Mild Tremor in Relatives of Patients With Essential Tremor

Abstract

A considerable number of seemingly normal case relatives may have a genetic predisposition for tremor. Even among older case relatives (> or =60 years of age), there was an increased prevalence of higher tremor scores, suggesting that in that age group, subclinical ET may be present and penetrance still may not be complete.

‘Essential Tremor' or ‘the Essential Tremors': Is This One Disease or a Family of Diseases?

“…Furthermore, when other disorders (e.g., AD, PD) occur at or after the age of 65, one does not refer to them as “senile dementia” or “senile parkinsonism”. The notion that ET must occur prior to the age of 65 is unfounded; indeed, it has been demonstrated in familial forms of the disorder that penetrance is not even complete by age 65 [52]. The term “senile tremor” is an arcane term that was used early in the last century, and it is not a particularly useful construct today.…”

‘Essential Tremor' or ‘the Essential Tremors': Is This One Disease or a Family of Diseases?

“…Furthermore, when other disorders (e.g., AD, PD) occur at or after the age of 65, one does not refer to them as “senile dementia” or “senile parkinsonism”. The notion that ET must occur prior to the age of 65 is unfounded; indeed, it has been demonstrated in familial forms of the disorder that penetrance is not even complete by age 65 [52]. The term “senile tremor” is an arcane term that was used early in the last century, and it is not a particularly useful construct today.…”

Reference Values of the Forearm Tremor Power Spectra for Youth Athletes

“…The results of our study confirm those findings. However, reports on the logarithmic nature of tremor size had appeared even earlier ( Louis et al, 2001 ; Viitasalo and Gajewski, 1994 ). Our results provide evidence that tremor amplitude or power is log-normally distributed among the population.…”

Comparative Burden of Subclinical Tremor in a Cohort of Normal Individuals Stratified by Familial Risk for Essential Tremor

“…We previously conducted studies with different designs assessing mild tremor in ET families. ET cases and controls were enrolled in a family study [10]. Their first- and second-degree relatives underwent a videotaped tremor examination.…”

“…Data were analyzed on 201 case relatives and 212 control relatives who did not meet diagnostic criteria for ET [10]. The mean total tremor score of first-degree case relatives was higher than that of first-degree control relatives (p <0.003) and a larger percentage (55.2% vs 36.6%; p = 0.01) of first-degree case relatives had total tremor scores of 4 or more [10]. That study differed from the present study because we did not attempt to estimate the increased odds of mild tremor in relatives of ET cases.…”

‘Essential Tremor' or ‘the Essential Tremors': Is This One Disease or a Family of Diseases?

“…Furthermore, when other disorders (e.g., AD, PD) occur at or after the age of 65, one does not refer to them as “senile dementia” or “senile parkinsonism”. The notion that ET must occur prior to the age of 65 is unfounded; indeed, it has been demonstrated in familial forms of the disorder that penetrance is not even complete by age 65 [52]. The term “senile tremor” is an arcane term that was used early in the last century, and it is not a particularly useful construct today.…”

Reference Values of the Forearm Tremor Power Spectra for Youth Athletes

“…The results of our study confirm those findings. However, reports on the logarithmic nature of tremor size had appeared even earlier ( Louis et al, 2001 ; Viitasalo and Gajewski, 1994 ). Our results provide evidence that tremor amplitude or power is log-normally distributed among the population.…”

Comparative Burden of Subclinical Tremor in a Cohort of Normal Individuals Stratified by Familial Risk for Essential Tremor

“…We previously conducted studies with different designs assessing mild tremor in ET families. ET cases and controls were enrolled in a family study [10]. Their first- and second-degree relatives underwent a videotaped tremor examination.…”

“…Data were analyzed on 201 case relatives and 212 control relatives who did not meet diagnostic criteria for ET [10]. The mean total tremor score of first-degree case relatives was higher than that of first-degree control relatives (p <0.003) and a larger percentage (55.2% vs 36.6%; p = 0.01) of first-degree case relatives had total tremor scores of 4 or more [10]. That study differed from the present study because we did not attempt to estimate the increased odds of mild tremor in relatives of ET cases.…”

‘Essential Tremor' or ‘the Essential Tremors': Is This One Disease or a Family of Diseases?

“…Furthermore, when other disorders (e.g., AD, PD) occur at or after the age of 65, one does not refer to them as “senile dementia” or “senile parkinsonism”. The notion that ET must occur prior to the age of 65 is unfounded; indeed, it has been demonstrated in familial forms of the disorder that penetrance is not even complete by age 65 [52]. The term “senile tremor” is an arcane term that was used early in the last century, and it is not a particularly useful construct today.…”

Reference Values of the Forearm Tremor Power Spectra for Youth Athletes

“…The results of our study confirm those findings. However, reports on the logarithmic nature of tremor size had appeared even earlier ( Louis et al, 2001 ; Viitasalo and Gajewski, 1994 ). Our results provide evidence that tremor amplitude or power is log-normally distributed among the population.…”

Comparative Burden of Subclinical Tremor in a Cohort of Normal Individuals Stratified by Familial Risk for Essential Tremor

“…We previously conducted studies with different designs assessing mild tremor in ET families. ET cases and controls were enrolled in a family study [10]. Their first- and second-degree relatives underwent a videotaped tremor examination.…”

“…Data were analyzed on 201 case relatives and 212 control relatives who did not meet diagnostic criteria for ET [10]. The mean total tremor score of first-degree case relatives was higher than that of first-degree control relatives (p <0.003) and a larger percentage (55.2% vs 36.6%; p = 0.01) of first-degree case relatives had total tremor scores of 4 or more [10]. That study differed from the present study because we did not attempt to estimate the increased odds of mild tremor in relatives of ET cases.…”