Midbrain Raphe Modulation of Nonphotic Circadian Clock Resetting and 5-HT Release in the Mammalian Suprachiasmatic Nucleus

Glass, John D.; Grossman, Gregory H.; Farnbauch, Laure A.; DiNardo, Lisa

doi:10.1523/jneurosci.23-20-07451.2003

Cited by 152 publications

(118 citation statements)

References 51 publications

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“…Serotonin neurons originating in the dorsal and median raphe are thought to modulate SCN activity. 51,52 Due to circadian rhythms, time of day is an important consideration when performing research on living subjects. 53 Jurgen Aschoff, one of the founders of chronobiology, introduced the concept of "zeitgeber [time-giver] time" in the 1960s to simplify the reporting of results that were impacted by circadian-linked changes.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Physiologically Relevant Changes in Serotonin Resolved by Fast Microdialysis

Yang

Thompson²,

McIntosh³

et al. 2013

ACS Chem. Neurosci.

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Online microdialysis is a sampling and detection method that enables continuous interrogation of extracellular molecules in freely moving subjects under behaviorally relevant conditions. A majority of recent publications using brain microdialysis in rodents report sample collection times of 20−30 min. These long sampling times are due, in part, to limitations in the detection sensitivity of high performance liquid chromatography (HPLC). By optimizing separation and detection conditions, we decreased the retention time of serotonin to 2.5 min and the detection threshold to 0.8 fmol. Sampling times were consequently reduced from 20 to 3 min per sample for online detection of serotonin (and dopamine) in brain dialysates using a commercial HPLC system. We developed a strategy to collect and to analyze dialysate samples continuously from two animals in tandem using the same instrument. Improvements in temporal resolution enabled elucidation of rapid changes in extracellular serotonin levels associated with mild stress and circadian rhythms. These dynamics would be difficult or impossible to differentiate using conventional microdialysis sampling rates.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Physiologically Relevant Changes in Serotonin Resolved by Fast Microdialysis

Yang

Thompson²,

McIntosh³

et al. 2013

ACS Chem. Neurosci.

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“…Arousal or behavioral activity during the daytime (for nocturnal rodents) induce robust phase advances (Mrosovsky, 1988;Reebs et al, 1989;Antle and Mistlberger, 2000) that may involve neuropeptide Y (Biello et al, 1994;Golombek et al, 1996;Marchant et al, 1997) and/or serotonin (5-HT) (Prosser, 2003;Tominaga et al, 1992;Horikawa and Shibata, 2004;Marchant et al, 1997;Glass et al, 2003) signaling in the SCN. Interestingly, acute ethanol alters serotonergic signaling (Hayashi et al, 2003;Thielen et al, 2002;Daws et al, 2006), raising the possibility that ethanol could also affect the circadian system through modulating serotonergic signaling.…”

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confidence: 99%

Acute ethanol modulates glutamatergic and serotonergic phase shifts of the mouse circadian clock in vitro

2008

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Alcohol abuse is associated with sleep problems, which are often linked to circadian rhythm disturbances. However, there is no information on the direct effects of ethanol on the mammalian circadian clock. Acute ethanol inhibits glutamate signaling, which is the primary mechanism through which light resets the mammalian clock in the suprachiasmatic nucleus (SCN). Glutamate and light also inhibit circadian clock resetting induced by non-photic signals, including serotonin. Thus, we investigated the effects of acute ethanol on both glutamatergic and serotoninergic resetting of the SCN clock in vitro. We show that ethanol dose-dependently inhibits glutamate-induced phase shifts and enhances serotonergic phase shifts. The inhibition of glutamate-induced phase shifts is not affected by excess glutamate, glycine or D-serine, but is prevented by excess brain-derived neurotrophic factor (BDNF). BDNF is known to augment glutamate signaling in the SCN and to be necessary for glutamate/light-induced phase shifts. Thus, ethanol may inhibit glutamate-induced clock resetting at least in part by blocking BDNF enhancement of glutamate signaling. Ethanol enhancement of serotonergic phase shifts is mimicked by treatments that suppress glutamate signaling in the SCN, including antagonists of glutamate receptors, BDNF signaling and nitric oxide synthase. The combined effect of ethanol with these treatments is not additive, suggesting they act through a common pathway. Our data indicate further that the interaction between serotonin and glutamate in the SCN may occur downstream from nitric oxide synthase activation. Thus, acute ethanol disrupts normal circadian clock phase regulation, which could contribute to the physiological and psychological problems associated with alcohol abuse. Keywords suprachiasmatic nucleus; circadian rhythms; ethanol; glutamate; serotonin; brain-derived neurotrophic factorThe development of alcoholism and the likelihood of relapse drinking are associated with poor sleep quality and the deleterious effects of ethanol on sleep (Landolt and Gillin, 2001;Brower et al., 2001). Alcohol consumption reduces sleep quality (Kubota et al., 2002;Ehler and Slawecki, 2000;Landolt et al., 1996), which is closely linked to the circadian system. For example, the inability to fall asleep at the desired time can result from improper synchronization *Corresponding author: Dept. Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, phone: (865) 974-2722, FAX: (865)-974-6306, rprosser@utk.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal per...

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“…To the best of our knowledge, there are no data which would confirm the expression of these receptors in hippocampal interneurons. However, several authors have concluded that 5-HT 7 receptors are expressed, for example, in GABAergic cells in the DRN [20,21,29,80]. The increase in interneuron firing rate cannot account for the observed effect on sIPSCs frequency, as no 5-CT-induced changes in GABAergic interneuron excitability have been reported [93].…”

Section: The Effects Of 5-ht 7 Receptor Activation On Hippocampal Excmentioning

confidence: 99%

“…It has been speculated that 5-HT 7 receptor antagonistinduced increase in brain serotonin release is due to a complex GABA-glutamatergic-serotonergic interaction in the DRN [33,43,80] and it has been suggested that 5-HT release may be mediated via blockade of 5-HT 7 receptors localized on GABAergic interneurons in the DRN [21]. The studies conducted by Roberts et al [80] and Glass et al [29] have suggested that 5-HT 7 receptors in the DRN are localized, among others, on GABAergic cells. However, mainly due to the lack of selective agonists, there are no detailed characteristics of the effects of activation and blockade of the 5-HT 7 receptor in those brain structures, which are thought to be most important in the context of pathophysiology of affective disorders.…”

Section: Introductionmentioning

confidence: 99%

Stress- and antidepressant treatment-induced modifications of 5-HT7 receptor functions in the rat brain

Tokarski

Bobula

Grzegorzewska-Hiczwa

et al. 2012

Pharmacological Reports

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Abstract:This paper summarizes a series of electrophysiological studies aimed at finding the effects of the activation of 5-HT 7 receptors on neuronal excitability as well as on excitatory and inhibitory synaptic transmission in the hippocampus and in the frontal cortex of the rat. These studies demonstrated that 5-HT 7 receptors play an important role in the modulation of the activity of the hippocampal network by regulating the excitability of pyramidal cells of the CA1 area, as well as via their effect on GABA and glutamatergic transmission. The reactivity of 5-HT 7 receptors in the hippocampus is decreased by repeated administration of antidepressant drugs and increased by a prolonged high level of corticosterone. More importantly, administration of antidepressant drug, imipramine, prevents the occurrence of corticosterone-induced changes in the function of hippocampal 5-HT 7 receptors. It has also been found that the blockade of 5-HT 7 receptors by the selective antagonist SB 269970, lasting for a few days, causes similar changes to those observed after long-term administration of antidepressants. Thus, it seems that the pharmacological blockade of 5-HT 7 receptors produces faster effects compared to classic antidepressant drugs. A similarity between the changes in the glutamatergic transmission induced by the blockade of 5 HT 7 receptors and those caused by repeated administration of the antidepressant drug, imipramine, has also been found in the frontal cortex. It has also been shown that the changes in glutamatergic transmission and the impairment of long-term synaptic plasticity in the frontal cortex of animals subjected to repeated restraint stress are reversed by the blockade of 5-HT 7 receptors. Overall, these studies, together with the data provided by other investigators, support the hypothesis that 5-HT 7 receptor antagonists may become a prototype of a new class of antidepressant drugs. Such compounds will not function by blocking 5-HT reuptake, as many of the currently used drugs, but through a direct interaction with the 5-HT 7 receptor. This type of action is highly selective and usually does not require the occurrence of adaptive changes in neuronal functions, thus allowing for a much quicker therapeutic effect.

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Midbrain Raphe Modulation of Nonphotic Circadian Clock Resetting and 5-HT Release in the Mammalian Suprachiasmatic Nucleus

Cited by 152 publications

References 51 publications

Physiologically Relevant Changes in Serotonin Resolved by Fast Microdialysis

Physiologically Relevant Changes in Serotonin Resolved by Fast Microdialysis

Acute ethanol modulates glutamatergic and serotonergic phase shifts of the mouse circadian clock in vitro

Stress- and antidepressant treatment-induced modifications of 5-HT7 receptor functions in the rat brain

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