MicroRNAs and Stem-like Properties: The Complex Regulation Underlying Stemness Maintenance and Cancer Development

Divisato, Giuseppina; Piscitelli, Silvia; Elia, Mariantonietta; Cascone, Emanuela; Parisi, Silvia

doi:10.3390/biom11081074

Cited by 10 publications

(6 citation statements)

References 298 publications

(382 reference statements)

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“…Intriguingly, the maturity of some miRNAs bypass one or more steps in the classical pathway. These nonclassical miRNAs are similar to classical miRNAs in structure and function ( Divisato et al, 2021 ). The maturation process of nonclassical miRNAs, derived from introns, snoRNAs, endogenous short hairpin RNAs, and tRNAs, does not depend on the processing of Drosha / Dgcr8 , but only Dicer ( Abdelfattah et al, 2014 ).…”

Section: Mirnas Involved In the Osteogenic Differentiation Of Bmscsmentioning

confidence: 81%

The Emerging Role of Non-Coding RNAs in Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells

Chen

Xie

Zhang

et al. 2022

Front. Cell Dev. Biol.

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Autologous bone marrow-derived mesenchymal stem cells (BMSCs) are more easily available and frequently used for bone regeneration in clinics. Osteogenic differentiation of BMSCs involves complex regulatory networks affecting bone formation phenomena. Non-coding RNAs (ncRNAs) refer to RNAs that do not encode proteins, mainly including microRNAs, long non-coding RNAs, circular RNAs, piwi-interacting RNAs, transfer RNA-derived small RNAs, etc. Recent in vitro and in vivo studies had revealed the regulatory role of ncRNAs in osteogenic differentiation of BMSCs. NcRNAs had both stimulatory and inhibitory effects on osteogenic differentiation of BMSCs. During the physiological condition, osteo-stimulatory ncRNAs are upregulated and osteo-inhibitory ncRNAs are downregulated. The opposite effects might occur during bone degenerative disease conditions. Intracellular ncRNAs and ncRNAs from neighboring cells delivered via exosomes participate in the regulatory process of osteogenic differentiation of BMSCs. In this review, we summarize the recent advances in the regulatory role of ncRNAs on osteogenic differentiation of BMSCs during physiological and pathological conditions. We also discuss the prospects of the application of modulation of ncRNAs function in BMSCs to promote bone tissue regeneration in clinics.

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Section: Mirnas Involved In the Osteogenic Differentiation Of Bmscsmentioning

confidence: 81%

The Emerging Role of Non-Coding RNAs in Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells

Chen

Xie

Zhang

et al. 2022

Front. Cell Dev. Biol.

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“…As small single-stranded non-coding RNA molecules, miRNAs have been confirmed to exert various functions such as cell growth, apoptosis, development, differentiation and inflammation, via RNA silencing and post-transcriptional regulation of gene expression ( 19 ). An increasing number of studies have confirmed that miRNAs are essential to regulate the activities of a variety of tumors.…”

Section: Discussionmentioning

confidence: 99%

hsa‑miR‑216a‑3p regulates cell proliferation in oral cancer via the Wnt3a/β‑catenin pathway

Wang

Liu

et al. 2023

Mol Med Rep

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Oral cancer is one of the leading causes of death worldwide, with a reported 5-year survival rate of ~50% after treatment. The treatment measures for oral cancer are very expensive and affordability is low. Thus, it is necessary to develop more effective therapies to treat oral cancer. A number of studies have found that miRNAs are invasive biomarkers and have therapeutic potential in a variety of cancers. The present study included 30 oral patients and 30 healthy controls. Clinicopathological characteristic and miR-216a-3p/β-catenin expression level of 30 oral cancer patients were analyzed. In addition, two oral cancer cell lines (HSC-6 and CAL-27) were used for mechanism-of-action study. The expression level of miR-216a-3p was higher in oral cancer patients compared with healthy controls and positively associated with tumor stage. Inhibition of miR-216a-3p potently suppressed cell viability and induced apoptosis of oral cancer cells. It was found that effects of miR-216a-3p on oral cancer were through Wnt3a signaling. It was also found that the expression level of β-catenin was higher in oral cancer patients compared with healthy controls and positively associated with tumor stage; the effects of miR-216a-3p on oral cancer were through β-catenin. In conclusion, miR-216a-3p and the Wnt-β-catenin signaling pathway may be interesting candidates to develop effective therapies for oral cancers.

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“…Divisato et al [36] recalled the evidence for the tumor-suppressing properties of miR-29 family members; in particular, miR-29a, involved in the early differentiation of stem cells, could mediate antiproliferative effects on melanoma cells by downregulating CDK6, a regulator of the G1/S phase. miR-29 has been already classified as a tumor-suppressor miRNA for different tumors, but now the possibility to use synthetic miR-29 as a therapeutic tool seems closer for the treatment of melanoma.…”

Section: Melanomamentioning

confidence: 99%

miRNAs, Mesenchymal Stromal Cells and Major Neoplastic and Inflammatory Skin Diseases: A Page Being Written: A Systematic Review

Vincenzo

Diotallevi

Piccirillo

et al. 2023

IJMS

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Micro RNAs (miRNAs) are a type of non-coding RNA (ncRNA) and typically interact with specific target mRNAs through complementary base pairing, affecting their translation and/or stability. MiRNAs regulate nearly all cellular functions, including the cell fate of mesenchymal stromal cells (MSCs). It is now accepted that various pathologies arise at the stem level, and, in this scenario, the role played by miRNAs in the fate of MSCs becomes of primary concern. Here we have considered the existing literature in the field of miRNAs, MSCs and skin diseases, classified as inflammatory (such as psoriasis and atopic dermatitis-AD) and neoplastic (melanoma and non-melanoma-skin-cancer including squamous cell and basal cell carcinoma) diseases. In this scoping review article, the evidence recovered indicates that this topic has attracted attention, but it is still a matter of opinion. A protocol for this review was registered in PROSPERO with the registration number “CRD42023420245”. According to the different skin disorders and to the specific cellular mechanisms considered (cancer stem cells, extracellular vesicles, inflammation), miRNAs may play a pro- or anti-inflammatory, as well as a tumor suppressive, or supporting, role, indicating a complex regulation of their function. It is evident that the mode of action of miRNAs is more than a switch on–off, and all the observed effects of their dysregulated expression must be checked in a detailed analysis of the targeted proteins. The involvement of miRNAs has been studied mainly for squamous cell carcinoma and melanoma, and much less in psoriasis and AD; different mechanisms have been considered, such as miRNAs included in extracellular vesicles derived both from MSCs or tumor cells, miRNAs involved in cancer stem cells formation, up to miRNAs as candidates to be new therapeutic tools.

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MicroRNAs and Stem-like Properties: The Complex Regulation Underlying Stemness Maintenance and Cancer Development

Cited by 10 publications

References 298 publications

The Emerging Role of Non-Coding RNAs in Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells

The Emerging Role of Non-Coding RNAs in Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells

hsa‑miR‑216a‑3p regulates cell proliferation in oral cancer via the Wnt3a/β‑catenin pathway

miRNAs, Mesenchymal Stromal Cells and Major Neoplastic and Inflammatory Skin Diseases: A Page Being Written: A Systematic Review

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