MicroRNA Profiling of Primary Cutaneous Large B-Cell Lymphomas

Koens, Lianne; Qin, Yongjun; Leung, Wai Yi; Corver, Willem E.; Jansen, Patty M.; Willemze, Rein; Vermeer, Maarten H.; Tensen, Cornelis P.

doi:10.1371/journal.pone.0082471

Cited by 23 publications

(17 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the only other study on miRs in PCLBCL-LT and PCFCL, using a different methodology based on miR profiling with high-throughput sequencing, the authors found miR-106a among the 30 miRs most abundantly expressed in 19 cutaneous B-cell lymphomas, in accordance with our results (Koens et al, 2013). When they compared PCLBCL-LT and PCFCL samples using single quantitative real-time reversetranscriptase-PCR, they found miR-9-5p, miR-31-5-p, miR129-2-3p, and miR-214-3p underexpressed in PCFCL.…”

Section: Discussionsupporting

confidence: 90%

“…In this molecular and bioinformatics study performed on skin biopsy samples from 44 patients with cutaneous B-cell lymphomas, we found an overexpression of all the miRs of the oncogenic miR-17-92 cluster in cutaneous lymphomas compared with normal skin, whereas miR-92 was overexpressed in cutaneous lymphomas compared with reactive lymph node. In the pilot study by Koens et al (2013), 3 of these miRs had also been identified in the 30 most abundantly expressed miRs in 19 PCLBCL-LT and PCFCL. Experimental data have deciphered the function of miR-17-92 cluster in lymphomas.…”

Section: Discussionmentioning

confidence: 98%

“…In cutaneous B-cell lymphomas, Koens et al (2013) performed a pilot study using miR profiling, showing a higher expression of miR-9-5p, miR-31-5p, miR-129-2-3p, and miR-214-3p in PCFCL compared with PCLBCL-LT and reporting the respective abundance of miRs in 19 patients samples. In 30 primary cutaneous marginal zone B-cell lymphoma patients, low-expression levels of miR-155 and miR-150 were associated with shorter progression-free survival (Monsalvez et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The High Expression of the microRNA 17–92 Cluster and its Paralogs, and the Downregulation of the Target Gene PTEN, Is Associated with Primary Cutaneous B-Cell Lymphoma Progression

Battistella

Romero

Castro-Vega

et al. 2015

Journal of Investigative Dermatology

View full text Add to dashboard Cite

The oncogenic microRNA (miR) 17-92 cluster has a causative role in the lymphomagenesis of nodal B-cell lymphomas, by activating proliferation and inhibiting apoptosis. Here we analyzed primary cutaneous B-cell lymphomas for the miR-17-92 cluster and its paralogs miR-106a-363 and miR-106b-25. In 22 primary cutaneous diffuse large B-cell lymphomas, leg type (PCLBCL-LT) compared with 22 primary cutaneous follicle center lymphomas (PCFCLs), we found that miR-20a and miR-106a were overexpressed. Multivariate Cox analysis showed that higher miR-20a and miR-20b expression levels were associated with shorter disease-free and overall survival, independently from histological type. Gene expression profiling also showed a downregulation of 8 candidate target genes of miR-20a, miR-20b, and miR-106a in PCLBCL-LT compared with PCFCL. Among the candidate target genes, PTEN, NCOA3, and CAPRIN2 were confirmed to be underexpressed in PCLBCL-LT using quantitative reverse transcriptase-PCR on CD20-positive laser-microdissected tumor cells. In multivariate Cox analysis, lower PTEN mRNA expression level was associated with shorter disease-free survival (DFS), independently from the histological type. Altogether, this molecular and bioinformatic study of 44 patient skin biopsy samples showed that the oncogenic miR-17-92 cluster and its paralogs were involved in cutaneous B-cell lymphoma progression, and that the downregulation of the target gene PTEN was associated with shorter DFS.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The High Expression of the microRNA 17–92 Cluster and its Paralogs, and the Downregulation of the Target Gene PTEN, Is Associated with Primary Cutaneous B-Cell Lymphoma Progression

Battistella

Romero

Castro-Vega

et al. 2015

Journal of Investigative Dermatology

View full text Add to dashboard Cite

show abstract

“…In addition, different mature forms of miR-129 display diverse expressions. Single microRNA RT-qPCR was conducted on ormalin-fixed paraffin-embedded tumor biopsies, confirming higher expression of miR-129-2-3p and in PCFCL as compared to PCLBCL-LT [27]. Yu et al reported that miR-129-1-3p, miR-129-2-3p, and miR-129-5p expression levels in gastric cancer cells were significantly 5p was significantly upregulated in the serum of acute myeloid leukemia (AML) patients compared with normal controls and underexpressed in human hematopoietic stem cells, with EIF2C3 and CAMTA1 identified as its targets, suggesting that miR-129-5p may act an important role in the genesis of AML [31].…”

Section: The Roles Of Mir-129 In Human Cancersmentioning

confidence: 83%

MicroRNA-129 in Human Cancers: from Tumorigenesis to Clinical Treatment

Gao¹,

Feng²,

Han³

et al. 2016

Cell Physiol Biochem

View full text Add to dashboard Cite

Emerging evidence has shown that microRNAs (miRNAs) play essential roles in regulating human cancers development and progression. However, the underlying mechanisms remain to be further explored. MiRNAs are a class of endogenous, non-coding, 18-24 nucleotide length single-strand RNAs that moderate gene expression primarily at post-transcriptional level. There is a growing body of literature that recognizes the importance of microRNA (miR)-129 during the development of cancers. Aberrant expression of miR-129 has been detected in various types of human cancers and the validated target genes are involved in cancer-related biological processes such as DNA methylation, cell proliferation, apoptosis, cell cycle, and metastasis. In this review, we summarized the roles of miR-129 family members and their target genes in tumorigenesis and clinical treatment of human cancers, highlighting the potential roles of miR-129 as biomarkers for cancer diagnosis and prognosis, and promising tools for cancer treatment.

show abstract

“…It is involved in the differentiation of B lymphocytes into plasma cells by the negative regulation of the transcription factor PR domain zinc finger protein 1 (PRDM1/BLIMP-1), showing lower levels as the lymphocytes differentiate. This explains high levels of miR-9-5p in primary large-B cell lymphomas [42]. On the other hand, miR-9 is downregulated in human ovarian cancer compared with normal ovary, and the overexpression of miR-9 inhibits cell growth in ovarian cancer in vitro through the negative regulation of nuclear factor NF-kappa-B p105 (NFκB1) [42,43].…”

Section: Discussionmentioning

confidence: 99%

A preliminary study of microRNA expression in different types of primary melanoma

Gencia

Baderca

Avram

et al. 2019

Bosn J of Basic Med Sci

View full text Add to dashboard Cite

MicroRNAs (miRNAs) have been proven to regulate the development and progression of cancer through various mechanisms. The aim of the present study was to compare miRNA expression between primary melanomas from different sites. We analyzed the expression of 84 miRNAs in 27 primary melanoma and 5 nevus formalin-fixed paraffin-embedded (FFPE) samples using the Human Cancer PathwayFinder miScript miRNA PCR Array. The FFPE samples were obtained from the archives of the Municipal Clinical Emergency Hospital of Timisoara and included 10 cutaneous melanomas, 10 uveal melanomas, 7 mucosal melanomas, and 5 cutaneous nevi. Out of 84 miRNAs, 11 miRNAs showed altered expression in all types of melanoma compared with the nevi. Among these, miR-155-5p, miR-9-5p, miR-142-5p, miR-19a-3p, miR-134-5p, and miR-301a-3p were upregulated, while miR-205-5p, miR-203a-3p, miR-27b-3p, miR-218-5p, and miR-23b-3p were downregulated. The highest similarity in miRNA expression pattern was found between uveal and mucosal melanoma groups, i.e., 15 miRNAs had altered expression in both groups. Overall, we identified several miRNAs with significantly altered expression in primary melanomas, including those reported for the first time in this type of cancer. Among them, mir-9-5p, mir-203a-3p, mir-19a-3p, mir-27b-3p, and mir-218-5p showed altered expression in all melanoma groups vs. nevus group. Further research should explore the potential of these miRNAs in melanoma.

show abstract

MicroRNA Profiling of Primary Cutaneous Large B-Cell Lymphomas

Cited by 23 publications

References 47 publications

The High Expression of the microRNA 17–92 Cluster and its Paralogs, and the Downregulation of the Target Gene PTEN, Is Associated with Primary Cutaneous B-Cell Lymphoma Progression

The High Expression of the microRNA 17–92 Cluster and its Paralogs, and the Downregulation of the Target Gene PTEN, Is Associated with Primary Cutaneous B-Cell Lymphoma Progression

MicroRNA-129 in Human Cancers: from Tumorigenesis to Clinical Treatment

A preliminary study of microRNA expression in different types of primary melanoma

Contact Info

Product

Resources

About