Microstimulation mapping of the basal forebrain in the anesthetized rat: The “preoptic locomotor region”

Sinnamon, Harry M.

doi:10.1016/0306-4522(92)90392-f

Cited by 41 publications

(21 citation statements)

References 59 publications

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“…Therefore, a more direct mechanism such as an estrogenic effect on the central nervous system influencing the animal`s willingness to run is more likely the cause of the rapid changes in physical activity. Several brain areas regulate physical activity in rodents, including forebrain regions such as the medial preoptic area, hypothalamic paraventricular nucleus, lateral hypothalamic area and nucleus accumbens, and the midbrain ventral tegmental area (7,37,41). Neuromodulators such as dopamine, orexin A, and nerve growth factors are connected to physical activity in rodents, and they affect activity acutely, that is, within minutes to hours when injected into specific areas of the brain (17,39,41).…”

Section: Studymentioning

confidence: 99%

“…We speculate that the high wheel running of our tamoxifen-treated mice was attributable to agonistic effects of tamoxifen in areas of the brain associated with physical activity. For example, the hypothalamus is a potential area of importance because it is involved in estrogen-related regulation of physical activity in rodents (37), and tamoxifen has an agonistic effect in this area when estrogen is absent (32).…”

Section: Studymentioning

confidence: 99%

See 1 more Smart Citation

Estradiol and Tamoxifen Reverse Ovariectomy-Induced Physical Inactivity in Mice

Gorzek

Hendrickson

Forstner

et al. 2007

Medicine &Amp; Science in Sports &Amp; Exercise

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Section: Studymentioning

confidence: 99%

Section: Studymentioning

confidence: 99%

Estradiol and Tamoxifen Reverse Ovariectomy-Induced Physical Inactivity in Mice

Gorzek

Hendrickson

Forstner

et al. 2007

Medicine &Amp; Science in Sports &Amp; Exercise

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“…The BNST also projects directly to the VTA which, through its dopaminergic projection to the nucleus accumbens, has been shown to be critically involved in the incentive effects of motivationally significant stimuli, including drugs of abuse (Wise, 1996). In addition, neurones of the "preoptic locomotor region", which extends to and overlaps with the ventrolateral region of the BNST, have been found to induce forward locomotion and approach behaviours, possibly through a projection to the VTA (Sinnamon, 1992). In addition, neurones of the "preoptic locomotor region", which extends to and overlaps with the ventrolateral region of the BNST, have been found to induce forward locomotion and approach behaviours, possibly through a projection to the VTA (Sinnamon, 1992).…”

Section: Behaviours-significance For Of Stress-induced Relapsementioning

confidence: 99%

Stress-induced Relapse to Drug Seeking in the Rat; Role of the Bed Nucleus of the Stria Terminalis and Amygdala

Erb¹,

Shaham²,

Stewart³

2001

Stress

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There is growing interest in the role that the bed nucleus of the stria terminalis (BNST) and central nucleus of the amygdala (CeA), components of the extended amygdala, play in drug addiction. Within the BNST and CeA, there is an extensive system of intrinsic, primarily GABAergic, interconnections known to synthesize a variety of neuropeptides, including corticotrophin-releasing factor (CRF). The actions of CRF at extrahypothalamic sites,including the BNST and CeA, have been implicated in stress responses and in the aversive effects of withdrawal from drugs of abuse. Most recently, we have shown a critical role for extrahypothalamic CRF in stress-induced reinstatement of drug seeking in rats. In attempting to determine which brain circuitry mediates the effect of stress on relapse and, more specifically, where in the brain CRF acts to initiate the behaviours involved in relapse, we focused on the BNST and CeA. In the present paper, we summarize studies we have conducted that explore the role of these brain sites in stress-induced relapse to heroin and cocaine seeking, and then consider how our findings can be understood within the more general context of what is known about the role of the BNST and CeA in stress-related and general approach behaviours, such as drug seeking.

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“…The subcommissural basal forebrain, in conjunction with parts of the lateral hypothalamus and zona incerta (Sinnamon, 1992; 1993; Mitrofanis, 2005; Yetnikoff et al, 2015), is thought to comprise the final telencephalic link in circuitry conveying information from the prefrontal cortex, hippocampus and amygdala to the motivational circuitry and brainstem motor effectors (Heimer et al, 1985; 1995). Like all parts of brain, the subcommissural region is anatomically and functionally complex (Alheid and Heimer, 1988; Heimer et al, 1991; Heimer and Alheid, 1991; Heimer et al, 1997; Heimer and Van Hoesen, 2006) and it has been reported recently (Zahm et al, 2014) that the remarkably invigorated but otherwise structurally normal locomotion and rearing elicited by infusing bic into one of its subdivisions, the lateral preoptic area (LPO), look nothing like the postural twisting, vigorous pivoting movements, gnawing and compulsive ingesting that result from infusing bic into the ventral pallidum (VP), another, adjacent, subcommissural structure (Heimer, 1972; Heimer and Van Hoesen, 1978; Heimer et al, 1982; Zahm and Brog, 1992; Root et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Lateral preoptic and ventral pallidal roles in locomotion and other movements

et al. 2018

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The lateral preoptic area (LPO) and ventral pallidum (VP) are structurally and functionally distinct territories in the subcommissural basal forebrain. It was recently shown that unilateral infusion of the GABA receptor antagonist, bicuculline, into the LPO strongly invigorates exploratory locomotion, whereas bicuculline infused unilaterally into the VP has a negligible locomotor effect, but when infused bilaterally, produces vigorous, abnormal pivoting and gnawing movements and compulsive ingestion. This study was done to further characterize these responses. We observed that bilateral LPO infusions of bicuculline activate exploratory locomotion only slightly more potently than unilateral infusions and that unilateral and bilateral LPO injections of the GABA receptor agonist muscimol potently suppress basal locomotion, but only modestly inhibit locomotion invigorated by amphetamine. In contrast, unilateral infusions of muscimol into the VP affect basal and amphetamine-elicited locomotion negligibly, but bilateral VP muscimol infusions profoundly suppress both. Locomotor activation elicited from the LPO by bicuculline was inhibited modestly and profoundly by blockade of dopamine D2 and D1 receptors, respectively, but was not entirely abolished even under combined blockade of dopamine D1 and D2 receptors. That is, infusing the LPO with bic caused instances of near normal, even if sporadic, invigoration of locomotion in the presence of saturating dopamine receptor blockade, indicating that LPO can stimulate locomotion in the absence of dopamine signaling. Pivoting following bilateral VP bicuculline infusions was unaffected by dopamine D2 receptor blockade, but was completely suppressed by D1 receptor blockade. The present results are discussed in a context of neuroanatomical and functional organization underlying exploratory locomotion and adaptive movements.

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Microstimulation mapping of the basal forebrain in the anesthetized rat: The “preoptic locomotor region”

Cited by 41 publications

References 59 publications

Estradiol and Tamoxifen Reverse Ovariectomy-Induced Physical Inactivity in Mice

Estradiol and Tamoxifen Reverse Ovariectomy-Induced Physical Inactivity in Mice

Stress-induced Relapse to Drug Seeking in the Rat; Role of the Bed Nucleus of the Stria Terminalis and Amygdala

Lateral preoptic and ventral pallidal roles in locomotion and other movements

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