2011
DOI: 10.1038/onc.2011.340
| View full text |Cite
|
Sign up to set email alerts
|

Abstract: Aberrant expression of miR-335 has been frequently reported in cancer studies, suggesting that there is a close correlation between miR-335 and cancer during its development, progression, metastasis and prognosis. The expression of miR-335 in gastric cancer and its effects are not known. Relative expression of miR-335 in 4 gastric cancer cell lines and in 70 gastric cancer tissues was confirmed by real-time quantitative reverse transcriptase-PCR compared with controls. Transwell cell migration and Matrigel inv… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

5
127
0

Year Published

2014
2014
2023
2023

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 166 publications
(132 citation statements)
references
References 46 publications
5
127
0
Order By: Relevance
“…miR-335 serves as a tumor suppressor miRNA, is transcribed from the genomic region on chromosome 7q32.2 (76) and is downregulated in various human digestive malignancies, such as pancreatic carcinoma, hepatocellular carcinoma, colorectal cancer and gastric cancer (77)(78)(79)(80). A similar result was also observed in GBC patients.…”
Section: Tumor Suppressor Micrornassupporting
confidence: 67%
“…miR-335 serves as a tumor suppressor miRNA, is transcribed from the genomic region on chromosome 7q32.2 (76) and is downregulated in various human digestive malignancies, such as pancreatic carcinoma, hepatocellular carcinoma, colorectal cancer and gastric cancer (77)(78)(79)(80). A similar result was also observed in GBC patients.…”
Section: Tumor Suppressor Micrornassupporting
confidence: 67%
“…miR-29b and miR-375 function as tumor suppressors in TSCC through targeting SP1 (39,40). miR-145, miR-133a, miR-133b, miR-22 and miR-335 serve an important role in the biology of gastric cancer by regulating SP1 directly (41)(42)(43). miR-145 was also found to regulate SP1 in ovarian cancer cells sensitized to paclitaxel (44).…”
Section: Discussionmentioning
confidence: 87%
“…For example, the overexpression of miR-335 was observed to suppress breast cancer cell proliferation, cell cycle progress, colony formation and cell invasion through the negative regulation of Paired box 6 (30). Xu et al (31) reported that the expression level of miR-335 was relatively low in gastric cancer tissues, and that a low miR-335 expression level was correlated with lymph node metastasis, an advanced pT and pN stage, and the invasion of lymphatic vessels. The upregulation of miR-335 may have inhibited gastric cancer cell invasion and metastasis in vitro and in vivo by directly targeting SP1, as well as acting indirectly through the Bcl-W-induced phosphoinositide 3-kinase-Akt-SP1 pathway (31).…”
Section: Discussionmentioning
confidence: 99%
“…Xu et al (31) reported that the expression level of miR-335 was relatively low in gastric cancer tissues, and that a low miR-335 expression level was correlated with lymph node metastasis, an advanced pT and pN stage, and the invasion of lymphatic vessels. The upregulation of miR-335 may have inhibited gastric cancer cell invasion and metastasis in vitro and in vivo by directly targeting SP1, as well as acting indirectly through the Bcl-W-induced phosphoinositide 3-kinase-Akt-SP1 pathway (31). The reduced expression of miR-335 was also identified in human prostate cancer tissues and cell lines; miR-335 expression level was associated with a high Gleason Score, advanced clinical stage and metastasis in patients with prostate cancer (32).…”
Section: Discussionmentioning
confidence: 99%