MicroRNA Expression Profile in Hyperoxia-Exposed Newborn Mice During the Development of Bronchopulmonary Dysplasia

Zhang, Xiaoying; Wei, Peng; Zhang, Sheng; Wang, Chunzhi; Xi, He; Zhang, Zhimei; Zhu, Lina; Wang, Yan; Feng, Zhichun

doi:10.4187/respcare.01032

Cited by 46 publications

(69 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the inclusion criteria and identification of duplicate publications, only three independent studies (Zhang et al, 2011;Dong et al, 2012;Bhaskaran et al, 2012) were ultimately included in the analysis. The characteristics of these studies are listed in Table 1 in the order of publication date.…”

Section: Independent Studies Includedmentioning

confidence: 99%

“…The characteristics of these studies are listed in Table 1 in the order of publication date. Zhang et al (2011) compared miRNA expression between BPD and control groups at three time points as postnatal day (P) 2, P7, and P21, which corresponds to just before, during, and after the lung septation. Furthermore, they also provided detailed accounts of miRNA expression during lung development in BPD.…”

Section: Independent Studies Includedmentioning

confidence: 99%

“…Differentially expressed miRNAs during lung development with BPD Zhang et al (2011) screened 36 specific microRNAs that showed aberrant regulation in the lung development of BPD mice only, and Dong et al (2012) showed an intersection of dynamically regulated miRNAs in normal lung alveolar development and hyperoxia-induced BPD. To ensure accuracy and comparability of these two studies, we also investigated the intersection for the miRNA sets between normal lung development and BPD lung tissues based on original data of Zhang et al (2011).…”

Section: Differentially Expressed Mirnas Between Bpd and Control Groupsmentioning

confidence: 99%

“…To ensure accuracy and comparability of these two studies, we also investigated the intersection for the miRNA sets between normal lung development and BPD lung tissues based on original data of Zhang et al (2011). Finally, based on data of these two references, we found eight miRNAs (miRNA-146b, miRNA-29a, miRNA-503, miRNA-411, miRNA-214, miRNA-130b, miRNA-382, and miRNA-181a-1*) showing differential expression not only in normal lung development, but also in the progress of BPD (Table 4).…”

Section: Differentially Expressed Mirnas Between Bpd and Control Groupsmentioning

confidence: 99%

“…Therefore, microarray-based miRNA profiling assays have attracted increasing attention because they constitute an efficient methodology for parallel screening of the expression of hundreds of miRNAs using a high-throughput probe. With the aim of identifying meaningful miRNAs of BPD, over the past several years some investigators have carried out miRNAs expression profiling studies in mammalian lung tissues (Zhang et al, 2011;Dong et al, 2012;Bhaskaran et al, 2012). As a result, dozens of differentially expressed miRNAs have been identified.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis

Yang

Qiu²,

Kan³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Over the past several years, several microRNA (miRNA) expression profiling studies have been carried out on bronchopulmonary dysplasia (BPD) in mammalian lung tissues. The most effective way to identify these important miRNAs is to systematically search for similar signatures identified in multiple independent studies. Accordingly, a meta-analysis was conducted to review published miRNA expression profiling studies that compared miRNA expression profiles between BPD lung tissues and normal lung tissues. A vote-counting strategy that considered the total number of studies and time points reporting differential expression was applied. Furthermore, cut-off criteria of statistically significant differentially expressed miRNAs as defined by the author and their predicted target genes, if available, as well as the list of up-and down-regulated miRNA features, were collected and recorded. Results of the meta-analysis revealed that four up-regulated miRNAs (miRNA-21, miRNA-34a, miRNA-431, and Let-7f) and one down-regulated miRNA (miRNA-335) were differentially expressed in BPD lung tissues compared with normal groups. In addition, eight miRNAs (miRNA-146b, miRNA-29a, miRNA-503, miRNA-411, miRNA-214, miRNA-130b, miRNA-382, and miRNA-181a-1*) were found to show differential expression not only in the process of normal lung development, but also during the progress of BPD. Finally, several meaningful target genes (such as the HPGD and NTRK genes) of common miRNAs (such as miRNA-21 and miRNA-141) were systematically predicted. These specific miRNAs may provide clues of the potential mechanisms involved in BPD. Further mechanistic and external validation studies are needed to confirm the clinical significance of these miRNAs in the development of BPD.

show abstract

Section: Independent Studies Includedmentioning

confidence: 99%

Section: Independent Studies Includedmentioning

confidence: 99%

Section: Differentially Expressed Mirnas Between Bpd and Control Groupsmentioning

confidence: 99%

Section: Differentially Expressed Mirnas Between Bpd and Control Groupsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis

Yang

Qiu²,

Kan³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

Bronchiolar Remodeling in Adult Mice Following Neonatal Exposure to Hyperoxia: Relation to Growth

O’Reilly

Hansbro

Horvat

et al. 2014

The Anatomical Record

View full text Add to dashboard Cite

Preterm infants who receive supplemental oxygen for prolonged periods are at increased risk of impaired lung function later in life. This suggests that neonatal hyperoxia induces persistent changes in small conducting airways (bronchioles). Although the effects of neonatal hyperoxia on alveolarization are well documented, little is known about its effects on developing bronchioles. We hypothesized that neonatal hyperoxia would remodel the bronchiolar walls, contributing to altered lung function in adulthood. We studied three groups of mice (C57BL/6J) to postnatal day 56 (P56; adulthood) when they either underwent lung function testing or necropsy for histological analysis of the bronchiolar wall. One group inhaled 65% O 2 from birth until P7, after which they breathed room air; this group experienced growth restriction (HE1GR group). We also used a group in which hyperoxia-induced GR was prevented by dam rotation (HE group). A control group inhaled room air from birth. At P56, the bronchiolar epithelium of HE mice contained fewer Clara cells and more ciliated cells, and the bronchiolar wall contained 25% less collagen than controls; in HE1GR mice the bronchiolar walls had 13% more collagen than controls. Male HE and HE1GR mice had significantly thicker bronchiolar epithelium than control males and altered lung function (HE males: greater dynamic compliance; HE1GR males: lower dynamic compliance). We conclude that neonatal hyperoxia remodels the bronchiolar wall and, in adult males, affects lung function, but effects are altered by concomitant growth restriction. Our findings may partly explain the reports of poor lung function in ex-preterm children and adults. Anat Rec, 297:758-769, 2014. V C 2014 Wiley Periodicals, Inc.Key words: bronchioles; epithelium; airway smooth muscle; collagen; hyperoxia; lung functionFollow-up studies of very preterm infants, especially those who developed bronchopulmonary dysplasia (BPD) in infancy, show that the risk of impaired lung function in later life is increased (Doyle et al., 2006;Kulasekaran et al., 2007); the incidence of childhood asthma (Fawke et al., 2010) and reduced exercise capacity are also increased (Smith et al., 2008). Such findings suggest that very preterm birth, or factors associated with it, may permanently affect the conducting airways of the lung.

show abstract

Postnatal inflammation in the pathogenesis of bronchopulmonary dysplasia

Bhandari

2014

Birth Defects Research

View full text Add to dashboard Cite

Exposure to hyperoxia, invasive mechanical ventilation and systemic/local sepsis are important antecedents of postnatal inflammation in the pathogenesis of bronchopulmonary dysplasia (BPD). This review will summarize information obtained from animal (baboon, lamb/sheep, rat and mouse) models that pertain to the specific inflammatory agents and signaling molecules that predispose a premature infant to BPD.

show abstract

MicroRNA Expression Profile in Hyperoxia-Exposed Newborn Mice During the Development of Bronchopulmonary Dysplasia

Cited by 46 publications

References 21 publications

MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis

MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis

Bronchiolar Remodeling in Adult Mice Following Neonatal Exposure to Hyperoxia: Relation to Growth

Postnatal inflammation in the pathogenesis of bronchopulmonary dysplasia

Contact Info

Product

Resources

About