2012
DOI: 10.1371/journal.pone.0042034
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Abstract: BackgroundMDM4, also called MDMX or HDMX in humans, is an important negative regulator of the p53 tumor suppressor. MDM4 is overexpressed in about 17% of all cancers and more frequently in some types, such as colon cancer or retinoblastoma. MDM4 is known to be post-translationally regulated by MDM2-mediated ubiquitination to decrease its protein levels in response to genotoxic stress, resulting in accumulation and activation of p53. At the transcriptional level, MDM4 gene regulation has been less clearly under… Show more

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Cited by 81 publications
(71 citation statements)
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“…For example, miR-602 and miR-608 were reported to target Sonic Hedgehog (SHH) mRNA transcripts within its coding domain sequence [34], while miR-34a showed similar regulatory roles for MDM4 expression [35]. However, in contrast to the well-established roles of miRNAs binding the 3′-UTRs of mRNA transcripts, the regulatory mechanism of miRNAs targeting mRNA coding domain sequences remains to be clarified.…”
Section: Discussionmentioning
confidence: 99%
“…For example, miR-602 and miR-608 were reported to target Sonic Hedgehog (SHH) mRNA transcripts within its coding domain sequence [34], while miR-34a showed similar regulatory roles for MDM4 expression [35]. However, in contrast to the well-established roles of miRNAs binding the 3′-UTRs of mRNA transcripts, the regulatory mechanism of miRNAs targeting mRNA coding domain sequences remains to be clarified.…”
Section: Discussionmentioning
confidence: 99%
“…3D; Supplemental Fig. S2H) and its important functions as one major negative regulator of p53 (Marine et al 2006;Markey and Berberich 2008;Mandke et al 2012;Wade et al 2013). mdm4/HDM4 and its closely related homolog, mdm2/HDM2, both encode RING domain proteins that promote oncogenesis by inhibiting p53 (Marine et al 2006;Wade et al 2013).…”
Section: Cold Springmentioning
confidence: 99%
“…MicroRNAs (miRNAs) are a class of small, single-stranded non-coding RNAs (~22 nucleotides) that are transcribed from the DNA of a gene, and modulate the expression of a network of mRNAs through binding to the 3'-untranslated region (3'-UTR), 5'-UTR or to the open reading frame of target mRNAs (15). Notably, each miRNA is able to target multiple mRNAs.…”
Section: Introductionmentioning
confidence: 99%