2017
DOI: 10.1136/bmjopen-2016-013574
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Abstract: IntroductionThere are several randomised controlled trials (RCTs) that have already shown that metabolic/bariatric surgery achieves short-term and long-term glycaemic control while there are no level 1A of evidence data regarding the effects of surgery on the microvascular complications of type 2 diabetes mellitus (T2DM).PurposeThe aim of this trial is to investigate the long-term efficacy and safety of the Roux-en-Y gastric bypass (RYGB) plus the best medical treatment (BMT) versus the BMT alone to improve mi… Show more

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Cited by 26 publications
(20 citation statements)
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“…Frontiers in Endocrinology | www.frontiersin.org baseline eGFR <30 mL/min/BSA were excluded from the MOMS RCT and baseline eGFR was >60 mL/min/BSA in both study arms (40). An RCT which randomizes individuals with obesity, type 2 diabetes, severely increased albuminuria, and eGFR 30-60 mL/min/BSA to metabolic surgery plus best medical care or best medical care alone and assesses mGFR in a longitudinal fashion is required to determine the impact of metabolic surgery in those with more advanced type 2 DKD.…”
Section: What Is the Role Of Metabolic Surgery In The Management Of Tmentioning
confidence: 99%
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“…Frontiers in Endocrinology | www.frontiersin.org baseline eGFR <30 mL/min/BSA were excluded from the MOMS RCT and baseline eGFR was >60 mL/min/BSA in both study arms (40). An RCT which randomizes individuals with obesity, type 2 diabetes, severely increased albuminuria, and eGFR 30-60 mL/min/BSA to metabolic surgery plus best medical care or best medical care alone and assesses mGFR in a longitudinal fashion is required to determine the impact of metabolic surgery in those with more advanced type 2 DKD.…”
Section: What Is the Role Of Metabolic Surgery In The Management Of Tmentioning
confidence: 99%
“…No RCTs have yet assessed the impact of metabolic surgery on primary renal outcomes in people with type 2 DKD. The Microvascular Outcomes after Metabolic Surgery (MOMS) clinical trial, which randomised people with obesity (BMI 30–34.9 kg/m 2 ), type 2 diabetes and moderately increased albuminuria to best medical care plus Roux-en-Y gastric bypass surgery or best medical care alone, finished recruiting in 2016; 1, 2, and 5 year outcomes are awaited ( 40 ). Individuals with baseline eGFR <30 mL/min/BSA were excluded from the MOMS RCT and baseline eGFR was >60 mL/min/BSA in both study arms ( 40 ).…”
Section: What Is the Role Of Metabolic Surgery In The Management Of Tmentioning
confidence: 99%
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“…PRODIGIES (NCT01974544) involves 3 study arms (RYGB + IMT vs VSG + IMT vs IMT alone), has selectively recruited individuals with class 1 obesity (BMI <35 kg/m 2 ) and established or at high-risk for microalbuminuria, and will follow patients to 36 months postoperatively [100]. MOMS (NCT01821508) incorporates 2 study arms (RYGB + IMT vs IMT alone), has also selectively recruited individuals with class 1 obesity (BMI <35 kg/m 2 ), and will follow patients to 60 months postoperatively [101]. The final 60-month follow-up visit is scheduled for April 2021 in the MOMS study [101].…”
Section: Five-year Viewmentioning
confidence: 99%
“…Thus, as the complication burden amongst people with obesity and CKD is similar across obesity classes, and obesity classes 1 and 2 are much more prevalent than obesity class 3, it is plausible that the maximum benefit of intentional weight loss strategies in nephrology practice may be achieved in those with obesity classes 1 and 2. Indeed, the Microvascular Outcomes after Metabolic Surgery study, which randomized individuals with T2DM and microalbuminuria to medical therapy or medical therapy plus metabolic surgery, selectively recruited individuals with class 1 obesity 30 . Further prospective studies of intentional weight loss strategies across the spectrum of obesity severity in people with CKD are required.…”
Section: Discussionmentioning
confidence: 99%