Microstructure, Mechanical, and Biological Properties of Porous Poly(vinylidene fluoride) Scaffolds Fabricated by Selective Laser Sintering

Huang, Wei; Feng, Pei; Gao, Chengde; Shuai, Xiong; Xiao, Tao; Shuai, Cijun; Peng, Shuping

doi:10.1155/2015/132965

Cited by 5 publications

(9 citation statements)

References 25 publications

(26 reference statements)

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“…Furthermore, this technique is a low-cost process in comparison to SLS, while affording greater control of pore size (the minimum achievable in SLS is currently 400-500 μm). Therefore, while SLS as an AM technology has greater control on pore size and architecture of bioconstructs [42,43] , its use in clinical applications is currently limited to those in which small pore sizes are not required. In contrast, with the use of the proposed technique, a wide range of pore sizes (200-1000 µm) is achievable.…”

Section: Discussionmentioning

confidence: 99%

A novel bioactive PEEK/HA composite with controlled 3D interconnected HA network

Vaezi¹,

Yang²

2024

IJB

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Polyetheretherketone (PEEK) is a high-performance thermoplastic biomaterial which is currently used in a variety of biomedical orthopaedic applications. It has comparable tensile and compressive strength to cortical bone with favourable biocompatibility. However, natural grade PEEK-OPTIMA has shown insufficient bioactivity and limited bone integration. Bioactive PEEK composites (e.g., PEEK/calcium phosphates or Bioglass) and porous PEEK have been used to improve bone-implant interface of PEEK-based devices, but the bioactive phase distribution or porosity control is poor. In this paper, a novel method is developed to fabricate a bioactive PEEK/hydroxyapatite (PEEK/HA) composite with a unique configuration in which the HA (bioactive phase) distribution is computer-controlled within a PEEK matrix. This novel process results in complete interconnectivity of the HA network within a composite material, representing a superior advantage over alternative forms of product. The technique combines extrusion freeforming, a type of additive manufacturing (AM), and compression moulding. Compression moulding parameters, including pressure, temperature, dwelling time, and loading method together with HA microstructure were optimized by experimentation for successful biocomposite production. PEEK/HA composites with a range of HA were produced using static pressure loading to minimise air entrapment within PEEK matrix. In addition, the technique can also be employed to produce porous PEEK structures with controlled pore size and distribution.

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Section: Discussionmentioning

confidence: 99%

A novel bioactive PEEK/HA composite with controlled 3D interconnected HA network

Vaezi¹,

Yang²

2024

IJB

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“…Scaffold needs to replicate as closely as possible in the composition, structure, and function which could transfer the loading function to fully replace newly formed tissue after degradation. 18 Composition such as the biomaterials used to fabricate scaffold also need to be selected based on the properties construct such as different types of tissue for skins, 19 organs, 20,21 or orthopedic 22,23,24,25 and implants which have different structural requirements. The structure such as porosity and internal architecture of the scaffold needed to allow nutrient transfer after implantation.…”

Section: Te Scaffolds Characteristicsmentioning

confidence: 99%

“…8 Figure 3 shows the classification of AM technologies with some of their categories, processes, and materials used. There are seven different processes of AM technologies which are broadly used in TE such as extruded-based process from thermoplastic filaments FDM, 32,33,34,35 powder-based process SLS, 24,25,36 liquid-based process SLA, 37,38,39,40,41 sheet lamination process laminated object manufacturing (LOM), 42 binder jetting process inkjet, 43,44 material jetting process, and direct energy deposition (DED) process. Details of different processes will be introduced in the following subsections.…”

Section: Am Technologies In Tementioning

confidence: 99%

“…Scaffold can be fabricated by SLS with any biomaterial that can be fused but not decomposed under a laser beam. 64 For example, biomaterials such as polyvinylidene fluoride (PVDF), 25 PCL biodegradable polymer, 65,66 polyamide (PA), 65 PLA, 66 and poly(ether-ether-ketone) (PEEK) with HA bio-composite blends 67 were investigated in various TE applications.…”

Section: Am Technologies In Tementioning

confidence: 99%

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A review of biomaterials scaffold fabrication in additive manufacturing for tissue engineering

Shick

Kadir

Ngadiman

et al. 2019

Journal of Bioactive and Compatible Polymers

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The current developments in three-dimensional printing also referred as “additive manufacturing” have transformed the scenarios for modern manufacturing and engineering design processes which show greatest advantages for the fabrication of complex structures such as scaffold for tissue engineering. This review aims to introduce additive manufacturing techniques in tissue engineering, types of biomaterials used in scaffold fabrication, as well as in vitro and in vivo evaluations. Biomaterials and fabrication methods could critically affect the outcomes of scaffold mechanical properties, design architectures, and cell proliferations. In addition, an ideal scaffold aids the efficiency of cell proliferation and allows the movements of cell nutrient inside the human body with their specific material properties. This article provides comprehensive review that covers broad range of all the biomaterial types using various additive manufacturing technologies. The data were extracted from 2008 to 2018 mostly from Google Scholar, ScienceDirect, and Scopus using keywords such as “Additive Manufacturing,” “3D Printing,” “Tissue Engineering,” “Biomaterial” and “Scaffold.” A 10 years research in this area was found to be mostly focused toward obtaining an ideal scaffold by investigating the fabrication strategies, biomaterials compatibility, scaffold design effectiveness through computer-aided design modeling, and optimum printing machine parameters identification. As a conclusion, this ideal scaffold fabrication can be obtained with the combination of different materials that could enhance the material properties which performed well in optimum additive manufacturing condition. Yet, there are still many challenges from the printing methods, bioprinting and cell culturing that needs to be discovered and investigated in the future.

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“…In this study, PVDF is chosen as a representative polymer matrix. PVDF is a very important engineering polymer with broad applications in electronics [37,38], purification/separation [39,40], and biological applications [41]. PVDF has a good binding affinity with proteins, and therefore, PVDF membranes have been frequently used in Western blotting applications in molecular biology [42].…”

Section: Introductionmentioning

confidence: 99%

Numerical study on mechanisms of soy protein as a functional modifier for polymer materials

Zheng

Chen

2019

Modelling Simul. Mater. Sci. Eng.

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In the past decades, to meet the increasing demands for protecting the environments, taking bio-degradable green materials as alternatives to traditional petroleum-based polymer materials has become a global interest. From the previous studies, it is demonstrated that soy protein-based biomaterial is one of the promising candidates to be used as functional modifier for polymers, due to the complex structures of protein and diverse interactions with polymers. However, the underlying mechanisms remain unclear. Molecular dynamic (MD) simulation is a power tool and can provide insights in understanding the conformational changes of protein molecules, as well as the interactions between proteins and polymers. In this study, 11S molecule of soy protein is chosen as a representative, and three different denaturation processes are applied via MD simulation, including heat denaturation at two temperatures and the breaking of disulfide bonds. It is observed that by controlling the denaturation conditions, the structures and properties of the protein molecules can be manipulated. Low temperature condition has limited impacts on the structures and properties of 11S molecules; high temperature process, on the other hand, is found to lead to an intensive secondary phase transition of the molecules; moreover, by breaking the disulfide bonds, the hydrophobic residues of the molecules can be largely exposed, potentially forming strong interactions with the hydrophobic poly(vinylidene fluoride) (PVDF) polymer. Besides, different protein-polymer interactions could result in various property-modification effects on PVDF polymer. For instance, due to the strong interaction between PVDF and the protein molecule denatured without disulfide bonds, the dipole moment of PVDF at the interface is largely enhanced, and the polarizability under external electric fields is also improved, which is in agreement with experimental result.

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Microstructure, Mechanical, and Biological Properties of Porous Poly(vinylidene fluoride) Scaffolds Fabricated by Selective Laser Sintering

Cited by 5 publications

References 25 publications

A novel bioactive PEEK/HA composite with controlled 3D interconnected HA network

A novel bioactive PEEK/HA composite with controlled 3D interconnected HA network

A review of biomaterials scaffold fabrication in additive manufacturing for tissue engineering

Numerical study on mechanisms of soy protein as a functional modifier for polymer materials

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