failure, and a growing amount of data suggest a link between AVF failure and oxidative stress. In this review, we summarize the present understanding of the pathophysiology of AVF failure. Furthermore, we focus on the relation between oxidative stress and AVF dysfunction. Finally, we discuss potential therapies for addressing AVF failure based on targeting oxidative stress.

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Mineral Metabolism Disturbances and Arteriovenous Fistula Maturation

Cited by 9 publications

References 36 publications

Arteriovenous fistula creation by nephrologist and its outcomes: a prospective cohort study from Vietnam

Arteriovenous fistula creation by nephrologist and its outcomes: a prospective cohort study from Vietnam

Composite indices of femoral neck strength predicts the collapse of steroid-associated osteonecrosis of the femoral head: a retrospective study

Oxidative stress: An essential factor in the process of arteriovenous fistula failure

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