Midline perineal lesion in a newborn girl

Abstract

See http://onlinelibrary.wiley.com/doi/10.1111/jpc.2_14055/abstract

Perineal Groove in a Neonate With Increased Maternal Serum Alpha-Fetoprotein

“…The ectoderm gives rise to the central nervous system and epidermis, and the mesoderm gives rise to the muscle and skeletal systems as well as parts of the urogenital system. The embryological origins of the perineum and perineal groove are not agreed upon, although mechanisms for perineal groove formation include persistence of the cloacal duct [4,[7][8][9][10][11][12], failure of cloacal fold fusion between the vestibule and anus [3,[6][7][8][9][10][11][13][14][15], or occurrence of a defect of it is a remnant of the urorectal septum (URS) [9,11,16,17].…”

“…However, sometimes, it is initially misdiagnosed as other conditions, such as erosion [18], anal fissure [5], ulcerated hemangioma [19], infection [8,13], or diaper dermatitis [5,10,19]. The differential also includes contact dermatitis [8], lichen sclerosis [8], perianal pyramidal protrusion [8], and trauma [8,12]. Failure of treatment, such as cortisone/gen- Petrochko et al Int J Clin Pediatr.…”