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Cited by 10 publications
(10 citation statements)
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References 9 publications
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“…Loss of CSF-1R Tyr-721 was associated with loss of CSF-1 induction of miR-21 ( Figure 4; supplemental Figure 4), which could be due to inefficient processing of miR-21 from its precursor forms, [78][79][80] decreased stability of mature miR-21, 81 or other processes. 82 To investigate the regulation of M1/M2 functions by miR-21, the predicted mRNA targets were validated and shown to predominantly encode molecules promoting an M1 phenotype (Figure 4; supplemental Tables 6-8).…”
Section: Discussionmentioning
confidence: 99%
“…Loss of CSF-1R Tyr-721 was associated with loss of CSF-1 induction of miR-21 ( Figure 4; supplemental Figure 4), which could be due to inefficient processing of miR-21 from its precursor forms, [78][79][80] decreased stability of mature miR-21, 81 or other processes. 82 To investigate the regulation of M1/M2 functions by miR-21, the predicted mRNA targets were validated and shown to predominantly encode molecules promoting an M1 phenotype (Figure 4; supplemental Tables 6-8).…”
Section: Discussionmentioning
confidence: 99%
“…While depletion of DGCR8, and DICER1 induces spontaneous senescence (Gómez‐Cabello, Adrados & Palmero, 2013; Mudhasani et al., 2008), AGO2 depletion itself did not promote cellular senescence but sensitized it to RAS‐oncogene‐induced cellular senescence (Yang et al., 2014). These findings suggest that AGO2 mRNA demethylation and subsequent decrease in AGO2 level are not sufficient but could be required for cellular senescence by METTL3 or METTL14 depletion (Figure 8b).…”
Section: Discussionmentioning
confidence: 99%
“…These age-associated epigenetic modifications could underlie some of the transcriptional signatures associated with aging, such as the dysregulation of gero-miRNAs [ 140 ], a miRNA class which has been shown to affect longevity in Caenorhabditis elegans [ 141 ] and Drosophila melanogaster [ 142 ] as well as modulating stem cell behaviour in mammals. Interestingly, miRNAs regulate a wide variety of DNA damage response components (reviewed in Ugalde et al [ 135 ]), and have been shown to play roles in other processes that affect regenerative capacity during aging such as cell metabolism and cellular senescence [ 143 ]. Furthermore, miRNA regulation is important for regeneration in species that do not exhibit an age-associated decline in this process such zebrafish [ 144 , 145 ] and salamanders [ 146 , 147 ].…”
Section: Factors That Affect Regenerative Capacity During Agingmentioning
confidence: 99%