Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation

Jiang, Dong; Jiang, Zheng; Lü, Di; Wang, Xuan; Liang, Haisha; Zhang, Junfeng; Meng, Yahui; Liu, Ying; Wu, Danni; Huang, Yuwei; Chen, Yuling; Deng, Haiteng; Wu, Qing; Xiong, Jing-Wei; Meng, Anming; Yu, Li

doi:10.1038/s41556-019-0358-6

Cited by 166 publications

(214 citation statements)

References 22 publications

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“…Recently, migrasomes have been shown to play an important role in zebrafish organ morphogenesis by releasing chemokine signals to defined regions of the embryo. 2 Thus, migracytosis is considered as a major mechanism for migrasomes to carry out their functions. It has been frequently observed that intact migrasomes can be engulfed by surrounding cells, 1 and this has been proposed as a potential mechanism for lateral transfer of cellular contents between cells.…”

Section: Dear Editormentioning

confidence: 99%

Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells

et al. 2020

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Section: Dear Editormentioning

confidence: 99%

Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells

et al. 2020

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“…In zebrafish embryos, generation of migrasomes has been observed during gastrulation. Migrasomes were shown to be essential for organ morphogenesis during embryonic development 3 . We thus tested the inhibitory effect of SAR407899 on migrasome biogenesis in a zebrafish model.…”

Section: O R R E S P O N D E N C E O P E N a C C E S Smentioning

confidence: 99%

“…1f, g). It was reported that migrasomes formation in zebrafish embryos ensure the Kupffer's vesicle (KV) formation which is essential in establishing the left-right body axis 3 . We found that treatment with SAR407899 indeed significantly impaired KV formation with smaller area and fewer cilia ( Fig.…”

Section: O R R E S P O N D E N C E O P E N a C C E S Smentioning

confidence: 99%

Chemical screening identifies ROCK1 as a regulator of migrasome formation

Lü

et al. 2020

Cell Discov

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“…3E), discovered in 2015, are exosome-like pockets emerging from nanotubular networks formed during cell migration in vitro. It was observed that lengthy, branched, plasma membrane-connected lipid nanotubes attached to exosome-like vesicles, altogether termed the migrasome, appear at the rear end of migrating cells [49,67,76,77]. So far, the function of migrasomes has been proposed to be facilitating cell-to-cell communication.…”

Section: Cytonemes (Insects)mentioning

confidence: 99%

“…Migrasomes have been also shown to be essential for organ morphogenesis during the embryonic development of zebra fish [77]. During this process, migrasomes release ligands and proteins at defined locations of embryos to induce formation of organs.…”

Section: Cytonemes (Insects)mentioning

confidence: 99%

Biological lipid nanotubes and their potential role in evolution

Gözen

Dommersnes

2020

Eur. Phys. J. Spec. Top.

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The membrane of cells and organelles are highly deformable fluid interfaces, and can take on a multitude of shapes. One distinctive and particularly interesting property of biological membranes is their ability to from long and uniform nanotubes. These nanoconduits are surprisingly omnipresent in all domains of life, from archaea, bacteria, to plants and mammals. Some of these tubes have been known for a century, while others were only recently discovered. Their designations are different in different branches of biology, e.g. they are called stromule in plants and tunneling nanotubes in mammals. The mechanical transformation of flat membranes to tubes involves typically a combination of membrane anchoring and external forces, leading to a pulling action that results in very rapid membrane nanotube formation – micrometer long tubes can form in a matter of seconds. Their radius is set by a mechanical balance of tension and bending forces. There also exists a large class of membrane nanotubes that form due to curvature inducing molecules. It seems plausible that nanotube formation and functionality in plants and animals may have been inherited from their bacterial ancestors during endosymbiotic evolution. Here we attempt to connect observations of nanotubes in different branches of biology, and outline their similarities and differences with the aim of providing a perspective on their joint functions and evolutionary origin.

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Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation

Cited by 166 publications

References 22 publications

Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells

Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells

Chemical screening identifies ROCK1 as a regulator of migrasome formation

Biological lipid nanotubes and their potential role in evolution

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