2018
DOI: 10.1159/000489739
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Abstract: Background/Aims: Chronic inflammation contributes to cartilage degeneration during the progression of osteoarthritis (OA). Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. In the present work, we have isolated and characterized the extracellular vesicles from human AD-MSC to investigate their role in the chondroprotective actions of these cells. Methods: AD-MSC were isolated… Show more

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Cited by 167 publications
(139 citation statements)
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“…Nitrite levels were analyzed in the supernatants from the OA models in vitro using a colorimetric assay with a Griess reagent kit (Invitrogen) . Briefly, 20 µL of Griess reagent, 130 µL of deionized water, and 150 µL of the supernatant or standard nitrite solution were mixed in each well in a 96‐well plate.…”
Section: Methodsmentioning
confidence: 99%
“…Nitrite levels were analyzed in the supernatants from the OA models in vitro using a colorimetric assay with a Griess reagent kit (Invitrogen) . Briefly, 20 µL of Griess reagent, 130 µL of deionized water, and 150 µL of the supernatant or standard nitrite solution were mixed in each well in a 96‐well plate.…”
Section: Methodsmentioning
confidence: 99%
“…Some specific protein components on the surface of MVs, such as ligand CD40 (CD40L), can stimulate endothelial cells to induce angiogenesis . MVs that express CD44 mediate the uptake by human chondrocytes, while up‐regulated annexin A1 in MVs assists in anti‐inflammatory and cartilage protection . In addition, The P‐selectin contained in platelet‐derived microvesicles (PMVs) could improve the kinetics of fibrinogenesis and normalize the bleeding time of haemophilia mice by targeting MVs to the injured site.…”
Section: Biological Effects Of Active Moleculesmentioning
confidence: 99%
“…In recent years, it has been found that MVs from mesenchymal stem cells can prevent unilateral ureteral obstruction and that endothelial progenitor cell (EPC)–derived MVs have played a protective role in renal ischaemia‐reperfusion injury . Furthermore, adipose tissue mesenchymal stem cell–derived MVs have effects of anti‐inflammatory and cartilage protection . The protective effect of MVs may be attributed to the fact that its parent cells are stem cells with regenerative and repairing effects.…”
Section: Introductionmentioning
confidence: 99%
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“…For example, synovial fibroblast‐derived EVs from osteoarthritis (OA) patients stimulate macrophages to produce a spectrum of proinflammatory cytokines and chemokines, which leads to a further acceleration of cartilage degradation . In contrast, EVs released from MSCs have been suggested to have therapeutic properties and inhibit cartilage degradation and inflammation in OA . These findings suggest that the cargo of EVs, which is responsible for EVs’ actions, not only depends on the parent cell type, but also on the state of the cell from which the EVs are released.…”
mentioning
confidence: 99%