Mid-term clinical efficacy of a volumetric magnetic resonance-guided high-intensity focused ultrasound technique for treatment of symptomatic uterine fibroids

Ikink, Marlijne E.; Voogt, Marianne J.; Verkooijen, Helena M.; Lohle, Paul N.M.; Schweitzer, Karlijn J.; Franx, Arie; Mali, Willem P.Th.M.; Bartels, Lambertus W.; Bosch, Maurice A.A.J. van den

doi:10.1007/s00330-013-2915-x

Cited by 38 publications

(37 citation statements)

References 51 publications

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“…It is currently routinely used in the clinic for the ablation of uterine fibroids [1][2][3][4][5] and as a palliative treatment for painful bone metastases. [6][7][8][9][10][11] Furthermore, MR-HIFU could potentially be applied to treat lesions in abdominal organs.…”

Section: Introductionmentioning

confidence: 99%

Subject-specific four-dimensional liver motion modeling based on registration of dynamic MRI

et al. 2016

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Abstract. Magnetic resonance-guided high intensity focused ultrasound treatment of the liver is a promising noninvasive technique for ablation of liver lesions. For the technique to be used in clinical practice, however, the issue of liver motion needs to be addressed. A subject-specific four-dimensional liver motion model is presented that is created based on registration of dynamically acquired magnetic resonance data. This model can be used for predicting the tumor motion trajectory for treatment planning and to indicate the tumor position for treatment guidance. The performance of the model was evaluated on a dynamic scan series that was not used to build the model. The method achieved an average Dice coefficient of 0.93 between the predicted and actual liver profiles and an average vessel misalignment of 3.0 mm. The model performed robustly, with a small variation in the results per subject. The results demonstrate the potential of the model to be used for MRI-guided treatment of liver lesions. Furthermore, the model can possibly be applied in other image-guided therapies, for instance radiotherapy of the liver.

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Section: Introductionmentioning

confidence: 99%

Subject-specific four-dimensional liver motion modeling based on registration of dynamic MRI

et al. 2016

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“…The primary endpoint of the study, clinical efficacy, was based on the proportion of treated patients with fibroid shrinkage as measured with MRI without additional treatment (myomectormy, hysterectomy, uterine artery embolization, or MR-HIFU) during the follow-up period [20, 25, 26]. An image-based primary endpoint was selected in order to be in line with the Chinese SFDA Notice 222 (2007): Notice on the issuance of the relevant technical requirements for HIFU device.…”

Section: Methodsmentioning

confidence: 99%

The safety and effectiveness of volumetric magnetic resonance-guided high-intensity focused ultrasound treatment of symptomatic uterine fibroids: early clinical experience in China

Chen

Keserci²,

et al. 2016

J Ther Ultrasound

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BackgroundUterine fibroids are the most common benign tumor in women, and surgical intervention is still the main fibroid treatment. Patient demands have encouraged development of less-invasive methods such as high-intensity focused ultrasound (HIFU). This study aimed to evaluate the safety and effectiveness of magnetic resonance-guided high-intensity focused ultrasound therapy using a volumetric ablation technique in the treatment of symptomatic uterine fibroids in China.MethodsOne hundred and seven patients were enrolled and treated with magnetic resonance-guided high-intensity focused ultrasound in this study. Clinical efficacy was based on the proportion of patients with fibroid shrinkage (10 % volume reduction or more compared to baseline) at 6 months post treatment as measured with magnetic resonance imaging. The quality of life and symptom outcome was assessed using the uterine fibroid symptom and quality of life questionnaire with symptom severity scoring. Safety was primarily assessed by evaluating the reported adverse events.ResultsNinety nine of the 107 treated patients had fibroid shrinkage at 6 months post treatment. Resulting in an overall 93 % (95 % confidence interval 86–97 %) treatment success rate, p value <0.001; the symptom severity scoring and health-related quality of life at 6 months was statistically different from the screening symptom severity scoring at 0.05 level. Of 366 adverse events reported, there were no study procedure-related or device-related serious adverse events were in the study.ConclusionsThis study demonstrated that the volumetric magnetic resonance-guided high-intensity focused ultrasound device is safe and technically effective and can be utilized in clinically efficient treatments of symptomatic uterine fibroids.Trial registration NCT01588899

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“…New research has investigated the use of its foam variant (61). This technique has been successfully used to treat uterine fibroids and breast cancer (62,63). Preliminary results in its application towards vascular malformations are encouraging, however further clinical testing is necessary.…”

Section: Other Sclerosants and Therapiesmentioning

confidence: 99%

Venous malformations: clinical diagnosis and treatment

Behravesh

Yakes²,

Gupta

et al. 2016

Cardiovasc. Diagn. Ther.

176

150

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Venous malformation (VM) is the most common type of congenital vascular malformation (CVM). They are present at birth and are often symptomatic, causing morbidity and pain. VMs can be challenging to diagnose and are often confused with hemangioma in terminology as well as with imaging. An accurate clinical history and cross-sectional imaging are critical for diagnosis and for devising management. This manuscript will review imaging approaches to diagnosing VMs and current treatment strategies.

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Mid-term clinical efficacy of a volumetric magnetic resonance-guided high-intensity focused ultrasound technique for treatment of symptomatic uterine fibroids

Cited by 38 publications

References 51 publications

Subject-specific four-dimensional liver motion modeling based on registration of dynamic MRI

Subject-specific four-dimensional liver motion modeling based on registration of dynamic MRI

The safety and effectiveness of volumetric magnetic resonance-guided high-intensity focused ultrasound treatment of symptomatic uterine fibroids: early clinical experience in China

Venous malformations: clinical diagnosis and treatment

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