2019
DOI: 10.1293/tox.2019-0054
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Abstract: MicroRNAs are short non-coding RNAs that have been widely recognized as key mediators in the epigenetic control of gene expression and which are present in virtually all cells and tissues studied. These regulatory molecules are generated in multiple steps in a process called microRNA biogenesis. Distinct microRNA expression patterns during the different stages of oocyte and embryo development suggest important regulatory roles for these small RNAs. Moreover, studies antagonizing specific microRNAs and enzymes … Show more

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Cited by 23 publications
(15 citation statements)
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“…The biogenesis of miRNA involves the formation of hairpin precursors from larger transcripts, and these precursors serve as substrates for Drosha and Dicer, members of the RNase III enzyme family, to generate mature 20-22 nucleotide single-stranded miRNAs (Lee et al, 2003). A single miRNA can target hundreds of genes and small changes in specific miRNA levels may have multiple downstream effects on cellular functions (Sabry et al, 2019).…”
Section: Prenatal Bpa Exposure and Its Impact On Functional Mirnas mentioning
confidence: 99%
See 1 more Smart Citation
“…The biogenesis of miRNA involves the formation of hairpin precursors from larger transcripts, and these precursors serve as substrates for Drosha and Dicer, members of the RNase III enzyme family, to generate mature 20-22 nucleotide single-stranded miRNAs (Lee et al, 2003). A single miRNA can target hundreds of genes and small changes in specific miRNA levels may have multiple downstream effects on cellular functions (Sabry et al, 2019).…”
Section: Prenatal Bpa Exposure and Its Impact On Functional Mirnas mentioning
confidence: 99%
“…In recent years, microRNAs (miRNAs) have been widely recognized as key mediators in the epigenetic control of gene expression, that act post‐transcriptionally to suppress gene expression through complementary binding to mRNA targets, usually in the 3′‐untranslated region (Bhaskaran & Mohan, 2014; Sabry, Yamate, Favetta, & LaMarre, 2019). miRNAs are short non‐coding RNAs and play a crucial role in many fundamental cellular processes, including embryonic development, proliferation and apoptosis (Lee et al, 2004; Vaucheret, Vazquez, Crete, & Bartel, 2004).…”
Section: Introductionmentioning
confidence: 99%
“…Sabry et al . (2019) demonstrated BPA to interfere with estrogen secretion by affecting the expression of miRNAs, ultimately resulting in infertility and abnormal reproduction. BPA can increase the expression of miR‐224 in ovarian granulosa cells, thereby increasing the level of estradiol in serum, reducing follicle‐stimulating hormone levels, and affecting female fertility (Lite et al ., 2019).…”
Section: Noncoding Rnas and The Reproductive Toxicity Of Eedsmentioning
confidence: 99%
“…In addition, we further selected studies with high-throughput sequencing data, such as toxico-epigenomics study cases. Because a comprehensive review has only published the miRNA changes induced by BPA exposure, we will not review the miRNA and ncRNA parts in this review ( Sabry et al, 2019 ; Farahani et al, 2020 ).…”
Section: Introductionmentioning
confidence: 99%