Mineral evolution of bone

Ravaglioli, A.; Krajewski, A.; Celotti, G.; Piancastelli, Andreana; Bacchini, B.; Montanari, Luciano; Zama, G.; Piombi, L.

doi:10.1016/0142-9612(96)88712-6

Cited by 85 publications

(55 citation statements)

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“…This is only partly consistent with tooth eruption data from the same study (Hopkins et al 2007), showing that BL × M and PD g × BLM, but not PD m × M, lambs showed earlier eruption of permanent dentition. In agreement with this discrepancy, bone magnesium content of PD m × M lambs at earlier timepoints was also consistent with the mineral profile of physiologically less mature animals, despite their more relatively advanced skeletal maturity (Ravaglioli et al 1996;Cake et al 2006b). Similarly, although ewes are known to mature earlier in terms of metacarpal growth plate closure (Ho et al 1989;Jeremiah et al 1997) and were clearly demonstrated in this study to be earlier maturing skeletally, the absence of a gender difference in bone magnesium content and the later eruption of permanent dentition in ewes shown by Hopkins et al (2007) suggests this does not necessarily reflect earlier physiological maturation.…”

Section: Discussionsupporting

confidence: 66%

“…Bone ash calcium, phosphorus and magnesium content were determined to assess the 'mineral maturity' of bone (Grynpas 1993;Ravaglioli et al 1996;Cake et al 2006b). …”

Section: Mineral Analysismentioning

confidence: 99%

“…However, it is not clear to what extent alternative, qualitative maturity indices such as physeal closure or dental eruption accurately reflect physiological or even skeletal maturation. An alternative index of maturity may be bone mineral profile, in particular magnesium content which steadily declines in a manner which appears to reflect physiological rather than chronological age (Ho et al 1989;Ravaglioli et al 1996;Cake et al 2006b). …”

Section: Introductionmentioning

confidence: 99%

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Genotype and gender effects on sheep limb bone growth and maturation: selection for loin depth causes bone hypotrophy

Cake

Boyce

Gardner

et al. 2007

Aust. J. Exp. Agric.

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This study aimed to compare limb bone growth between offspring of typical crosses used in Australian prime lamb production. Limb bones from sheep of five genotypes – Merino (M × M), Border Leicester sire × Merino (BL × M), Poll Dorset sires selected for growth × Merino (PDg × M), Poll Dorset sires selected for eye muscle depth (PDm × M) × Merino, or second cross (PDg × BLM) – at four time points from 4 to 22 months of age (n = 593) were dissected, measured and weighed. Growth curves were fitted within genotype groups and used to compare (i) overall limb bone growth in terms of length and weight, (ii) differences in allometric growth coefficients for individual bones, (iii) relative limb bone proportions, and (iv) maturity proportion. Results showed two distinct phenotypes in terms of limb bone growth: (i) relative bone hypotrophy of lambs from PDm × M, suggesting that selection for loin depth (PEMD EBV) may be linked with smaller limb size and that their higher muscle : bone ratio may be due to a relative decrease in bone rather than increase muscle weight; and (ii) Merinos were found to have comparable limb length to terminal sire crosses, although distal limb elements were proportionately longer at the expense of the proximal segments that are associated larger muscles. There was a general lack of major differences in bone growth between sheep very different in other production traits, particularly when compared allometrically. Thus, differences in bone growth, proportion or skeletal maturation were greater between ewes and wethers than between these divergent genotypes. PDm × M and BL × M were found to be earlier maturing in terms of limb length, although the bone mineral profile (magnesium content) of PDm × M was suggestive of relative physiological immaturity.

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Section: Discussionsupporting

confidence: 66%

“…Bone ash calcium, phosphorus and magnesium content were determined to assess the 'mineral maturity' of bone (Grynpas 1993;Ravaglioli et al 1996;Cake et al 2006b). …”

Section: Mineral Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genotype and gender effects on sheep limb bone growth and maturation: selection for loin depth causes bone hypotrophy

Cake

Boyce

Gardner

et al. 2007

Aust. J. Exp. Agric.

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“…Sheep have a predominance of plexiform bone until 3 to 4 years of age (Newman et al 1995) due to fast growth in weight and size (Reinwald and Burr 2011) and just a predominance of secondary Haversian systems after 7 to 9 years of age with the presence of bone remodelling (Newman et al 1995). Sheep also presents a trabecular bone density, mineralization and subsequently elevated strength relative to humans, that are variable according to skeletal location (Nafei et al 2000, Liebschner 2004), nevertheless the bone mineral composition being apparently similar between small ruminants and humans (Ravaglioli et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Bone turnover markers in sheep and goat: A review of the scientific literature

Camassa

Diogo

Sousa

et al. 2017

An. Acad. Bras. Ciênc.

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Bone turnover markers (BTMs) are product of bone cell activity and are generally divided in bone formation and bone resorption markers. The purpose of this review was to structure the available information on the use of BTMs in studies on small ruminants, especially for monitoring their variations related to diet, exercise, gestation and metabolic lactation state, circadian and seasonal variations, and also during skeletal growth. Pre-clinical and translational studies using BTMs with sheep and goats as animal models in orthopaedic research studies to help in the evaluation of the fracture healing process and osteoporosis research are also described in this review. The available information from the reviewed studies was systematically organized in order to highlight the most promising BTMs in small ruminant research, as well as provide a wide view of the use of sheep and goat as animal models in orthopaedic research, type of markers and commercial assay kits with cross-reactivity in sheep and goat, method of sample and storage of serum and urine for bone turnover markers determination and the usefulness and limitations of bone turnover markers in the different studies, therefore an effective tool for researchers that seek answers to different questions while using BTMs in small ruminants.

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“…Numerous animal models have been described and utilized in literature. These included: pig, dog, sheep, goat, rat, guinea pig, chicken, and mice [2][3][4][5][6][7]. These animal models differ with respect to: anatomical limitations, biologic acceptability of certain materials, availability of the animals, and ethical considerations.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Various Positions on the Ovine Pelvis for Dental Implant Research

Kloppers¹

2016

IJDOS

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Aims: An ex vivo and in vivo study to determine various positions in the ovine pelvis to evaluate dental implant placement. Settings and Design:• A novel, unique surgical dissection was described as the caudal roll-up technique and was utilized to obtain maximal exposure to the Linea Glutea, with the least morbidity.• Insertion torque (IT) of osseo-integrated dental implants was measured at predetermined positions described as A-F along the ovine linea glutea.• The amount of outer cortical bone was measured at predetermined sections A-F on harvested ovine pelvi, to coincide with the implant positions as placed. Statistical analysis used: Descriptive Study.Intraoral dental implant research in animals is challenging, owing in particular to different tooth morphology. One of the most challenging problems with intraoral implant research in animals is an infection form contaminated oral cavity, which is evident in intraoral research related to pigs and dogs [8]. Intraoral dental implant studies by Vlaminck confirmed that the specific oral biomechanics inherent to a sheep's constant ruminant activity accounted for high degrees of implant failures [13,25]. A novel, unique surgical dissection was described as the caudal roll-up technique and was utilized to obtain maximal exposure to the Linea Glutea, with the least morbidity. Data collected concerning the insertion torque of implants placed and the cortical thickness measurements of the sheep's ilia was discussed.

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Mineral evolution of bone

Cited by 85 publications

References 1 publication

Genotype and gender effects on sheep limb bone growth and maturation: selection for loin depth causes bone hypotrophy

Genotype and gender effects on sheep limb bone growth and maturation: selection for loin depth causes bone hypotrophy

Bone turnover markers in sheep and goat: A review of the scientific literature

Evaluation of Various Positions on the Ovine Pelvis for Dental Implant Research

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