1979
DOI: 10.1001/archderm.115.6.706
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Microscopically controlled surgery for extramammary Paget's disease

Abstract: In five cases of extramammary Paget's disease (EMPD), the neoplasms were removed under complete microscopical control by means of fixed-tissue chemosurgical technique in one case and fresh-tissue technique in four cases. In each lesion there were histologically involved areas extending several centimeters into clinically normal-appearing skin. All patients have been free of the disease for periods from four months to nine years. Other authors using conventional surgery have reported a recurrence rate of 44%. M… Show more

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Cited by 36 publications
(32 citation statements)
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“…Se recomienda la extirpación mediante cirugía micrográ-fi ca de Mohs 10,11 o extirpación y estudio histológico diferido y reconstrucción en un segundo tiempo operatorio. Cuando se asocia carcinoma anal el procedimiento de elección es la resección abdominoperineal junto a resección de la lesión cutánea 11 .…”
Section: Discussionunclassified
“…Se recomienda la extirpación mediante cirugía micrográ-fi ca de Mohs 10,11 o extirpación y estudio histológico diferido y reconstrucción en un segundo tiempo operatorio. Cuando se asocia carcinoma anal el procedimiento de elección es la resección abdominoperineal junto a resección de la lesión cutánea 11 .…”
Section: Discussionunclassified
“…The reason behind the high recurrence rate even after extensive resection is the multicentric nature of EMPD which causes the intrasurgical frozen section analysis of the margins to be misleading [19]. Moh's micrographic surgery has shown promise for reducing local recurrence rates in EMPD [20]. …”
Section: Discussionmentioning
confidence: 99%
“…However, wide excision with an adequate margin (1.5-3 cm) is generally the recommended method. The optimal surgical resection margin is often difficult to establish, owing to the irregular and geographically shaped margins of EMPD, and the fact that tumor invasion may precede the visible changes of the skin lesion [4]. To solve this problem, Mohs micrographic surgery (MMS) or intraoperative frozen biopsy is usually performed to establish the surgical excision margin.…”
Section: Introductionmentioning
confidence: 99%