MicroRNA Expression in Colon Adenocarcinoma

The microRNA-processing enzymes: Drosha and Dicer can predict prognosis of nasopharyngeal carcinoma

“…Large-scale proWling has revealed a global alteration of miRNA expression patterns in human cancers (Murakami et al 2006;Kida and Han 2008), especially in NPC (Chen et al 2009). Biological characterisation has also identiWed several miRNAs that function as tumour suppressors or oncogenes.…”

A microRNA expression signature as a predictor of survival for colon adenocarcinoma

“…Expression signatures of miRNas have been proposed to be effective biomarkers for detection, intervention and prognosis of cancers [12,13]. The prognostic role of miRNas´ expressions in colon cancer has been reported [14][15][16][17]. For example, higher expression of miR-29a in stage II colon cancer was associated with a longer disease-free survival of the patients [17,18], and higher miR-21 expression in colon adenocarcinoma was associated with low survival rate and resistance to chemotherapy [15].…”

MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma

“…Biological characterisation also identified several miRNAs function as tumour suppressors or oncogenes (Chen, 2005;Croce, 2008). Large scale profiling revealed a global alteration of miRNA expression patterns in human cancers (Lu et al, 2005;Murakami et al, 2006;Kida and Han, 2008). Recently, distinct miRNA expression signatures have been proposed as diagnostic and prognostic markers for various types of human cancer (Yanaihara et al, 2006;Schetter et al, 2008;Yu et al, 2008).…”