2019
DOI: 10.1186/s13036-019-0158-3
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Abstract: Capillaries within the microcirculation are essential for oxygen delivery and nutrient/waste exchange, among other critical functions. Microvascular bioengineering approaches have sought to recapitulate many key features of these capillary networks, with an increasing appreciation for the necessity of incorporating vascular pericytes. Here, we briefly review established and more recent insights into important aspects of pericyte identification and function within the microvasculature. We then consider the impo… Show more

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Cited by 31 publications
(17 citation statements)
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“…The observed reduction of NHE1 expression in tissue samples indicates contribution of other cell types of the CNS that may play a role, which requires further investigation. For example, pericytes were not investigated in the current study given the challenges in fully distinguishing this cell type from others (vascular smooth muscle cells) in immortalized lines and primary culture in the CNS [30,[85][86][87]. Overall, our in vitro data suggest the active participation of endothelial cells in NHE1 regulation during periods when extracellular K + is high, including during cortical spreading depression events.…”
Section: Discussionmentioning
confidence: 89%
“…The observed reduction of NHE1 expression in tissue samples indicates contribution of other cell types of the CNS that may play a role, which requires further investigation. For example, pericytes were not investigated in the current study given the challenges in fully distinguishing this cell type from others (vascular smooth muscle cells) in immortalized lines and primary culture in the CNS [30,[85][86][87]. Overall, our in vitro data suggest the active participation of endothelial cells in NHE1 regulation during periods when extracellular K + is high, including during cortical spreading depression events.…”
Section: Discussionmentioning
confidence: 89%
“…), or those that enable horizontal genetic/biomaterial transfer including cfDNA, apoptotic bodies, CTCs, and exosomes BBB similar to those of the rat brain, with perfusable and selective microvascularization and lower permeability than the conventional in vitro model [37]. Similar 3D lab-on-chip vascular network systems involving pericytes are discussed in [38,39].…”
Section: Pericytesmentioning
confidence: 99%
“…The phenotypic and functional plasticity of mural cells depends on both the metabolic and nutrient transport demands of organ niches and their position along the vascular tree. [ 89,90 ]…”
Section: Vascular Hemodynamics and Mechanotransductionmentioning
confidence: 99%
“…[ 65,78,85,187 ] Mural cells not only engage in paracrine signaling with adjoining ECs, but also assist in remodeling the ECM through matrix protein deposition, proteolytic degradation, and matrix deformation via cell‐generated tension. [ 90,182,186,188 ] The formation and organization of vascular lumens and branch points with high vessel density, lacunarity, and network connectivity is closely reminiscent of the “tree‐like” capillary beds in organs with high blood vessel density. [ 30 ] These networks, during the process of assembly, can be connected to fluid reservoirs and microfluidic systems for cyclic or continuous controlled perfusion, simulative of interstitial flow, which provides additional guidance toward structural and functional maturation.…”
Section: Fabrication Strategies To Generate Microfluidic and Vascularmentioning
confidence: 99%