Midterm outcome of radiofrequency thermal ablation for symptomatic uterine myomas

Ghezzi, Fabio; Cromi, Antonella; Bergamini, Valentino; Scarperi, S.; Bolis, Pierfrancesco; Franchi, Massimo Piergiuseppe

doi:10.1007/s00464-007-9307-8

Cited by 70 publications

(51 citation statements)

References 26 publications

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“…Ghezzi and colleagues performed percutaneous RFA on up to three fibroids per patient in 25 women and followed them for 12 to 36 months. These patients all demonstrated symptomatic improvement and showed a mean 59% improvement in their quality of life with a 4% (1/25) reintervention rate at 1 year and as much as an 84% reduction in mean fibroid volumes at 36 months [9].…”

Section: Introductionmentioning

confidence: 93%

“…It has been shown that radiofrequency ablation results in heat/ thermal fixation and coagulative necrosis within the treated fibroids [9,10]. Recent studies have been performed using RFA in conjunction with simultaneous, real-time sonography to enable volumetric ablations that result in volume reduction and symptomatic relief [8,9,11].…”

Section: Introductionmentioning

confidence: 99%

“…Radiofrequency ablation (RFA) has been used as a fibroid treatment modality since the early 1990s, with multiple clinical studies confirming its safety and efficacy [4][5][6][7][8][9]. It has been shown that radiofrequency ablation results in heat/ thermal fixation and coagulative necrosis within the treated fibroids [9,10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Transcervical, intrauterine ultrasound-guided radiofrequency ablation of uterine fibroids with the VizAblate System: safety, tolerability, and ablation results in a closed abdomen setting

et al. 2011

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This was a single-site cohort study to evaluate the safety of a new transcervical device (VizAblate™) combining real-time intrauterine sonography with radiofrequency (RF) ablation for the treatment of fibroids. Nineteen women with uterine fibroids received treatment with the VizAblate System in a closed abdomen setting prior to hysterectomy. Twelve of these subjects underwent an immediate abdominal hysterectomy after radiofrequency ablation (acute group), while the remaining seven underwent hysterectomy on post-ablation days 16 and 17 (subacute group). Uteri were sectioned and stained with the viability stain triphenyltetrazolium chloride (TTC) to quantify fibroid ablation dimensions and assess the serosa for thermal injury. Subjects in the subacute group were treated with the VizAblate System under conscious sedation; they provided pain and tolerability data for the interval from ablation through hysterectomy, and indicated overall procedural satisfaction. Twenty-two ablations ranging from 1.8 to 36.2 cm 3 were created among 19 subjects within 20 fibroids and one region of adenomyosis. There were no complications or thermal serosal injury. For subjects in the subacute group receiving one ablation, the mean total procedure time was 25.8±6.0 min (range 18-32 min). All subjects in the subacute group were discharged within 2 h of the VizAblate procedure. For fibroids≤5 cm, 67.2%± 27.0% of the fibroid volume was ablated (range 15-100%; median 75%). Transcervical RF ablation of fibroids under intrauterine sonographic guidance with the VizAblate system can be accomplished with a high degree of reliability and without adverse events.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Transcervical, intrauterine ultrasound-guided radiofrequency ablation of uterine fibroids with the VizAblate System: safety, tolerability, and ablation results in a closed abdomen setting

et al. 2011

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“…Les symptômes et de la qualité de vie étaient significativement améliorés à partir de trois mois et pendant toute la durée de suivi : 10 mois. Ces femmes ont été revues au-delà d'un an avec des résultats inchangés, sauf une traitée par hystérectomie pour une récidive massive de myomes [17]. Elle associe cependant les risques de la coelioscopie à celui de la nécrose.…”

Section: L'embolisation Des Artères Utérinesunclassified

Contre la myomectomie en péri- ou en postménopause

Marret

2010

Gynécologie Obstétrique & Fertilité

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“…Medical therapy only an effect on the clinical symptoms based on long-term administration, and has adverse effects (6). A large variety of less invasive alternatives to hysterectomy have been developed, such as uterine artery embolization (UAE), high-intensity focused ultrasound (HIFU) and radiofrequency thermal ablation (7)(8)(9). Exposure to X-ray radiation is a persistent problem of UAE and may cause numerous complications (7).…”

Section: Introductionmentioning

confidence: 99%

Contrast‑enhanced ultrasound is better than magnetic resonance imaging in evaluating the short‑term results of microwave ablation treatment of uterine fibroids

Zhang

Fan

et al. 2017

Exp Ther Med

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Abstract. Contrast-enhanced ultrasound (CEUS) and magnetic resonance imaging (MRI) were compared in evaluating the short-term effects of microwave ablation (MWA) on uterine fibroids. A total of 60 patients with uterine fibroids treated by MWA were enrolled in the experimental group during their two-year follow-up period according to the inclusion criteria. Conventional two-dimensional US, MRI and CEUS were performed to determine the volume reduction and the fibroid residue by displaying the size, echo and signal intensity of fibroids prior to and after MWA treatment. As the control group, 60 consecutive patients were recruited on their follow-up visit at least two years after MWA treatment of uterine fibroids. Significant differences were observed in the wash-in rate (WiR) of the fibroid tissue, start time difference, rise time ratio (RTR) and WiR ratio between the experimental and control groups (P<0.05). However, the WiR of fibroid vessel, total area under the curve of fibroid vessel and tissue, and rise time difference (RTD) between fibroid vessel and tissue did not display any significant differences between the two groups. Fibroids were either reduced in volume or cured by MWA therapy in patients with uterine fibroids. The reductions in volume of hypointense, isointense and hyperintense fibroids were 62.42±18.13, 53.27±10.05 and 47.43±9.56%, respectively, on T1-weighted imaging (T1WI). On T2WI, the corresponding reductions were 67.32±32.63, 59.36±19.36 and 42.63±10.37%, respectively. The higher the signal intensity on T1WI and T2WI, the lower the reduction in volume. It is indicative that different blood supply to fibroids results in different ablation. CEUS was proved to be more effective than MRI in evaluating the effects of MWA on uterine fibroids during the first postoperative year.

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Midterm outcome of radiofrequency thermal ablation for symptomatic uterine myomas

Abstract: RFA of symptomatic fibroids seems a valuable alternative to major surgery, with durable symptom relief for most patients and a low chance of recurrence at midterm.

Cited by 70 publications

References 26 publications

Transcervical, intrauterine ultrasound-guided radiofrequency ablation of uterine fibroids with the VizAblate System: safety, tolerability, and ablation results in a closed abdomen setting

Transcervical, intrauterine ultrasound-guided radiofrequency ablation of uterine fibroids with the VizAblate System: safety, tolerability, and ablation results in a closed abdomen setting

Contre la myomectomie en péri- ou en postménopause

Contrast‑enhanced ultrasound is better than magnetic resonance imaging in evaluating the short‑term results of microwave ablation treatment of uterine fibroids

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