Microwave irradiation synthesis of novel ramose chitosan-based-5-fluorouracil and research on its in vitro release

Li, Heping; Wang, Zhou-dong; Yu, Tao

doi:10.1007/s00044-009-9291-8

Cited by 12 publications

(4 citation statements)

References 33 publications

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“…As one of the most commonly prescribed anti-cancer agents, 5-FU, either alone or in combination with other anticancer agents, has been commonly applied for the treatments of various types of cancers 47 . A variety of chemically modified 5-FU derivatives have been synthesized to enhance their antitumor efficacy 48 , 49 , but their irregular oral absorption, low bioavailability and lack of specificity often result in poor clinical therapeutic outcomes 5 – 7 . In order to improve the oral bioavailability, a wide variety of polymers have been synthesized for direct or indirect attachment of 5-FU and its derivatives 50 , 51 .…”

Section: Discussionmentioning

confidence: 99%

Targeted delivery of 5-fluorouracil-1-acetic acid (5-FA) to cancer cells overexpressing epithelial growth factor receptor (EGFR) using virus-like nanoparticles

Gan

Rullah

Yong

et al. 2020

Sci Rep

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Chemotherapy is widely used in cancer treatments. However, non-specific distribution of chemotherapeutic agents to healthy tissues and normal cells in the human body always leads to adverse side effects and disappointing therapeutic outcomes. Therefore, the main aim of this study was to develop a targeted drug delivery system based on the hepatitis B virus-like nanoparticle (VLNP) for specific delivery of 5-fluorouracil-1-acetic acid (5-FA) to cancer cells expressing epithelial growth factor receptor (EGFR). 5-FA was synthesized from 5-fluorouracil (5-FU), and it was found to be less toxic than the latter in cancer cells expressing different levels of EGFR. The cytotoxicity of 5-FA increased significantly after being conjugated on the VLNP. A cell penetrating peptide (CPP) of EGFR was displayed on the VLNP via the nanoglue concept, for targeted delivery of 5-FA to A431, HT29 and HeLa cells. The results showed that the VLNP displaying the CPP and harboring 5-FA internalized the cancer cells and killed them in an EGFR-dependent manner. This study demonstrated that the VLNP can be used to deliver chemically modified 5-FU derivatives to cancer cells overexpressing EGFR, expanding the applications of the VLNP in targeted delivery of chemotherapeutic agents to cancer cells overexpressing this transmembrane receptor.

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Section: Discussionmentioning

confidence: 99%

Targeted delivery of 5-fluorouracil-1-acetic acid (5-FA) to cancer cells overexpressing epithelial growth factor receptor (EGFR) using virus-like nanoparticles

Gan

Rullah

Yong

et al. 2020

Sci Rep

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show abstract

“…Additionally, it has significant merits such as reducing side reactions and being solvent-free. 17,18 Therefore, it is our aim to combine ultrasound and microwave irradiation together in order to examine the inter-particle interactions that will bring striking changes in morphology transformation, composition and properties. In this study, SrWO 4 :Ln 3+ (Eu 3+ , Tb 3+ , Sm 3+ and Dy 3+ ) phosphors were successfully prepared in the presence of co-irradiation by both supersonic and microwave treatments under very low temperature (70 °C) in only 45 min.…”

Section: Introductionmentioning

confidence: 99%

Emissions and photocatalytic selectivity of SrWO4:Ln3+ (Eu3+, Tb3+, Sm3+ and Dy3+) prepared by a supersonic microwave co-assistance method

Zheng

Lin

Wang

2012

Photochem Photobiol Sci

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The chemical effects of high intensity ultrasound and microwave irradiation on lanthanide (Eu(3+), Tb(3+), Sm(3+) and Dy(3+)) activated SrWO(4) phosphors were extensively studied. Four classes of characteristic optically active materials (red, green, orange-red and blue-yellow) with striking luminescence were facilely prepared under very low temperature (70 °C) in 45 min. Particularly, Sm(3+), Dy(3+) and Eu(3+) doped strontium tungstates were visible-light driven emissive. The photocatalytic properties of these luminescent lanthanide doped tungstates were systematically examined by investigating the degradation behavior of different dyes.

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“…In this work, using the EDC / NHS as catalysts, CS-FU was synthesized successfully at room temperature. 9 It was found that reaction time was the most important influence factor in this reaction. The influence of reaction time on the drug loading and gel formation were shown in Fig.…”

Section: Synthesis Of Cs-fumentioning

confidence: 97%

Preparation and In Vitro Release of Ramose Chitosan-Based-5-Fluorouracil Microspheres

Li¹,

Li²,

Wang³

et al. 2013

Journal of the Korean Chemical Society

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ABSTRACT. In order to construct a controlled release system of drugs and to reduce toxic side effects of 5-fluorouracil, the novel ramose chitosan-based-5-fluorouracil microspheres (CS-FU-MS) were prepared. Firstly, using chitosan (CS) as carriers and 5-fluorouracil (5-FU) as a model drug, ramose chitosan-based-5-fluorouracil (CS-FU) was efciently synthesized by chemical crosslinking method through microwave irradiation, drug loading was 10.6%; Secondly, CS-FU-MS were prepared by CS-FU self-assembled under the dialysis conditions and the free 5-FU was encapsulated further at the same time. The size dispersivity of particles is uniform, and the average diameter of the CS-FU-MS was 4 µm. The drug encapsulation efficiency was 76.1%, and the drug loading was increased to 26.22%. CS-FU-MS maintain the zero-order release time in PBS (pH = 7.4) and HCl/KCl (pH = 1.2) dialysis medium was 40h and 34h respectively, and the cumulative release were 58.89% and 79.33% in 182 h. The results showed that CS-FU-MS have excellent sustained release properties.

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Microwave irradiation synthesis of novel ramose chitosan-based-5-fluorouracil and research on its in vitro release

Cited by 12 publications

References 33 publications

Targeted delivery of 5-fluorouracil-1-acetic acid (5-FA) to cancer cells overexpressing epithelial growth factor receptor (EGFR) using virus-like nanoparticles

Targeted delivery of 5-fluorouracil-1-acetic acid (5-FA) to cancer cells overexpressing epithelial growth factor receptor (EGFR) using virus-like nanoparticles

Emissions and photocatalytic selectivity of SrWO4:Ln3+ (Eu3+, Tb3+, Sm3+ and Dy3+) prepared by a supersonic microwave co-assistance method

Preparation and In Vitro Release of Ramose Chitosan-Based-5-Fluorouracil Microspheres

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