Migraine with Aura: Surface-Based Analysis of the Cerebral Cortex with Magnetic Resonance Imaging

Petrušić, Igor; Daković, Marko; Kačar, Katarina; Zidverc-Trajković, Jasna

doi:10.3348/kjr.2018.19.4.767

Cited by 31 publications

(60 citation statements)

References 31 publications

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“…Migraine is a heterogeneous neurological disease. Some datasets only enrolled episodic migraineurs [12,15,16,22,[24][25][26]28], while some other datasets included both episodic and chronic migraineurs [13,14] or only chronic migraineurs [11,44]. Majority of the datasets (n = 14) in the CBMA included patients with mixed gender [10, 11, 13-17, 22, 25-28, 44], while two datasets only included female migraine patients [23,24] and one only male migraine patients [12].…”

Section: Discussionmentioning

confidence: 99%

“…Majority of the datasets (n = 14) in the CBMA included patients with mixed gender [10, 11, 13-17, 22, 25-28, 44], while two datasets only included female migraine patients [23,24] and one only male migraine patients [12]. Some datasets only included patients with aura [16,23,25,28] or without aura [13,22,[24][25][26], while some other studies included both patients with migraine without aura and with aura [10,11,15,17]. Individual CTh studies showed that the observed regional pattern of CTh abnormalities in patients with migraine was in uenced by age [10,11], gender [12], gender [12], disease duration [11, [13][14][15], attack frequency [13][14][15]44], pain intensity [14], the presence of aura [15][16][17], and photosensitivity [18].…”

Section: Discussionmentioning

confidence: 99%

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Cortical thickness in migraine: a coordinate-based meta-analysis

Sheng

Shi³

et al. 2020

Preprint

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Background Cortical thickness (CTh) analysis is a popular method to characterize brain morphometry. Many studies have been performed to investigate CTh abnormalities in migraine. However, the results from these studies were not consistent and even conflicting. These divergent results hinder us from obtaining a clear picture of brain morphometry regarding CTh alterations in migraine. Coordinate-based meta-analysis (CBMA) is a promising technique to quantitatively pool individual neuroimaging studies to identify consistent brain areas involved. Methods Electronic databases (PubMed, Embase, Web of Science, China National Knowledge Infrastructure, WanFang, and SinoMed) and other sources (bioRxiv and reference lists of relevant articles and reviews) were systematically searched for studies that compared regional CTh differences between patients with migraine and healthy controls (HCs) up to May 15, 2020. A CBMA was performed using the Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) approach. Results In total, we identified 16 studies with 17 datasets reported that were eligible for the CBMA. The 17 datasets included 872 patients with migraine (average sample size 51.3, mean age 39.6 years, 721 females) and 949 HCs (average sample size 59.3, mean age 44.2 years, 680 females). The CBMA detected no statistically significant consistency of CTh alterations in patients with migraine relative to HCs. Sensitivity analysis and subgroup analysis verified this result to be robust. Meta-regression analyses revealed that this CBMA result was not confounded by age, gender, aura, attack frequency per month, and illness duration. Conclusions Our CBMA adds to the evidence of the replication crisis in neuroimaging research that is increasingly recognized. The current evidence suggests that CTh is not a reliable biomarker of migraine. Many potential confounders, such as underpowered sample size, heterogeneous patient selection criteria, and differences in imaging collection and methodology, may contribute to the inconsistencies of CTh alterations in migraine, which merit attention before planning future research on this topic.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cortical thickness in migraine: a coordinate-based meta-analysis

Sheng

Shi³

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…In about one‐third of patients with migraine, a headache is accompanied or preceded by an aura . More than 90% of patients with migraine with auras have visual auras . Visual and ophthalmologic signs and symptoms are commonly reported by patients with migraine .…”

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confidence: 99%

“…M igraine is a chronic, paroxysmal, neurovascular primary headache that affects approximately 15% of people worldwide. 1,2 Although there are changes in cerebral vascular reactivity in the etiology of migraine, it is controversial. [3][4][5][6][7] There is evidence that systemic and cerebral circulation is affected by migraine.…”

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confidence: 99%

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Evaluation of the Optic Nerve by Strain and Shear Wave Elastography in Patients With Migraine

Şahan

Doğan

İnal

et al. 2018

J of Ultrasound Medicine

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Objectives To investigate the optic nerve's elastic properties using shear wave and strain elastography in patients with migraine compared to healthy individuals. Methods The migraine group consisted of 30 patients (16 with visual auras and 14 without auras) who had previously had a diagnosis of migraine. These were age and sex matched with healthy participants to form the control group. The findings from shear wave and strain elastography in the groups were compared. The elastographic examination was performed with a 6–15‐MHz multifrequency linear array transducer. Results The evaluation involved 30 patients with migraine (3 male and 27 female), whose mean age ± SD was 34.63 ± 10 years, and 30 healthy participants (3 males, 27 females), whose mean age was 36.4 ± 10.5 years. In strain elasticity patterns, a statistically insignificant hardening of the optic nerve in the patients with migraine was observed (P = .052). Analysis of the shear wave elastic modulus values (9.8 ± 3.34 and 12.3 ± 5.25 kPa; P = .03) revealed that differences between the healthy participants and patients with migraine were statistically significant. The results for elasticity patterns and the shear modulus suggested that the differences between migraines with and without visual auras were insignificant (P > .05). A positive correlation was discovered between the duration of the disease and the shear modulus in the patients with migraine (r = 0.496; P < .01). Conclusions Histopathologic changes in the optic nerve may be seen in patients with migraine due to possible fibrotic changes. Elastographic techniques can be useful diagnostic tools for investigating these changes.

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Causal association between systemic lupus erythematosus and the risk of migraine: A Mendelian randomization study

Ren,

Yu,

Xiao

et al. 2024

Brain and Behavior

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BackgroundNumerous studies have found that patients with systemic lupus erythematosus (SLE) often have comorbid headache, especially migraine. However, the causal relationship between genetically determined SLE and migraine risk remains unclear. Therefore, we conducted a Mendelian randomization (MR) study to explore this causal association.MethodsGenome‐wide association studies (GWAS) provided the instrumental variables. We selected summary data from GWAS of SLE as exposure (5201 SLE patients and 9066 controls). Both outcome GWAS data were from the Finnish Gene GWAS, including migraine with aura, migraine with aura and triptan purchases, and migraine without aura. The main MR approach was inverse‐variance weighted. Pleiotropy and heterogeneity were detected using the MR pleiotropy residual sum and outlier, MR‐Egger intercept test, leave‐one‐out analysis, and Cochran's Q test.ResultsThere was a significant association between genetically predicted SLE susceptibility and increased risk of migraine with aura [odds ratio (OR) = 1.05, 95% confidence interval (CI) = 1.02–1.08, p = .001]. The result was consistent when the outcome was migraine with aura and triptan purchases [OR = 1.05, 95% CI = 1.02–1.08, p = .001]. However, we found no association between SLE and migraine without aura. Our MR study showed no pleiotropy or heterogeneity.ConclusionsOur study indicates that genetic susceptibility to SLE increases the incidence of migraine with aura but not migraine without aura. It is necessary for the routine evaluation and early recognition of migraine in patients with SLE in clinical settings.

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Migraine with Aura: Surface-Based Analysis of the Cerebral Cortex with Magnetic Resonance Imaging

Cited by 31 publications

References 31 publications

Cortical thickness in migraine: a coordinate-based meta-analysis

Cortical thickness in migraine: a coordinate-based meta-analysis

Evaluation of the Optic Nerve by Strain and Shear Wave Elastography in Patients With Migraine

Causal association between systemic lupus erythematosus and the risk of migraine: A Mendelian randomization study

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