Current Opinion in Hematology volume 19, issue 3, P224-231 2012 DOI: 10.1097/moh.0b013e3283523e57 View full text
Hara Kang, Akiko Hata

Abstract: Purpose of review In this review, we summarize recent advances regarding microRNA (miRNA) functions in the regulation of vascular smooth muscle cell (VSMC) differentiation and phenotypic modulation. Recent findings Multiple miRNAs are found to be responsible for VSMC differentiation and proliferation under physiological or pathological condition. A single miRNA downregulates multiple targets, whereas a single gene is regulated by multiple miRNAs to modulate a specific aspect of VSMC phenotype. Summary Th…

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