Microstructured optical fiber-based luminescent biosensing: Is there any light at the end of the tunnel? - A review

Pidenko, Sergey A.; Бурмистрова, Н. А.; Shuvalov, A. A.; Chibrova, Anastasiya A.; Skibina, Julia S.; Goryacheva, Irina Yu.

doi:10.1016/j.aca.2017.12.010

Cited by 33 publications

(12 citation statements)

References 85 publications

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“…In addition to all the other advantages and features of OFSs, MOFs with their capability to guide light in the HC region and the strong interaction with an injected medium open new perspectives for the applications of OFSs, which are not possible with all-solid fibers [32,[38][39][40]. The liquid filling of hollow capillaries of MOFs, enables in-fiber microfluidic optical sensing, measurements of the fluid's refractive index [31,34,35], temperature [41], and fluorescence signals [42]. The high sensitivity to the change of solution refractive index enables the precise measurement of concentration in a very little analyte volume needed for the test (Figure 4).…”

Section: Microstructured Optical Fiber-based Optical Sensorsmentioning

confidence: 99%

“…An overview of the existing functionalization techniques and applied materials [108], their comparison, and the application areas can be found in References [32,38,42,52,103,109]. Table 1 summarizes the reviewed techniques applied for MOFs functionalization, their potential applications, and describes the used MOF types.…”

Section: Summary Of the Reviewed Functionalized Techniquesmentioning

confidence: 99%

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Functionalized Microstructured Optical Fibers: Materials, Methods, Applications

et al. 2020

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Microstructured optical fiber-based sensors (MOF) have been widely developed finding numerous applications in various fields of photonics, biotechnology, and medicine. High sensitivity to the refractive index variation, arising from the strong interaction between a guided mode and an analyte in the test, makes MOF-based sensors ideal candidates for chemical and biochemical analysis of solutions with small volume and low concentration. Here, we review the modern techniques used for the modification of the fiber’s structure, which leads to an enhanced detection sensitivity, as well as the surface functionalization processes used for selective adsorption of target molecules. Novel functionalized MOF-based devices possessing these unique properties, emphasize the potential applications for fiber optics in the field of modern biophotonics, such as remote sensing, thermography, refractometric measurements of biological liquids, detection of cancer proteins, and concentration analysis. In this work, we discuss the approaches used for the functionalization of MOFs, with a focus on potential applications of the produced structures.

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Section: Microstructured Optical Fiber-based Optical Sensorsmentioning

confidence: 99%

Section: Summary Of the Reviewed Functionalized Techniquesmentioning

confidence: 99%

Functionalized Microstructured Optical Fibers: Materials, Methods, Applications

et al. 2020

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“…To implement of our general-purpose system, many examples in literature [19], [20], [21], [22], [25], and many reviewpapers [3], [18], [4], [6], [7], [8], [24], [25], have been methodically analyzed to define the technical requirements for fitting to the highest possible number of applications. The device is divided into its three parts (front-end, back-end, and core) and the parts requiring to be application-specific customized are carefully separated from the rest of the system.…”

Section: The Approachmentioning

confidence: 99%

“…According to the definition, the world of biosensors is an extensive collection of systems and devices, which exploit different working principles depending on the different target molecules [3], [4]. Just to list some examples, biosensors could leverage on electrochemistry [5], acoustic techniques [6], surface plasmon resonance [7], or luminescent principles [8]. Due to the large variety of biosensing techniques, it is not possible to develop a system capable of interfacing with all types of biological detector.…”

Section: Introductionmentioning

confidence: 99%

New Approach for Making Standard the Development of Biosensing Devices by a Modular Multi-Purpose Design

Tuoheti

Aiassa

Criscuolo

et al. 2020

IEEE Trans.on Nanobioscience

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The fast widening of biosensing applications, such as healthcare, drug delivery, food, and military industries, is increasing the need for generality and compatibility among different sensors. To address this challenge, we present here an innovative approach for the fast development of new electronic biosensing systems, linking a custom-designed front-end with a multipurpose system. We envision an open tool to help designers to focus on the target molecule and related detection method instead of designing each time a dedicated electronic device. The architecture of the proposed system is based on a modular approach, where only the front-end and the software need to be custom redesigned according to the application. Considering current research and applying a rigorous definition of the technical requirements, the core of the system is designed to fit the highest number of biosensing methods. The flexibility of this approach is successfully demonstrated with three different types of biosensors, i.e., amperometric, ion-sensitive, and memristive.

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“…A photonic crystal fiber (PCF) and microstructured waveguide (MWG) are the light-waveguided devices that consist of a central core and a periodic grating structure of claddings formed by either welded microcapillaries or holes in the solid structure [ 1 , 2 , 3 , 4 , 5 ]. There can be a number of different fiber structures (PCFs) that have light-waveguiding properties [ 6 ]. The two major types of PCFs are solid core PCFs (SC PCFs) and hollow core PCFs (HC PCFs), containing high and low refractive index material in the core, respectively.…”

Section: Introductionmentioning

confidence: 99%

Microstructured Waveguides with Polyelectrolyte-Stabilized Gold Nanostars for SERS Sensing of Dissolved Analytes

et al. 2018

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A sensor based on microstructured waveguides (MWGs) with a hollow core inner surface covered with polyelectrolyte-layer-stabilized gold nanostars was developed for the SERS sensing of dissolved analytes. A polyelectrolyte-layer coating over the inner surface of glass cladding served as a spacer, reducing nonlinear optical effects in the glass near plasmonic hotspots of nanoparticles, as a stabilizing agent for thermodynamically unstable gold nanostars and as an optical coating for the fine-tuning of MWG bandgaps. This approach can be used to construct different kinds of SERS sensors for dissolved analytes, providing conservation, the prevention of coagulation, and the drying of a liquid sample for the time required to record the signal.

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Microstructured optical fiber-based luminescent biosensing: Is there any light at the end of the tunnel? - A review

Cited by 33 publications

References 85 publications

Functionalized Microstructured Optical Fibers: Materials, Methods, Applications

Functionalized Microstructured Optical Fibers: Materials, Methods, Applications

New Approach for Making Standard the Development of Biosensing Devices by a Modular Multi-Purpose Design

Microstructured Waveguides with Polyelectrolyte-Stabilized Gold Nanostars for SERS Sensing of Dissolved Analytes

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