Miliaria and anhidrosis. 3. Multiple small patches and the effects of different periods of occlusion

Sulzberger, Marion B.

doi:10.1001/archderm.105.6.845

Cited by 10 publications

(8 citation statements)

References 14 publications

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“…Parakeratotic plugs surely do offer an obstruction to the flow of sweat, probably explaining the anhidrosis in chronic dermatoses and after intense acute injury, viz., freezing, ultra-violet radiation, etc. In their recent investigation, Sulzberger & Harris (1972) could find no keratotic plugs nor any other kind of a block. Curiously we have had no difficulty in visualizing the formation of an anatomical obstruction.…”

Section: Discussionmentioning

confidence: 95%

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The pathogenesis of miliaria rubra.

Hölzle

Kligman

1978

Br J Dermatol

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Anhidrosis was induced in volunteers by covering the skin with an impermeable plastic film. The degree of sweat suppression and miliaria after a thermal stimulus was directly proportional to the increase in the density of resident aerobic bacteria, notably cocci. No anhidrosis resulted when antibacterial substances were used to prevent the expansion of the microflora. Histological study showed a PAS-positive diastase resistant amorphous mass deep within the acrosyringium after 2 days of occlusion, accompanied by a periductal dermal infiltration of leukocytes. After another 2 days the duct became clogged by an amalgam of degenerating leukocytes. This impaction sloughed after about 3 weeks as a result of epidermal renewal. Colonies of bacteria were never found within the ducts. It is postulated that cocci secrete a toxin which injures luminal cells and precipitates a cast within the lumen. Infiltration by leukocytes creates an impaction which completely obstructs the passage of sweat for several weeks.

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Section: Discussionmentioning

confidence: 95%

“…In still another study, Sulzberger & Harris (1972) wished to find out what the earliest anatomical changes were in their occlusion model. They carefully examined histological sections after various periods of occlusion.…”

Section: Historical Reviewmentioning

confidence: 99%

The pathogenesis of miliaria rubra.

Hölzle

Kligman

1978

Br J Dermatol

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“…Agner & Serup (16) tudied kin reaction after clo ed patche and showed tran ient water damage as demonstrated by increased transepidermal water loss after occlusion for 24 h. However, the irritancy of water under occlusion can result from water per se or from retention of sweat, which is more irritant than the water per se (17). Notwithstanding, after prolonged occlusion, anhidrosis results (18)(19)(20). Occlusion modifies reactive events in Langerhans cells (21,22), and has a profound effect on cytokine production (23).…”

Section: Accepted For Publication 2 June 1999mentioning

confidence: 99%

How irritant is water? An overview

1999

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Water is a skin irritant which deserves attention because of its ubiqujty. During the Vietnam war, soldiers suffered from painful swollen feet, so-called tropical immersion foot. In occupational dermatology, the importance of water as a skin irritant is especially appreciated. The irritancy of water has been demonstrated by occlusion experiments; occlusion with either closed chambers or water-soaked patches has been shown to produce clinical and histopathological inflammation . Functional damage, as revealed by increased transepidermal water loss, bas also been shown. Repeated water exposure without occlusion caused an increase in blood flow on irritated skin; however, clinical evaluation did not show a difference in dryness or scaling. Several mechanisms such as osmolarity, pH, hardness and temperature might account for the irritancy of water. Extraction or dilution of natural moisturizing factors in the stratum corneum is another po sible explanation. Occlusion per se also changes the physiology of skin and may trigger the activation of potentially active substances. However, much remains to be done to clarify the risk factors and mechanisms of water-induced irritation .

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“…The parakeratotic plug forms as a reparative process in this case, with the resultant histologically visible anatomic obstruction perpetuating the miliaria. A later study confirmed the early absence of plugs in experimentally induced miliaria after various periods of occlusion (20). Instead, only pedductal inflammation was seen in 1200 serial sections.…”

Section: Discussionmentioning

confidence: 99%

Congenital Miliaria Crystallina: Case Report and Literature Review

Arpey¹,

Nagashima-Whalen²,

Chren

et al. 1992

Pediatric Dermatology

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Generalized congenital miliaria crystallina occurred in a black newborn boy. Although miliaria crystallina occurring in infancy and beyond is well established, congenital occurrence is very rare. The pathogenesis of the disorder is not well understood. We discuss some hypotheses of pathogenesis in the context of our patient, as well as a differential diagnosis and a comparison with a previously reported case. Miliaria crystallina should be considered in the differential diagnosis of vesiculobullous eruptions in newborns.

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Miliaria and anhidrosis. 3. Multiple small patches and the effects of different periods of occlusion

Cited by 10 publications

References 14 publications

The pathogenesis of miliaria rubra.

The pathogenesis of miliaria rubra.

How irritant is water? An overview

Congenital Miliaria Crystallina: Case Report and Literature Review

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