MicroRNAs and Long Noncoding RNAs in Coronary Artery Disease

Zaręba, Łukasz; Fitas, Alex; Wolska, Marta; Junger, Eva; Eyileten, Ceren; Wicik, Zofia; Rosa, Salvatore De; Siller‐Matula, Jolanta M.; Postuła, Marek

doi:10.1016/j.ccl.2020.07.005

Cited by 14 publications

(16 citation statements)

References 92 publications

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“…Currently available diagnostic methods and biomarkers are insufficient, and there is a need to seek for new, clear biomarkers that could be useful in the assessment of risk-benefit balance in antiplatelet therapy (Koupenova et al, 2017). The fact, that upon activation platelets can shed miRNAs and, what follows, affect gene expression, may suggest miRNAs as potentially useful indicators of the ongoing pathophysiological processes in the cardiovascular system (Indolfi et al, 2019;Sabatino et al, 2019;Zareba et al, 2020).…”

Section: Acs and Macementioning

confidence: 99%

“…The essence of their regulatory effects is the ability to recognize and specifically bind into the 3' untranslated region (3'UTR) of mRNAs (Jarosz-Popek et al, 2020). One miRNA can bind and regulate more than one target gene, and one single target can simultaneously be regulated by several miRNAs (Wolska et al, 2020;Zareba et al, 2020). Moreover, one single miRNA may target different mRNAs that encode proteins from the same signaling pathway, thus enriching its own regulatory capacity (Kaudewitz et al, 2016;Basak et al, 2019;Jakubik et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA as Potential Biomarkers of Platelet Function on Antiplatelet Therapy: A Review

et al. 2021

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MicroRNAs (miRNAs) are small, non-coding RNAs, able to regulate cellular functions by specific gene modifications. Platelets are the major source for circulating miRNAs, with significant regulatory potential on cardiovascular pathophysiology. MiRNAs have been shown to modify the expression of platelet proteins influencing platelet reactivity. Circulating miRNAs can be determined from plasma, serum, or whole blood, and they can be used as diagnostic and prognostic biomarkers of platelet reactivity during antiplatelet therapy as well as novel therapeutic targets in cardiovascular diseases (CVDs). Herein, we review diagnostic and prognostic value of miRNAs levels related to platelet reactivity based on human studies, presenting its interindividual variability as well as the substantial role of genetics. Furthermore, we discuss antiplatelet treatment in the context of miRNAs alterations related to pathways associated with drug response.

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Section: Acs and Macementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MicroRNA as Potential Biomarkers of Platelet Function on Antiplatelet Therapy: A Review

et al. 2021

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“…Autophagy, therefore, has a specific position in the maintenance of daily life activities [27]. Besides, while focusing on autophagy, miRNA, as the upstream of regulation, also plays a role in neurodegeneration and coronary heart disease [28,29].…”

Section: Autophagy-related Mirnas and Nonneoplastic Diseasesmentioning

confidence: 99%

The Regulating Effect of Autophagy-Related MiRNAs in Kidney, Bladder, and Prostate Cancer

Huang

Sun

et al. 2021

Journal of Oncology

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Autophagy is a treatment target for many disorders, including cancer, and its specific role is becoming increasingly well known. In tumors, researchers pay attention to microribonucleic acids (miRNAs) with regulatory effects to develop more effective therapeutic drugs for autophagy and find new therapeutic targets. Various studies have shown that autophagy-related miRNAs play an irreplaceable role in different tumors, such as miR-495, miR-30, and miR-101. These miRNAs are associated with autophagy resistance in gastric cancer, non-small cell lung cancer, and cervical cancer. In recent years, autophagy-related miRNAs have also been reported to play a role in autophagy in urinary system tumors. This article reviews the regulatory effects of autophagy-related miRNAs in kidney, bladder, and prostate cancer and provides new ideas for targeted therapy of the three major tumors of the urinary system.

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“…MicroRNAs (miRNAs, miRs) are small, endogenous RNAs that form complex signaling networks responsible for regulating cell differentiation, development and homeostasis. MiRNAs are able to regulate gene expression on the post-transcriptional level suppressing or enhancing the degradation of messenger RNA (mRNA) ( Ha and Kim, 2014 ; Eyileten et al, 2018 , 2020 ; Pordzik et al, 2018 , 2019 ; Sabatino et al, 2019 ; Gasecka et al, 2020 ; Jarosz-Popek et al, 2020 ; Soplinska et al, 2020 ; Wicik et al, 2020 ; Wolska et al, 2020 ; Zareba et al, 2020 ; Jakubik et al, 2021 ). MiRNAs take part in regulation of cell growth, cell differentiation, apoptosis, proliferation and they are thus involved in pathophysiology of cardiovascular pathology such as hypertrophy, inflammation, fibrosis and cardiomyocyte damage ( Feinberg and Moore, 2016 ; Tahamtan et al, 2018 ; Ji et al, 2019 ; Soplinska et al, 2020 ; Jakubik et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Altered Circulating MicroRNA Profiles After Endurance Training: A Cohort Study of Ultramarathon Runners

et al. 2022

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BackgroundDespite the positive effects of endurance training on the cardiovascular (CV) system, excessive exercise induces not only physiological adaptations but also adverse changes in CV system, including the heart. We aimed to evaluate the selected miRNAs expression based on bioinformatic analysis and their changes before and after an ultramarathon run.Materials and MethodsCardiac tissue-specific targets were identified with the Tissue 2.0 database. Gene-gene interaction data were retrieved from the STRING app for Cytoscape. Twenty-three endurance athletes were recruited to the study. Athletes ran to completion (100 km) or exhaustion (52–91 km, median 74 km). All participants completed pre- and post-run testing. miRNAs expressions were measured both before and after the race.ResultsEnrichment analysis of the signaling pathways associated with the genes targeted by miRNAs selected for qRT-PCR validation (miR-1-3p, miR-126, miR-223, miR-125a-5p, miR-106a-5p, and miR-15a/b). All selected miRNAs showed overlap in regulation in pathways associated with cancer, IL-2 signaling, TGF-β signaling as well as BDNF signaling pathway. Analysis of metabolites revealed significant regulation of magnesium and guanosine triphosphate across analyzed miRNA targets. MiR-1-3p, miR-125a-5p, miR-126, and miR-223 expressions were measured in 23 experienced endurance athletes, before and after an ultramarathon wherein athletes ran to completion (100 km) or exhaustion (52–91 km, median 74 km). The expressions of miR-125a-5p, miR-126, and miR-223 were significantly increased after the race (p = 0.007, p = 0.001, p = 0.014, respectively). MiR-1-3p expression post-run showed a negative correlation with the post-run levels of high-sensitivity C-reactive protein (hs-CRP) (r = −0.632, p = 0.003). Higher miR-1-3p expression was found in runners, who finished the race under 10 h compared to runners who finished over 10 h (p = 0.001). Post-run miR-125a-5p expression showed a negative correlation with the peak lactate during the run (r = −0.576, p = 0.019).ConclusionExtreme physical activity, as exemplified by an ultramarathon, is associated with changes in circulating miRNAs’ expression related to inflammation, fibrosis, and cardiac muscle function. In particular, the negative correlations between miR-125a-5p and lactate concentrations, and miR-1-3p and hs-CRP, support their role in specific exercise-induced adaptation. Further studies are essential to validate the long-term effect of these observations.

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MicroRNAs and Long Noncoding RNAs in Coronary Artery Disease

Cited by 14 publications

References 92 publications

MicroRNA as Potential Biomarkers of Platelet Function on Antiplatelet Therapy: A Review

MicroRNA as Potential Biomarkers of Platelet Function on Antiplatelet Therapy: A Review

The Regulating Effect of Autophagy-Related MiRNAs in Kidney, Bladder, and Prostate Cancer

Altered Circulating MicroRNA Profiles After Endurance Training: A Cohort Study of Ultramarathon Runners

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