Microsatellite instability states serve as predictive biomarkers for tumors chemotherapy sensitivity

Ye, T; Lin, Anqi; Qiu, Zhengang; Hu, Shulu; Zhou, Chaozheng; Han, Xinwei; Cheng, Quan; Zhang, Jian; Luo, Peng

doi:10.1016/j.isci.2023.107045

Cited by 3 publications

(1 citation statement)

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“…Microsatellite Instability (MSI) is the accumulation of insertion or deletion errors at microsatellite repeat sequences in cancerous cells as a result of de cient mismatch repair (dMMR) [4][5]. Features associated with MSI can lead to the formation of a variety of tumors, including CRC (15% with MSI), stomach adenocarcinoma (STAD, 15% with MSI), uterine corpus endometrial carcinoma (UCEC, 20-30% with MSI) and ovarian serous cystadenocarcinoma (OV, 12% with MSI) [6][7].…”

Section: Introductionmentioning

confidence: 99%

Design and synthesis of N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as potential Werner-dependent anticancer agents

Li,

Yu,

et al. 2024

Preprint

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To discover new Werner (WRN) helicase inhibitors, a series of N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives were designed and synthesized through structural optimization strategy and the anticancer activities of 25 new target compounds against PC3, K562, and HeLa cell lines were evaluated by MTT assay. Some of it exhibited excellent inhibitory activity against three different cancer cells. In order to further verify whether the anticancer activity of these compounds is dependent on WRN, the PC3 cells with WRN overexpression (PC3-WRN) were constructed to further study their anticancer potence in vitro, the inhibition ratio and IC20 values showed that compounds 6a, 8i, and 13a were more sensitive to PC3-WRN than the control group cells (PC3-NC). The further study demonstrated that 13a was the most sensitivity in PC3-WRN among these tested compounds. In summary, our research provided a series of N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as potential WRN-dependent anticancer agents.

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Section: Introductionmentioning

confidence: 99%