Mild hyperhomocysteinemia promotes renal hemodynamic dysfunction without histopathologic changes in adult rats

Ossani, Georgina Paula; Fischer, Patricia; Caram, Silvia G.; Dominguez, Graciela N.; Monserrat, Alberto J.; Masnatta, Lucas

doi:10.1111/j.1523-1755.2004.00960.x

Cited by 7 publications

(7 citation statements)

References 40 publications

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“…dl ‐Homocysteine thiolactone is water soluble and is converted to homocysteine by hydrolysis, increasing plasma homocysteine levels 22,26,27 . The dose of DL‐HT administered to rats in the present study was based on average daily water intake.…”

Section: Methodsmentioning

confidence: 99%

“…The hypothesis that HHcys may increase blood pressure can be tested experimentally by feeding dl ‐homocysteine thiolactone (DL‐HT) to laboratory animals and studying its cardiovascular effects. Hyperhomocysteinaemia is assumed when the homocysteine concentration is higher than 12 µmol/L, being divided approximately into mild (< 30 µmol/L), moderate (30–100 µmol/L) or severe (> 100 µmol/L) HHcys 21–23 …”

Section: Introductionmentioning

confidence: 99%

“…Hyperhomocysteinaemia is assumed when the homocysteine concentration is higher than 12 mmol/L, being divided approximately into mild (< 30 mmol/L), moderate (30-100 mmol/L) or severe (> 100 mmol/L) HHcys. [21][22][23] Assuming that HHcys evokes cardiovascular changes, we attempted to verify the effect of moderate HHcys, induced by the treatment of rats with DL-HT for 15 days, on blood pressure, heart rate, baroreflex and vascular reactivity. To further test cause, cardiovascular effects were also investigated after DL-HT washout to…”

Section: Introductionmentioning

confidence: 99%

“…The third group consisted of untreated animals (control group).dl-Homocysteine thiolactone is water soluble and is converted to homocysteine by hydrolysis, increasing plasma homocysteine levels. 22,26,27 The dose of DL-HT administered to rats in the present study was based on average daily water intake. Control, HHcys and HHcys-W rats were housed separately and fed standard rat food.…”

mentioning

confidence: 99%

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Hyperhomocysteinaemia‐induced Cardiovascular Changes in Rats

Resstel¹,

Andrade²,

Haddad

et al. 2008

Clin Exp Pharma Physio

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(1) Increased plasma homocysteine content and increased blood pressure are independently associated with higher cardiovascular risks. The present study was designed to determine the effects of hyperhomocysteinaemia (HHcys) on the activity of the cardiovascular system in rats. (2) Using male Wistar rats, the effect of moderate HHcys, induced by treating rats with dl-homocysteine thiolactone (DL-HT; 1 g/kg per day) for 15 days, on arterial blood pressure, heart rate, baroreflex and vascular reactivity was determined. (3) Hyperhomocysteinaemia was observed after 15 days of treatment. Baseline arterial blood pressure and heart rate values of HHcys animals were significantly increased after 15 days of treatment. Plasma homocysteine and cardiovascular parameters returned to control values after termination of treatment. Baroreflex gain was significantly enhanced in HHcys rats. The pressor effect of an i.v. infusion of phenylephrine (50 mg/kg per mL) was decreased in HHcys rats and returned to control values after washout of DL-HT. Hypotensive responses to i.v. infusions of sodium nitroprusside (70 mg/kg per mL) or acetylcholine (10 mg/kg per mL) were increased in HHcys animals and returned to control values after washout of DL-HT. The increase in resting arterial blood pressure associated with the moderate HHcys was reversed by treatment with the b1-adrenoceptor antagonist atenolol, suggesting that HHcys-related hypertension is related to increase in cardiac sympathetic activity. (4) The present study showed significantly increased arterial blood pressure, heart rate and baroreflex activity in the early phase of moderate HHcys. In addition, HHcys was associated with alterations of vascular responsiveness to pressor and depressor agents, as well as increased cardiac sympathetic activity. The fact that cardiovascular changes observed in HHcys were reversed after DL-HT washout indicate that moderate HHcys evokes cardiovascular changes.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Hyperhomocysteinaemia‐induced Cardiovascular Changes in Rats

Resstel¹,

Andrade²,

Haddad

et al. 2008

Clin Exp Pharma Physio

View full text Add to dashboard Cite

show abstract

“…It is fairly well established that hyperhomocysteinemia may alter renal hemodynamics in experimental models [20]. Studies in humans are more controversial.…”

Section: Homocysteinementioning

confidence: 99%