Multipoint appro ximation method (MAM) focuses on the development of metamodels for the objective and constraint functions in solving a mid-range optimization problem within a trust region. To develop an optimization technique applicable to mixed integer-continuous design optimization problems in wh ich the objective and constraint functions are computationally expensive and could be impossible to evaluate at some comb inations of design variables, a simple and efficient algorith m, coordinate search, is imp lemented in the MAM. Th is discrete optimization capability is examined by the well established benchmark problem and its effectiveness is also evaluated as the discreteness interval for discrete design variables is increased from 0.2 to 1. Furthermore, an application to the optimization of a lattice co mposite fuselage structure where one of design variables (number of helical ribs) is integer is also presented to demonstrate the efficiency of this capability.