Mild Infantile Hypercalcemia: Diagnostic Tests and Outcomes

Development of paediatric biochemistry centile charts as a complement to laboratory reference intervals

“…16 A second phase of avid bone accretion is seen during the pubertal growth spurt. 18 In the study, only one reference interval was used for the entire cohort of infants (0.25-24 months) and it was considerably lower than those published elsewhere. A further decrease in the concentration of both after puberty correlates with the decrease in bone activity.…”

Genetic Defect inCYP24A1, the Vitamin D 24-Hydroxylase Gene, in a Patient with Severe Infantile Hypercalcemia

“…Our replication cohort consisted of an additional 27 children who presented to a pediatric calcium disorder specialty clinic with infantile hypercalcemia (8). Laboratory characteristics of those patients are described in Supplemental Table 1, published on The Endocrine Society's Journals Online web site at http:// jcem.endojournals.org.…”

Transient Hypercalcemia in Preterm Infants

“…The specific cause of infantile hypercalcemia could not be made in slightly higher than two thirds of the cases, leading to the diagnosis of idiopathic infantile hypercalcemia. 6 The cause of this diagnosis of exclusion remains unknown, although it has been associated with an increased intestinal ability to absorb calcium, suggesting the possibility of hypersensitivity to vitamin D. 3 …”